Both laser diffraction (LD) and differential centrifugal sedimentation (DCS) are used for quantitative particle size distribution analysis of samples in the sub-micron region. LD can be described as a low-resolution, wide-dynamic-range technique that is robust, fast and easy to operate. DCS is a high-resolution particle-sizing technique, and is now similarly robust, fast and simple to use. Historically, however, DCS has been limited in dynamic range; but with the introduction of speed ramping, the dynamic range capabilities of DCS are now much improved.

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