Skip to main content
Read more on IOPscience

What’s the difference between a left-handed molecule and a right-handed one?

02 Jul 2025 Paul Mabey

A team led by researchers from the Norwegian University of Science and Technology have found a new method to separate right- and left-handed molecules using circularly polarised light

enantiomers
A new optical technique can distinguish between right- and left-handed (rectus and sinister in Latin) molecules. (Courtesy: iStock/DariaRen)

Most complex carbon molecules – such as those necessary for life – actually exist in two forms. The normal one and its mirror image. The left-handed version and the right-handed version.

Despite containing the same atoms, these two molecules usually have vastly different properties. For example, one might be used as a therapeutic drug, while the other could be inactive or even harmful.

Separating them is therefore very important for several reasons, particularly in the fields of chemistry, biology, and medicine. However, due to the lack of differences in the physical properties of the two molecules, this is usually quite difficult.

When any molecule is exposed to light, its quantum energy levels are split apart because of the interaction.

In this paper, the team found that when this light is circularly polarised, the splitting is different for the two mirrored molecules. They also went on to find that this effect led to different photochemical reactions for each molecule, further providing ways to distinguish them.

These effects could then be used as new methods for separating these mirrored molecules in medicine and beyond.

Read the full article

Chiral polaritonics: cavity-mediated enantioselective excitation condensation – IOPscience

R. Riso et al. 2025 Rep. Prog. Phys. 88 027901

 

Copyright © 2025 by IOP Publishing Ltd and individual contributors