Biological function relies on co-ordinated cell behaviour, driven by molecular processes involving DNA in the cell nucleus. The 3D genome refers to the hierarchical and organized packing of the meter-long DNA into the nucleus. The 1D genome refers to the functional roles of DNA regions and epigenetic modifications (like methylation) that form a non-equilibrium, dynamic code. The goal of the workshop is to present the mechanisms by which 1D and 3D processes are integrated together, and the consequent emergence of complex spatio-temporal structures in the tight nuclear environment.