Physics teaching: subject specialists can bridge the attainment gap
Physics graduates, it seems, remain resolutely unconvinced by the prospects of life in the classroom. The numbers don’t lie. Official data from the Department for Education (DfE) in England show that there were 41,472 new entrants to postgraduate initial teacher-training (ITT) courses in the academic year 2019/20 – an uptick on the postgraduate trainees in 2019/20. Yet while subjects like biology, history and geography exceeded recruitment targets specified in the so-called Teacher Supply Model (TSM) – a government forecast of the number of postgraduate ITT entrants needed to provide sustainable numbers of qualified teachers – it’s notable that recruitment performance against TSM targets was well off in other subjects such as physics (bottom of the pile at just 45%).
Drill down into the data and the situation is most acute for schools serving areas of socioeconomic disadvantage with a history of academic underachievement. “More than one in ten teachers from the most disadvantaged secondary schools leave to teach in other schools – about twice the proportion who make the same move from the least disadvantaged schools,” notes the DfE’s Teacher Recruitment and Retention Strategy (2019). Those higher levels of turnover, argues the DfE, only serve to amplify the problems of attracting subject specialists – not least physicists – to schools within low-income communities.
It’s all about outcomes
Ark Teacher Training is seeking to redress that imbalance with a proactive recruitment strategy to attract more physics graduates into the teaching profession. That’s particularly significant because the specialist training provider is an offshoot of Ark, an international education charity with a network of 38 schools across England – each of those schools serving an economically disadvantaged catchment in Birmingham, Hastings, London or Portsmouth.
“The national shortage of physics teachers is deeply unfair – and especially so in schools serving the most disadvantaged children,” explains Isabel Instone, senior tutor and head of curriculum and assessment at Ark Teacher Training. “We’re targeting physics graduates, in particular, to come and train with Ark because we believe every child deserves to be taught by a subject expert.”
Put simply, says Instone, physicists are best placed to paint the “bigger picture” on their subject, highlighting connections between science and the real world that will inspire children to pursue further study, and ultimately careers, in science and engineering. “With Ark,” she adds, “physics graduates will be part of a network of teachers and schools focused squarely on bridging the attainment gap and delivering better educational outcomes for disadvantaged children.”
Teaching the teachers
One physicist who’s experienced the Ark Teacher Training programme first hand is Phil Entwhistle at Ark Elvin Academy, a secondary school for students aged 11–16 in Brent, North London. After completing a physics degree at the University of Exeter in 2014, Entwhistle spent a gap year in the Canadian Rockies (think snowboarding and mountain-biking) before a two-year stint working for the British Red Cross.

“You’re in the classroom from day one,” explains Entwhistle. “For me, that’s one of the big selling points of Ark – the training is research-based but very much practice-centric. At the same time, there’s a fantastic level of support from your professional development tutor, your coach [an experienced teacher] and your peer network of fellow trainees.”
That support kicks in upfront with a two-week summer school that brings all new trainees together for an introduction to the Ark programme and the principles of great teaching. “The summer school is all about orientation,” notes Entwhistle. “The main focus is on what we call ‘climate for learning’ – how to manage behaviour in a classroom and practising what to do in various scenarios. The key to getting good quickly as a teacher is having control of the room.”
Continuous improvement
Once formal training gets under way, student teachers from different schools in the Ark network get together for weekly training sessions led by a specialist tutor. The tutor’s role is to support and develop teaching best practice, though the peer interaction and sharing of collective experience are equally important – whether that’s on matters of general pedagogy, how to plan a great lesson, or the strategies and language needed to teach difficult subjects and concepts.
In the classroom, meanwhile, each trainee is assigned a coach, an experienced teacher who they will work with and learn from on a daily basis. From the outset, trainees will teach some classes independently, while others involve “team-teaching” with their coach – managing a small chunk of the lessons and observing the rest of the time. “Seeing what experienced teachers do and how they do it has tremendous value,” says Entwhistle. However, that dynamic shifts, and ultimately flips, as the training year progresses, with trainees assuming the lead role on teaching duties and the coach acting more in an observer/adviser capacity.
To a large degree, the coach’s role is to fast-track continuous improvement of the trainee’s classroom practice. “The coach will observe at least one of your lessons each week and highlight an aspect of your approach that will have the biggest impact if you develop it,” explains Entwhistle. “That bite-sized action step then becomes your main focus for the following week. Incremental changes, week by week, that add up to something much more over time.”
After successful completion of the Ark Teacher Training programme, which comes with qualified teacher status (QTS) and a postgraduate certificate in education (PGCE), Entwhistle took up a newly qualified teacher (NQT) post in science at Ark Elvin Academy. After the NQT year, and becoming a fully qualified teacher, he progressed to lead physics teachers, a role that involves oversight and development of the school’s physics curriculum as well as coaching Ark trainee teachers.
- To find out more, register for the Ark Teacher Training webinars here.
Reimagining best practice in the classroom
Ark Teacher Training launched in 2013, an offshoot of parent group Ark’s established network of schools across England. Since then, the organization has seen over 550 graduates complete its teacher training programme, all of them earning qualified teacher status (QTS) and a postgraduate certificate in education (PGCE) accredited by Goldsmiths, University of London. A further 150 student teachers in the 2019/20 cohort are working towards QTS later this year. Isabel Instone, senior tutor and head of curriculum and assessment at Ark Teacher Training, talked to Physics World about the guiding principles of Ark’s training model.

What does your role at Ark Teacher Training involve?
Assessment and moderation are a big part of what I do. I’m responsible for designing procedures to check how well our trainees are progressing through the training year – and, if necessary, to support any students who might be struggling. The curriculum aspect is more geeky – so looking at what and how we teach our trainees, also ways we can improve the training. One aspect of that is to work with specialist subject leads to come up with innovative ways to teach difficult-to-grasp subjects – for example, electricity and energy – without introducing common misconceptions.
What differentiates Ark versus other teacher-training providers?
We have a consistency of approach – the language we use, our training methods – to provide the best possible support to teachers during their training year and the early years of their career. It’s in these formative stages when teachers make the most significant improvements to their daily practice. We talk a lot about the “get it, do it” gap for trainees. It’s not enough to get the theory or to see what great teaching practice looks like. You have to be able to deliver in the classroom.
How do you help trainees to raise the bar in terms of best practice?
We use videos to inform almost every training session – more often than not using lessons filmed in our schools and delivered by former trainee teachers within the Ark programme. It’s a fantastic exercise to deconstruct at a granular level what makes a lesson good – and the steps needed to plan and deliver that lesson. Using those insights, our trainees will practice their own lesson in front of their peers, getting group feedback along the way, so that they can implement in the classroom the next day. It’s too important to practise new teaching strategies for the first time in front of the children.
How do you ensure the programme continues to develop?
We have a continuous improvement mindset at Ark and take a lot of cues from trainees, mentors and senior leaders within our schools. Several recent changes are linked to trainee wellbeing and workplace – for example, getting into good habits early on when it comes to work/life balance.
Why should prospective candidates choose Ark?
The programme ensures there’s no gap between what is taught – the theory – and what the trainees do in the classroom. Our aim is to make them as effective as possible as quickly as possible. Longer term, we want our trainee teachers to build a career in the Ark network and ultimately move into leadership positions in our schools. We support trainees who successfully complete their training year [and earn their QTS/PGCE] to secure an NQT role in their current school or another school in the Ark network.
Nanowire device generates electricity from ambient humidity
Scientists in the US claim to have developed a device that can generate electricity from moisture in the air. The device, based around a thin film of electrically conductive protein nanowires, can produce continuous electrical power for around 20 h, before self-recharging. The researchers say that such technology could provide clean energy without the restrictions on location and environmental conditions of other renewable energy solutions such as solar cells (Nature 10.1038/s41586-020-2010-9).
The device consists of a roughly 7 µm thin film of protein nanowires, harvested from the microorganism Geobacter sulfurreducens, deposited on a gold electrode with an area of around 25 mm2. A smaller, roughly 1 mm2, electrode is placed on top of the nanowire film.
Jun Yao, an electrical engineer at the University of Massachusetts, and his colleagues found that this set-up was able to produce a continuous current for more than 20 h. After 20 h, the voltage had dropped from around 0.5 V to 0.35 V, but when the load was removed, it went back up to 0.5 V within five hours, showing a self-recharging process.
The researchers also connected multiple devices together to increase the output. With 17 devices they were able to generate 10 V, and demonstrated that these connected devices could power an LED or a small liquid crystal display.
G. sulfurreducens was discovered by Derek Lovley, a microbiologist at the University of Massachusetts. He tells Physics World that the bacteria use the electrically conductive nanowires to make connections with other microbial species and with minerals. “For example, in soils and sediments, Geobacter feeds electrons to methane-producing microorganisms, which use the electrons to convert carbon dioxide to methane,” Lovley says. “Geobacter also electrically connects to iron minerals in soils and sediments to use iron minerals similarly to how we use oxygen.”
Electricity from thin air
Energy is generated in the device due to a moisture gradient that forms within the nanowire film when it is exposed to the humidity naturally present in air, according to the researchers. The smaller electrode on the top is key, as it leaves one side exposed to the humid air, allowing the moisture gradient to develop.
Yao tells Physics World that the way the device works can be compared with lightning. “The cloud builds up positive and negative charges at the upper and lower sides, and upon a certain threshold, it discharges through the lightening,” he explains. “This indicates that charge can be built up from the ambient environment and we may be able to harvest it for electricity production. One can think of our device to be a small cloud, with one side open to air and the other sealed. Water molecules in the air constantly bump into the open surface, creating more charges than on the other one. The charge difference eventually will build up electric field or potential difference, which will drive the electric current output.”
Falling water drops power LEDs
The team experimentally determined that ambient humidity was the source of energy by sealing the top of the device, to block water-molecule exchange with the nanowires. This cut the electrical output, which returned once the seal was removed. They also found that increasing the ambient humidity, and thus the water-molecule exchange rate, increased the electric output. To check that there were no electrochemical reactions with the gold plates, the team replaced them with inert carbon electrodes, and were able to generate similar voltages. The device also worked in the dark, eliminating a photovoltaic effect.
Yao says that the researchers are now working on connecting devices together to increase the power volume. “We have demonstrated that the devices can be connected to increase the power, so at a certain point, it is proven this will scale,” he says. “We are working on material sciences and engineering strategies to scale up the technology.”
Turning water into watts
In many ways, the ocean seems like the most obvious place in the world to look for energy.
Water covers about 70% of the planet, and much of it, driven by the Sun, is in constant motion. Surface swells ferry energy from one place to another, while tides and currents, as reliable as the sunrise, move vast volumes of water in very short times. The ocean is essentially a natural engine, converting solar energy into mechanical energy. Hardly surprising, then, that for at least 200 years, visionaries have dreamt of harnessing that constant, reliable motion and using it to power the world.
Numerous proposals have been made in this quest for “blue energy”, ranging from the practical to the outlandish. Perhaps the first known patent was filed in 1799 by a French family who wanted to use a lever – with one end bouncing on ocean waves – to power their sawmill and other machines. Since then, from the straits off northern Scotland to the wind-swept shelf waters near Victoria and Tasmania in Australia, scientists have been searching for the ocean’s “sweet spots”, where energy harvesting is feasible, reliable and cheap.
Harbours, tidal rivers and coastlines around the world have become testbeds for systems that can generate power, plug into the grid and survive the harsh conditions of the sea. Indeed, a study published in Science in May 2019 (364 548) further sweetens the pot. After analysing data from satellites and a global network of floating buoys, ocean engineer Ian Young and mathematician Agustinus Ribal, both from the University of Melbourne in Australia, found that the ocean’s tallest waves are getting taller and that ocean wind speeds are increasing – likely because of climate change. They could therefore have more energy to share.
But at least two variables threaten to submerge these efforts. The first is money. Between 2013 and 2015, at least three big companies with plans to connect wave-power generators to the electricity grid all lost funding and abandoned their projects. One of them, Pelamis, had tested facilities around the world. Another, Aquamarine, based in northern Scotland, had spent 10 years developing a floating-buoy wave-generator system, called the Oyster, but failed to bring in investors. A third, Oceanlinx, began in Australia in 1997 and was sold to a Hong Kong company in 2014.
The sea is an unforgiving environment. It is corrosive, fouling, energetic and forceful
The other big hurdle is the power of the sea itself. In the winter of 1988, for example, a fierce storm in Toftestallen, Norway, slammed a wave-power plant that had been installed barely three years earlier. The unhinged tower collapsed and the station had to be rebuilt, only to be destroyed again by accident during an attempted improvement three years later. In 2009, meanwhile, a dozen underwater turbine blades were wrecked by strong tides in the Bay of Fundy, Canada, less than a month after they had been plumbed in. And in November 2007 a brand new power-generating test buoy that had cost $2m to install took on too much water and sank in the Pacific waters off the coast of Oregon.
“The sea is an unforgiving environment,” admits Elaine Buck, a technical manager at the European Marine Energy Centre (EMEC), an open-sea testing facility based in Stromness, Orkney, Scotland, that studies wave- and tidal-power generators. “It is corrosive, fouling, energetic and forceful. Marine energy is harnessed at the extreme environmental edges.” Hardly surprising, then, that ocean power has made far fewer inroads than other sustainable-energy sources, such as solar and wind.
Ups and downs
There are, though, signs of progress. To see one in action, you can go to Gibraltar, the British territory that juts out from Spain into the Mediterranean Sea. On the east side of The Rock, on a jetty used during the Second World War to transport ammunition, lie eight blue mechanical arms attached to wide buoys that rise and fall as waves roll in from the sea. When waves reach a height of 0.5 m, the device’s oscillating arms drive pistons that pump hydraulic fluid into an onshore power station. There, the fluid spins a hydro motor, generating electricity that flows into Gibraltar’s grid.
Installed in 2016 by Eco Wave Power – a Swedish firm based in Tel Aviv, Israel – the wave station currently has a capacity of 100 kW of electricity. That should be enough to power a few dozen homes and makes Gibraltar one of the few places in the world where ocean waves supply the electrical grid. Eco Wave Power now intends to scale up the technology by installing more units to provide 5 MW of electricity, which would represent 10–15% of the territory’s demands. The firm is also planning future projects where wave power has potential, including in Portugal, Italy, the Netherlands, Australia, Mexico and the UK. The sum total of all these proposed projects would be 190 MW, says Eco Wave Power’s chief executive, Inna Braverman.

Another firm in the blue-energy game is the Finnish company AW-Energy, which last year installed a device called a WaveRoller on an off-shore platform near Peniche, a seaside village in Portugal. It’s a rectangular panel that, unlike the machine in Gibraltar, is anchored to the seabed and oscillates back and forth as waves pass. That action sends hydraulic fluid through a set of sealed pipes, driving a hydraulic motor that generates electricity. The company is currently collecting off-grid test data on the machine.
Perhaps the longest-running blue-energy project is in the Bay of Biscay, off the coast of northern Spain. Completed in 2011, it consists of a set of 16 columns drilled into a 440 m-long artificial breakwater that juts into the sea from the town of Mutriku. Ocean waves push air through the columns, with the resulting high air pressure spinning turbines. Developed by the Scottish firm Wavegen, the facility is owned by the Spanish utility company Ente Vasco de la Energia. It has so far supplied 1.6 GWh of electricity to the local grid – roughly the same as you’d get from burning 650 tonnes of coal.
Despite these inroads, however, wave energy isn’t remotely close to a tipping point where it’s both commercially appealing and sustainable on large scales. “Wave energy development has yet to move past prototype-scale projects, funded by government grants, private investors, and venture capital,” concluded an analysis published by Bloomberg Finance in September 2019.
Too big to fail
According to the US Energy Information Administration, the world will use more than 21,000 TWh of electricity overall in 2020, with roughly three-quarters of that consumption coming from China and the US. Global usage is estimated to rise by 50% over the next 30 years. However, more than four-fifths of the world’s energy currently comes from burning non-renewable fossil fuels such as coal and oil, which release gases into the atmosphere and affect climate change.
Turning to the seas for an energy seems a no-brainer. The ocean is an energy-rich environment, which makes it an appealing alternative to fossil fuels. The Sun heats the land and air, and – as warm air rises and cool air rushes in beneath – winds blow and push the water. Waves rise and race as gravity works to restore equilibrium. The rate at which waves deliver energy (the energy flux) depends on how fast the waves are moving and on the “significant wave height” – a variable that oceanographers use to characterize how high the highest waves tower over sea level. (The energy flux also depends on the density of the water, though that’s treated as a constant for ocean waves.)
The power delivered by tides depends on the volume and speed of water passing a particular point. According to the US Ocean Energy Council, an average coast-pummelling wave towering 1.5 m over the sea’s surface delivers about 16 kW per kilometre of coastline. Meanwhile, a 2017 analysis by the International Energy Agency reckons that the amount of energy stored in waves, worldwide, is about 80,000 TWh, of which about 4000 TWh could be harvested and converted into electricity. More conservative estimates, such as those from the UK-based Carbon Trust, suggest a harvestable range of 2000–4000 TWh.
Ocean currents – rather than waves or tides – are similarly appealing. In 2017 Tsumoru Shintake – an engineer at the Okinawa Institute of Science and Technology Graduate University in Japan – claimed that if energy harvesters could harness the current moving along just 1% of the Japanese seashore, you’d generate more power than from 10 nuclear plants. Scientists at the Coastal Studies Research Institute in North Carolina calculated that capturing just 0.1% of the power in the Gulf Stream, which runs along the east coast of the US, would yield 300 GW – equivalent to more than 150 nuclear plants.
In light of the fact that half of the world population lives within 80 km of a coast, these figures suggest the ocean could, in the future, provide up to 10% of the world’s energy demands. That doesn’t include the energy gained from harnessing tides, which some researchers say has the potential to be even more efficient – and stable – than wave-energy products. So if scientists can find the right approach, then the entire energy demand of the world – or a significant part of it, anyway – could be met by the ocean. But that’s a colossal if.
Sunken dreams
Perhaps the most ambitious blue-energy project – the likes of which the world has never seen – was the brainchild of a German engineer named Herman Sörgel (1885–1952). Dubbed Atlantropa, he described it in a 1929 book and spent his life trying to convince others to get on board. Essentially, Sörgel wanted to build hydroelectric dams around the Mediterranean Sea, including a huge one across the Strait of Gibraltar, which would lower the sea level and connect Europe to Africa through new, usable land masses. A dam across the Congo River, meanwhile, would irrigate the Sahara Desert and produce fertile new plains.
Sörgel’s attempt to harness the ocean never saw the light of day. Nor did many others, despite appearing feasible, at least on paper. Take the Bay of Fundy, which lies between the islands of New Brunswick and Nova Scotia in Canada. Apart from being home to a dizzying variety of whale species, the bay boasts the world’s highest tides, which can reach more than 15 m in height. That fact led one enterprising engineer from Boston to persuade the US government in the 1930s to give him $7m to build machines to harvest the bay’s tidal energy. A plant was built and a small town grew around it, but in 1936 funding ran out and the project was declared too expensive. The town evaporated.
Since then, a steady stream of proposals have washed in and out, like the tides themselves. In 2009, for example, a collaboration between Scottish and Canadian companies built an underwater turbine in the Bay of Fundy, but it was destroyed by powerful tides less than a month after installation. Between November 2016 and April 2017, the same collaborators – working under the name Cape Sharp Tidal – tried again, this time with a grid-connected turbine in the bay’s Minas Passage. But with the firm plagued by technological and financial problems, last April the government of Nova Scotia ordered the turbine to be removed. Undeterred, another firm – Jupiter Hydro from Alberta – has recently obtained two permits to test new turbines in the water.
Beneath the waves
Back at EMEC in Orkney, Buck says many projects have come and gone since the centre was set up in 2003. Indeed, experience has taught her not to try to predict what unknown challenges lay in the future, with Buck joking that “it’s about as realistic as determining the outcomes of Brexit”. In the last two years, for example, EMEC has hosted a grid-connected, floating tidal-power generator, built by a Scottish company called Orbital, that generated 3 kWh in 2018. An upgraded version of the same device has a planned installation for later this year. There have also been some unexpected failures, like an inflatable, floating wave-power harvester that sank to the seabed in March 2019. (It will be recovered later this year.)
Buck says, however, that she’s not daunted by the fact that many projects don’t pan out. “There are successes and failures,” she says, “but learning is in the failures.” And the more projects they test, she says, the shorter the learning curve for future developers with big ideas.
Ultimately, Buck says, she sees the most promise in those devices that can harness the tides as opposed to those powered by waves. “Technological challenges for wave power still remain,” she says, but “tidal [devices] are on pace to deliver grid-scale power.”
Most approaches to harvesting mechanical energy from ocean waves rely on finding a way to move a conducting wire through a magnetic field to generate electricity. It seems the obvious way of going about things, given that electromagnetic generation is the cornerstone of the entire power-generation industry. From fossil-fuel plants to wind turbines, the basic conversion from mechanical energy to electricity is the same.

But ocean harvesters don’t have to work that way, argues Zhong Lin Wang, an engineer at the Georgia Institute of Technology, in Atlanta. Over the last few years, he has been building triboelectric nanogenerators, or TENGs, which he says could revolutionize energy harvesting. Instead of generating power using moving conductors and magnets, Wang’s TENGs generate a trickle of current using static electricity. In these devices, two materials rub against each other – one donating charges, the other collecting them – and the accumulated charges flow through an attached wire. Wang has used TENGs to design, among other things, keyboards that harvest energy from typing, and table-tennis tables that can record a ball’s trajectory and speed, powered by the bounce of the ball itself.
“These could become a very important energy source,” he says. Wang has, for example, designed TENGs in small plastic spheres, about the size of oranges, that float in water. As the waves jostle the sphere, material inside bumps against the outer shell, generating charges. Those charges then flow through an attached wire. In lab tests – and in night-time experiments conducted at his neighbourhood pool – each one can generate about 10 mW of power.
That’s not much, Wang admits, but he thinks it could be used at first for powering small devices – think sensors on buoys used to collect data on the sea. Moreover, he thinks the technology will scale up. “Imagine we make a network, like a fishing net,” says Wang, who envisages a grid of spheres, each about 10 cm apart, and extending 10 m down into the water. Such a configuration, but scaled up to the size of the state of Georgia (about 400 km wide and long), could power the whole world, he believes.
Wang’s approach offers appealing advantages. Basic physics says that the energy carried by a wave is proportional to the square of its height, as well as the square of the angular frequency. Electromagnetic generators – like those used in most wave-harvesting devices – therefore work best at high frequencies. But Wang’s TENGs follow the rules of electrostatic generators, which means that their output scales linearly with frequency. So while conventional wave harvesters have an advantage for giant swells, TENGs can function even with small vibrations. Rivers, which typically don’t have a strong enough current for wave harvesters, might therefore be good testing grounds for TENGs.

TENGs could also have an advantage in big storms, which pose problems for conventional wave-harvesting. Eco Wave Power’s device in Gibraltar, for example, has to raise its mechanical arms out of the water when big tempests roll in. But a TENG, because of its flexible design, should be able to take a beating. “It works the best with the worst weather conditions,” says Wang.
But if TENGs can withstand the sea, Wang doesn’t have a solution to the financial problems that torpedoed projects in the Bay of Fundy, the islands of Scotland, and other initiatives that seemed promising at first. “People ask me, can you demonstrate it?” he asks. “I say, no, I don’t have funding for that.”
And ultimately, it’s not the swells of the ocean that remains the most formidable challenge; it’s the finite finances of would-be sponsors. So even if physicists and engineers can tame the sea, they’ll have to persuade funding bosses, business executives and the public that it’s worth pumping money into harvesting energy from the Earth’s waters. “For wave and tidal machines to be perfected through testing and demonstration,” says Buck, “the sector requires full support from government and society alike.”
Speed of spreading epidemics is predicted using analytical technique
Two UK-based mathematicians have developed an analytical technique that can be used to calculate how fast an infectious disease can spread on a global level. Sam Moore and Tim Rogers at the University of Bath have shown that their calculations are better than computationally-intensive numerical models at predicting how infections will progress within real-world scenarios. Their work could lead to the development of protocols that could help authorities to prevent the rapid spread of diseases such as the COVID-19 coronavirus.
Ever increasing global and regional travel is a reality of modern life and provides infectious diseases with the opportunity to spread rapidly throughout the global population. The burgeoning field of “network epidemiology” aims to understand how this spreading occurs using a wide range of mathematical techniques. These methods have yielded useful results when applied to smaller-scale outbreaks. However, model networks become vastly more complex as they increase in size and huge computational resources are often needed to simulate epidemics on a global scale.
In their study, Rogers and Moore have taken an analytic approach to predicting the speed of disease, with the aim of reducing the need to do huge numerical simulations. They used a concept in network epidemiology that uses branching, tree-like networks to define the degrees of connection separating individuals from a central source. Even in our highly connected world, most people will come into close contact with a small number of other individuals. This sparseness of contact has been characterized using a “message passing” approach, which captures important aspects of how real diseases spread. While this approach had yielded important insights into disease outbreaks, until now it had not been used to calculate the speed of spread.
Updated equations
The duo adapted current message-passing analysis to account for the mean delay in infection between individuals, at different degrees of connection from the central source. Their updated equations allowed them to determine the times at which a simulated infection is most likely to arrive at certain individuals. Their showed excellent agreement with numerical simulations of real-world networks; even for densely populated communities, where webs of interaction become more complicated.
Moore and Rogers demonstrated the versatility of their approach by successfully modelling the particularly complex case in which individuals only become infected after interacting with multiple people with the disease. In addition, they showed that the time taken for an infection to spread throughout the bulk of a population shows no dependence on network size. Rather, the jump from just a few, to many infected individuals can happen almost instantaneously.
The duo hopes that their results will pave the way to more detailed multi-layered and time-varying models. If achieved, they predict that routes towards the development of monitoring and prevention protocols for real-world diseases could soon emerge.
The research is described in Physical Review Letters.
FDG-PET displays its prowess in dementia detection

In a direct comparison, FDG-PET proved superior to MRI with arterial spin labelling (ASL) for diagnosing and differentiating various forms of dementia; however, there remains a need for the latter modality, according to a Belgian study published in the European Journal of Nuclear Medicine and Molecular Imaging.
Two readers achieved higher sensitivity and greater diagnostic confidence using FDG-PET against MRI with enhanced multiplane tagging ASL (eASL), which is used to quantify cerebral blood perfusion. Yet, despite the differences, the researchers still believe MRI with eASL can play an important role in dementia diagnosis.
“Within the setting of this clinical study on subjects referred for suspicion of neurodegenerative dementia, the main finding was that F-18-FDG-PET should still be seen as the primary choice, as it performed better compared with eASL in terms of sensitivity, reader confidence, and lower variability in key regions in dementia diagnosis,” wrote lead author Jenny Ceccarini and colleagues at University Hospitals Leuven.
“Moreover, eASL could be considered a potential alternative to F-18-FDG-PET to assess neurodegeneration in patients with cognitive impairment when the latter is unavailable, or in case dual-parameter evaluation may still serve as complement to neuroreceptor or protein deposition PET studies when a single simultaneous investigation is performed,” they noted.

Diagnosing dementia
PET with FDG and various other radiotracers has been used to attempt to diagnose the early onset of Alzheimer’s and dementia. At the same time, perfusion MRI with ASL has been used to indirectly measure neuronal functioning, but its diagnostic value in clinical dementia diagnosis has not been determined, the researchers noted. They cited previous studies in which sensitivity ranged from 53% to 80% and specificity from 62% to 84%, “probably due to differences in ASL techniques, type of comparative analysis, and due to the heterogeneity of small cohorts”.
Given that few PET/MRI studies have compared FDG-PET with MRI using ASL, Ceccarini and colleagues sought to conduct a head-to-head comparison between eASL and F-18-FDG-PET in the clinical context of subjects who were referred for suspected neurodegenerative dementia, they added.
The prospective study included 27 patients (mean age, 64.3 ± 11.2 years) referred for a brain scan between December 2016 and June 2017 due to recent cognitive decline and possible dementia. The routine, 20-minute PET/CT scan was performed 30 minutes after injection of 150.5 (± 11.5) MBq of F-18-FDG; this was followed immediately by a PET/MRI scan on a simultaneous 3-tesla system (Signa, GE Healthcare), which featured an eASL sequence.
The patients also underwent routine clinical, neurological and neuropsychological exams, with some also undergoing structural MRI with T1-weighted and fluid-attenuated inversion recovery (FLAIR) sequences. In all, 14 patients had a neurodegenerative cognitive disorder – Alzheimer’s disease, Lewy body dementia or frontotemporal dementia – and 13 had no evidence of neurodegeneration.
In addition, the study included 30 healthy control subjects who were matched by age and gender to the patient cohort. The control subjects underwent a 60-minute PET/MR scan some 60 minutes after injection of 152.2 (± 11.1) MBq of F-18-FDG.
Seeing is believing
The two readers, who were blinded to the final diagnoses, evaluated the MRI-eASL and FDG-PET results by determining the presence and degree of dementia. The readers also rated their diagnostic confidence in using the two approaches on a scale of 1 to 4.
In the visual read of images to distinguish between normal results and neurodegeneration, the duo achieved a mean sensitivity of 93% with FDG-PET, compared with a significantly lower mean sensitivity of 64% with MRI-eASL (p = 0.03). Mean specificity was fairly consistent between the two modalities, with FDG-PET at 70% and MRI-eASL at 71%. Mean accuracy was 75% with FDG-PET, compared with 68% for MRI-eASL, but the difference was not statistically significant.
One reader diagnosed nine (64%) of the 14 patients with confirmed cases of dementia using FDG-PET, while the other reader accurately called eight (57%) of those patients. The pair had less success with MRI-eASL, correctly diagnosing seven (50%) and four patients (29%), respectively, with confirmed dementia.
Reader confidence
For several regions of the brain associated with dementia, the readers’ diagnostic confidence waned with MRI-eASL. They were less confident in their conclusions when using eASL to rate blood flow, compared with FDG metabolism, in the temporal cortex, occipital cortex, striatum and thalamus among all patients with a suspected diagnosis of dementia and among the entire control group.
Ceccarini and colleagues cited several factors that distinguish these results from previous research. First, the prospective study was conducted “in a true clinical context of patients with cognitive impairment referred for exclusion/confirmation of a neurodegenerative disorder after careful clinical and paraclinical workup,” they wrote.
“Moreover, we included an age- and gender-matched healthy control set acquired on the same instrumentation that was evaluated in a blinded fashion and the heterogeneity of final diagnoses represents a true clinical scale of uncertain cases with cognitive impairment,” the authors added.
- This article was originally published on AuntMinnieEurope.com ©2020 by AuntMinnieEurope.com. Any copying, republication or redistribution of AuntMinnieEurope.com content is expressly prohibited without the prior written consent of AuntMinnieEurope.com.
Tackling the grand challenges

At the American Physical Society’s recent annual leadership meeting in Washington, DC, you spoke about collaboration and international competition. Given that some US scientists are encountering issues by having ties with China, how is it possible to balance the two?
We need to appreciate that there are costs and benefits of collaborating with some countries. The benefits are that we need smart people to create new knowledge and we want the US to attract the world’s best scientists – after all, that is what gave us our scientific excellence. There is nothing wrong with that, but sometimes you have a very small fraction of people who are bad apples, so what do you do? If most scientists are ethical then you can use peer pressure, but sometimes it may take more, such as training and coaching.
Is there anything that scientific societies can do to help?
Yes. I am currently president of the American Association for the Advancement of Science and I am working with other societies to define what good standard behaviour is. It is not acceptable to make fraudulent data and cherry pick your data. Honesty in publication is essential as is the replication of results. If it is not possible to repeat the experiment, then say why. These are things you can teach, even if standards on what is acceptable sometimes differ from field to field.
So how might we protect ideas and intellectual property?
Basic research is good for the country and good for the world and I believe that if you have good people you can make the most out of shared knowledge. If you have an original idea and someone wants to undercut you and throw more resources at it before you get published, then we need to have a consensus among the worldwide science community that this is not right.
As former head of the US Department of Energy, you helped to launch the Sun Shot programme. Do you think it has been a success?
Sun Shot had the goal of reducing solar-energy costs by 75%. The idea was to look at whether that would be possible via research but also by talking with solar manufacturers. We found that while module costs were plunging, installation costs were going much slower. So we looked at Germany’s success with roof-top solar panels. We knew that Germany’s labour market costs were similar to the US, so we studied what they did. We saw that they were spending a third of the time to install such systems compared to here in the US. Due to this technical focus on the whole-systems costs, we reached the Sun Shot goal within seven years, although this was also partly due to China getting active and driving down prices for solar panels.
What about another programme you helped launch – the Advanced Research Projects Agency–Energy (ARPA-E)?
ARPA-E is more complicated than Sun Shot to gauge its success. For ARPA-E we are “swinging for the fences” – to coin a baseball term for hitting a home run – looking at what sort of technology to focus on that could be a decade or two before it becomes transformative. If you are swinging for the fences, you want radical proposals, not incremental ones. If you are willing to accept that just one in 10 are going to succeed, then you need a different kind of review process than peer review as well as programme managers who need to stay on top of the research.
What came out of the programme – any early successes?
There were some radical new things. One example is drilling. When you think about drilling you normally think about natural gas, but there are other areas such as tapping into geothermal. One group had the idea of using a laser, in which case you do not need to put as much weight on the drill bit to grind through the rock. It could be transformative in lots of ways but it’s too early to tell whether it will be successful. Another area is in electric vehicles, which are currently working at 600 V. If you could go higher in voltage, the wires can be lighter and therefore more efficient.
What are some of the energy challenges currently facing the US?
We don’t yet have substitutes for cement, chemicals or plastics, and we have to consider aeroplane emissions, so it has become urgent to install carbon capture and sequestration. You don’t want to start by capturing carbon out of the atmosphere – it costs three times as much as capturing it from concentrated sources. So you need to target point sources such as fossil-fuel plants. But we first need to get experience doing it and creating business models.
What about other urgent issues?
We need to tackle high-temperature refrigerants – those that can work in South Asia and sub-Saharan Africa. Why do we care about that? As South Asia and sub-Saharan Africa get richer, they will want air conditioning. Yet the air-conditioning efficiency in these regions decreases because the refrigerants are not optimized for temperate climates. Western refrigerator companies aren’t going to do this research because rich countries are in temperate zones.
Are you optimistic for the future?
I am hopeful that things will get better and I see more smart people recognizing the need to solve problems around climate change.
- You can watch Steven Chu’s plenary talk at the APS leadership meeting in full on YouTube.
Delegates react after last-minute cancellation of American Physical Society March Meeting
Thousands of delegates to the March Meeting of the American Physical Society (APS) in Denver have had to cancel flights to Colorado or rearrange their journeys home after the decision to cancel the world’s biggest physics meeting.
The APS’s decision to abandon the event was taken late on Saturday 29 February, less than 36 hours before the meeting in Denver was due to start. It was cancelled “with deep regret” due to what the society said were “rapidly escalating health concerns” over the spread of the coronavirus COVID-19.
The March Meeting – the biggest in the physics calendar – is usually attended by about 10,000 delegates from all corners of the globe, including many from China, where the virus originated.
“The health and well-being of our meeting attendees, staff, vendors, and the Denver community are our primary concern,“ said APS president Phil Bucksbaum in a statement released on Sunday afternoon. “We recognize and sincerely regret that the timing of this decision has significantly inconvenienced many members of our community.”
Concerns raised

But the late cancellation prompted a strong reaction from many attendees, especially those from overseas who only found out once they were on their to way Denver or who had already arrived.
“I completely understand this decision taken, but the timing on this is appalling,” tweeted Ilana Wisb, chief executive of the UK firm Oxford Quantum Circuits. “Our team have just flown half way across the world to learn that this is cancelled on landing.”
Matthew Wright, a physicist at Adelphi University in New York, said the last-minute cancellation had led to a “chaotic shit storm of travel changes for me and my undergrad students”. He claimed on Twitter that the APS will get “some serious heat” for the decision, but admitted “it was likely the right thing to do”.
Other delegates, like Zhe Li, a biophysics PhD student at Purdue University, wondered why other international events, such as the Geneva Motor Show, were cancelled weeks or months before they were due to take place. “APS should have done the same thing,” he tweeted.
Meanwhile, Santiago Núñez-Corrales, a PhD student at the University of Illinois Urbana-Champain, expressed concern over the financial impact on students. “This tardy cancellation, while responsible in terms of wider health concerns,” he said, “has profound consequences for us graduate students by increasing financial vulnerability as many people paid out of pocket from limited stipends, and will have to contend further expenses to get back.”
But others on Twitter defended the APS’s decision. Masaki Oshikawa, a solid-state physicist from the University of Tokyo in Japan, tweeted that “given the current situation in the US and in the world, this is a right decision. It must be very hard to cancel such a big and important meeting at the very last minute, but kudos to APS for the swift decision.”
Eerie and empty
Over at the Denver Convention Center, where the March Meeting was due to take place, the corridors were eerily silent on Sunday morning as delegates who were in Denver took stock of the cancellation.
“Cancelling the event didn’t surprise me but this would have been a big decision for the APS to make and not one they would have made lightly,” Daniel Lathrop from the University of Maryland told Physics World.
As chair of the APS’s topical group on statistical and nonlinear physics, Lathrop and colleagues had organized more than 50 sessions, each featuring about a dozen different speakers. He particularly regretted the fact that eight talks by students and postdocs who had won prestigious awards from the group were unable to take place.
“The APS March Meeting is an important event that leads to the exchange of ideas, especially among young scientists,” Lathrop said. “Some of our awards stipulate that winners have to give a talk, which is a real chance for them shine and advance their careers. We need to find a new venue for them to appear.”

In the cavernous exhibition hall, fork-lift trucks spent Sunday shifting packing cases out of the building, while a handful of staff from physics-based companies loitered wondering what to do next.
One of those firms affected by the cancellation was Qblox, a start-up business from the Netherlands, which makes electronics to control quantum chips.
The company’s five staff had spent three weeks working flat-out to create a demonstration for the exhibition and had spent more than €18,000 on exhibition space, flights, travel, hotels and shipment.
“I can fully live with the decision to cancel the meeting, which makes perfect sense, but if we had been told just 24 hours earlier, that would have made a tremendous difference, not just financially but in terms of time,” says quantum physicist Niels Bultink, who founded Qblox in 2018.
Despite his disappointment, Bultink still thinks that the March Meeting is vital for firms like his to showcase their wares. “I hope the March Meeting can be postponed till the summer – that would be the best outcome. The event helps to focus our minds as a company and fortunately all the time we invested is not wasted.”
American Physical Society cancels March meeting in Denver due to coronavirus outbreak
The American Physical Society (APS) has cancelled the world’s biggest physics conference, which had been due to take place in Denver, Colorado, from 2-6 March.
It decided to cancel the meeting late on Saturday 29 February due to “rapidly escalating health concerns relating to the spread of the coronavirus disease (COVID-19)”.
The APS said it took the decision “with deep regret” and admitted that the timing of the decision will have “significantly inconvenienced” many delegates. The APS March meeting is normally attended by some 10,000 physicists from around the globe.
Previous statements from the APS had said the meeting would be going ahead, although a “no-handshake” policy had been in place and physicists were given other health advice and tips.
However, the APS decided to cancel the meeting “based on the latest scientific data being reported” about the virus’s spread. The decision was also made based on the fact that many attendees come to the APS March meeting from outside the US, “including countries where the Centers for Disease Control and Prevention (CPC) upgraded its warning to level 3″. These are currently China, Iran, Italy and South Korea.
APS delegates have been promised “a full refund” of registration fees, while the society will investigate whether delegates can be reimbursed hotel fees.
The APS was founded in 1899 and is the world’s biggest organization of physicists. The annual March meeting is one of the highlights in the physics calendar, attended by thousands of physicists in areas such as condensed matter, materials, atomic physics and quantum physics.
There is also a big exhibition of hi-tech companies attended by physics-based firms such as Oxford Instruments, Kimball Physics, Q-CTRL and Quantum Design.
Journalists and other staff from Physics World, which publishes an annual careers guide in partnership with the APS, had already travelled to the meeting.
Freeman Dyson dies age 96
The mathematical physicist and public intellectual Freeman Dyson has died at age 96 today. He spent most of his professional career at the Institute for Advanced Study in Princeton, New Jersey where he was Professor Emeritus.
Born in Crowthorne, Berkshire in 1923, Dyson obtained a BA in mathematics from the University of Cambridge. He then moved to the US where he studied for a doctorate with Hans Bethe at Cornell University. However, he did not complete his degree and went on to be one of the world’s most famous physicists despite not having a PhD.
Dyson’s early work focused on quantum electrodynamics and he also applied mathematics to the study of nuclear reactors, solid state physics, ferromagnetism, astrophysics and biology. He is the author of several popular books on physics.
In 2006 Dyson published The Scientist as Rebel in which he questioned the science of global warming, putting him in conflict with the scientific consensus.
Dyson has several concepts named after him including the “Dyson tree”, which is a hypothetical genetically-modified plant that lives inside a comet. He also popularized the idea of a huge artificial structure that could be built around a star by an advanced civilization – now known as a “Dyson sphere”.
In 2000 Dyson won the Templeton Prize for his writing on the intersection of science and religion.