Skip to main content

Artificial intelligence spots unusual feature at Earth’s core-mantle boundary

An artificial intelligence algorithm originally developed for astrophysics has revealed a previously unknown feature on the core-mantle boundary deep inside the Earth. The algorithm allowed researchers in the US to find patterns in seemingly unconnected seismic data from different sources and the team believes that the new technique could glean insights from other types of geophysical datasets in future.

The motion of tectonic plates continues to shape the surface of the Earth and this activity is monitored constantly by a worldwide network of seismometers. Studying how seismic signals travel through the different layers of the Earth has informed much of our knowledge of the structure of Earth’s interior. In the early 20th century, for example, researchers inferred that the Earth has a liquid outer core because shear waves from an earthquake were not detected by seismometers on the opposite side of the globe – because a liquid cannot shear.

As seismology has grown more sophisticated and more monitoring stations have been installed, researchers have discovered much more about Earth’s interior, such as physical stratification and plumes of rising hot material within the mantle and mysterious “ultra-low velocity zones” on the core-mantle boundary, where waves travel much more slowly than expected. “They’re inferred from the data but we don’t really know what these things are,” says seismologist Doyeon Kim of University of Maryland, College Park, who led the latest research.

Ever-growing volume of data

Researchers normally make such deductions from patterns of seismological signals that clearly stand out to a human observer. However, the ever-growing volume of seismic data from across the world may contain patterns that humans cannot perceive. Kim and colleagues therefore worked with astrophysicists at Johns Hopkins University in nearby Baltimore to apply a computer algorithm called the Sequencer developed by astrophysicists. Last year, the algorithm revealed a previously unknown relationship between the masses of supermassive black holes and the properties of their host galaxies.

In a paper published in Science, the team describes how the Sequencer systematically sifted through thousands of seismic signals of diffracted waves, measuring the value of a specific quantity called the Wasserstein metric. Then it played a mathematical game of join the dots – finding the shortest path between all the data points. When there was clearly one optimal path, this showed a trend in the data.

When the researchers focused on signals beneath the northern Pacific Ocean, two regions stood out as strong generators of diffracted, delayed waves called postcursors, which are produced when seismic waves interact with anomalous structures. The first is beneath Hawaii. This was known to host a seismic wave anomaly, but data from the Sequencer — as well as additional analysis — shored up the hypothesis that it may result from a mantle plume and helped to localize it more precisely.

“Mega ultralow-velocity zone”

The second notable anomaly is, they believe, a previously unknown “mega ultralow-velocity zone” beneath the remote Marquesas Islands in French Polynesia. Scientists already know of some similar zones — beneath Iceland and Samoa, for example – that have been associated with areas of highly unusual geochemical compositions. This has led to suggestions these features may harbour material predating the giant impact on Earth that is thought to have formed the Moon. The new discovery beneath Marquesas, suggests Kim, could potentially test this hypothesis.

Kim explains the work is part of a trend in many sciences towards the use of artificial intelligence to optimize search strategies and find patterns in data that elude humans. “Broadly speaking in seismology and geophysics in general, we use supervised machine learning to search for ‘labelled’ objects such as earthquake signals from seismic recordings,” he explains, “However, where it gets interesting is in unsupervised learning, where we don’t know what we’re looking for in our datasets. That’s where this algorithm fits – you’re looking at datasets as points in a high-dimensional space and looking for patterns and clusters.” He says a forthcoming paper by the Johns Hopkins researchers describes how the Sequencer was used to sort samples of another type of earthquake wave called surface waves.

“This is very innovative, and represents a direction we need to go in seismology,” says earth scientist Edward Garnero of Arizona State University in the US. “Methods like this may help us to find things we may not even have been looking for – and apparently they did.” He is cautious, however, about the assumption that the delay in the postcursor signals came solely from the core-mantle boundary, wondering whether mantle heterogeneity elsewhere might have played a role. Ultimately, he says: “In seismic modelling, we are always up against the issue of knowing if our favoured solution model is [both] unique and the real earth.”

Physicists propose how to entangle macroscopic objects using pulses of light

Physicists at Imperial College London, UK, and Stockholm University, Sweden, have proposed a new way of creating entanglement between mechanical motion and an optical field, and also between two mechanical oscillators, using short pulses of light. Here research students Jack Clarke and Paulo Sahium along with group director Michael Vanner from the Quantum Measurement Lab at Imperial explain the work.

The research is reported in full in New Journal of Physics, published by IOP Publishing – which also publishes Physics World.

What was the motivation for the research?

Quantum entanglement is one of the most intriguing aspects of physics and allows objects to be more strongly correlated than is allowed classically. Albert Einstein called this perplexing behaviour “spooky action at a distance” and many objections to this radical idea were raised in the early days of quantum mechanics. Fast forward 80 years, and quantum entanglement is a now a well-established phenomenon and is routinely generated between objects such as photons, atoms and molecules.

Making an entangled state of something bigger allows us to test quantum physics on a macroscopic scale and paves the way for the development of powerful new quantum technologies, such as sensing and quantum networking. In this work, we propose a new technique to create such quantum states by using quantum optomechanics. In our scheme, light bounces off two tiny mechanical oscillators causing them to move, creating an entangled state in their motion. 

What did you do in the work?

It is a very exciting time in quantum optomechanics at present, as early signatures of quantum motion of mechanical oscillators are now being observed. In this work, we theoretically proposed and analysed a powerful new approach to create entanglement between mechanical motion and an optical field, and also between two mechanical oscillators, using short pulses of light.  

With this work, we have laid the foundation for future experiments in this area by showing how to both generate and, importantly, verify the entanglement. To make this a more useful study, we also dived into the details and computed the effects of optical loss and mechanical quantum decoherence on the quantum states. We are very encouraged by these results, as our schemes offer many advantages including being able to operate with weak optomechanical coupling, and being resilient to optical loss and mechanical decoherence.  

What was the most interesting or important finding?

Our research is the first theoretical proposal for preparing and verifying mechanical and optomechanical entanglement in the emerging field of pulsed optomechanics. This highlights a route to observe quantum entanglement in a regime where it hasn’t been seen before. 

More specifically, there are two main regimes in quantum optomechanics. One is the “resolved-sideband regime”, where light circulates inside an optical cavity for a timescale that is long compared to the mechanical period. The other is the “unresolved-sideband regime”, which allows for rapid pulsed interactions over a timescale much shorter than the mechanical period. Optomechanical entanglement has not yet been observed in this latter regime and our work makes key steps in this direction. One of the most important results from our work is that in the pulsed regime creating such entanglement looks experimentally accessible, and is robust to effects that often hinder its observation. 

Why is this research significant?

Entanglement can be exploited to develop new quantum technologies such as quantum networks and quantum-enhanced force sensors. Studying it also allows us to address very fundamental questions, such as “what are the limits of quantum theory?” To these ends, a key current goal of research is to create and observe entanglement on larger and larger mass scales. Quantum optomechanics has significant potential to contribute to both areas, which helps to make it such an exciting field. This research project makes a significant step in these directions, as it opens a rich new avenue for studies of optomechanical entanglement in the pulsed regime. 

What do you plan to do next?

In our research groupthe Quantum Measurement Labwe pursue a combination of experimental and theoretical quantum science to advance our understanding of the foundations of physics and to leverage this understanding to develop new quantum technologies.  

We will build on our research in three key ways. First, our results have sparked new theoretical questions on optomechanical entanglement creation and its verification, which we have begun investigating. Second, it’s a very exciting time for our group at present as our new lab in London has completed a refurbishment phase and we are eager to build experiments in these directions once the current coronavirus pandemic is over. Third, we hope our research in pulsed optomechanics inspires other experimental groups around the world and that we will engage with our global research community to initiate new collaborative projects.

The full results are reported in New Journal of Physics.

CERN approves further work on Future Circular Collider – but delays final decision

The CERN Council has today approved an update to the European Strategy for Particle Physics that recommends further work on a huge 100 km collider – dubbed the Future Circular Collider (FCC) – that would be built in Geneva. But with no formal decision having been made to go ahead with the FCC, the strategy also calls for Europe to back a Japanese-led linear collider if it receives the go-ahead from the Japanese government.

The report, released this morning, sets out a plan for the future of particle physics in Europe to the mid-2020s and beyond. It especially concerns planning the next collider that would succeed the Large Hadron Collider, which first switched on in 2008. The 27 km-circumference LHC has been smashing protons together at energies up to 13 TeV in the hunt for new particles and in 2012 physicists announced they had discovered the Higgs boson with a mass of 125 GeV.

The LHC is currently undergoing a major £1.1bn “high luminosity” upgrade – dubbed HL-LHC – that will increase the collider’s luminosity by a factor of 10 over the original machine. The strategy indicates that the completion and exploitation of the HL-LHC should remain “the focal point of European particle physics”.

The strategy update, however, gives the green light for further study into the FCC, which would cost around £20bn. In January 2019, CERN released a four-volume conceptual design report for the FCC, which first called for the construction of a 100 km underground tunnel that would house an electron–positron collider (FCC-ee). The FCC-ee would focus on creating a million Higgs particles to allow physicists to study its properties with an accuracy an order of magnitude better that what is possible today with the LHC.

Once the physics programme for the FCC-ee is complete, the same tunnel could then be used to house a proton-proton collider, dubbed FCC-hh. The FCC-hh would use the LHC and its pre-injector accelerators to feed the collider that could reach a top energy of 100 TeV – seven times greater than the LHC. CERN will now carry out a more detailed costing of the FCC as well as continue research and development into the magnet technology that will be required for such a machine at higher energies.

Eyes on Japan

The strategy also approves European participation in the ¥800bn ($7.5bn) International Linear Collider (ILC) if it receives support from the Japanese government. First mooted over a decade ago, the ILC would accelerate and smash together electrons with positrons at 125 GeV in a 20 km tunnel to study the Higgs boson and other particles in precise detail.

In March 2019, officials in Japan said that their government has formally “expressed an interest” in the particle smasher but did not decide whether to host the machine. The final go-ahead will only be given if enough international support and funding can be found to construct the machine and there is a consensus within the Japanese scientific community that the project is worth pursuing.

The European strategy is to prepare a Higgs factory, followed by a future hadron collider.

Halina Abramowicz

Yet backing the FCC does not contradict supporting the ILC as the two could be complementary. If the ILC is given the green light, then CERN could opt to bypass the FCC-ee and build the FCC-hh after the LHC programme is complete. “The European strategy is to prepare a Higgs factory, followed by a future hadron collider with sensitivity to energy scales an order of magnitude higher than those at the LHC,” noted Halina Abramowicz, who is secretary of the European particle physics strategy update.

“What this [decision] is about is prioritizing the R&D for what comes after the LHC, it’s not proposing a new machine right now,” physicist John Butterworth from Univeristy College London, who sits on the European strategy group, told BBC Radio 4. “It’s looking at what we have learned, looking at the technologies that we think we might need, where should we be prioritizing our resources for what we might want to do after the LHC”.

End of CLIC?

However, the decision to prioritise the FCC and back the ILC if Japan gives the go-ahead,  puts the CERN-led Compact Linear Collider – another linear collider proposal – as a “plan B”. CLIC is not as technologically mature as the ILC, but could run at higher energies. It is now only likely to go ahead if the FCC turns out to be too costly and the ILC is not given the go ahead by Japan.

An electron-positron collider Higgs factory as highest priority for our field is clearly the way forward

Philip Burrows

Philip Burrows from the University of Oxford, who is CLIC’s spokesperson, says he congratulates the European Strategy group on their “careful deliberations and clear recommendations”. “An electron–positron collider Higgs factory as highest priority for our field is clearly the way forward,” Burrows told Physics World. “The options for CLIC as a CERN-based Higgs factory, and subsequent energy-frontier exploration collider, are clearly articulated, and the door is opened wide for Europe to make major contributions to ILC should Japan go ahead and realize ILC as a global project. Either way we can plan to realise a linear collider Higgs factory.”

Particle theorist John Ellis from King’s College London told Physics World that he is “happy” with the proposal to support a Higgs factory and prepare for a high-energy collider at CERN. “CLIC is de-emphasized, though not explicitly dropped,” he says, adding that the ILC is mentioned “only as something with which the European particle physics community would wish to collaborate, without any commitment by CERN”.

CLIC is de-emphasized, though not explicitly dropped.

John Ellis, King's College London

The FCC, CLIC and the ILC are not the only proposals for a future high-energy collider. Physicists in China unveiled the conceptual design for its own 100 km tunnel in September 2018. It would first house an electron–positron machine before hosting a proton–proton collider operating at 100 TeV. If it gets the go-ahead, construction of the Chinese collider could start before the the FCC.

The European strategy was originally due to be announced in May, but this was postponed due to the COVID-19 pandemic.

MR-guided focused ultrasound treats psychiatric disorders

MR-guided focused ultrasound (MRgFUS) is a novel surgical technique that can be used for incision-free ablative neurosurgery. Two Phase I clinical trials conducted at Sunnybrook Research Institute have demonstrated that MRgFUS appears to be safe and effective for patients with treatment-resistant obsessive compulsive disorders (OCD) and major depressive disorder (MDD). Of 12 study participants who underwent MRgFUS bilateral anterior capsulotomy, half reported an improvement in their quality-of-life.

Anterior capsulotomy, an established neurosurgical procedure, creates a lesion in a brain pathway known to be involved in OCD and MDD. This region, the anterior limb of the internal capsule (ALIC), connects key areas of the brain involved in anxiety and regulation of emotions. The lesion, which is usually created using radiofrequency (RF) ablation or stereotactic radiosurgery (SRS), interrupts the ALIC fibres to help reset abnormal communication in the brain.

Treatment with MRgFUS does not require the invasive surgery needed for RF ablation, and does not expose a patient to the high radiation doses of SRS. Performed inside an MRI scanner, MRgFUS uses MR imaging to guide multiple high-powered ultrasound beams to a small target, to achieve controlled heating and ablation.

For the procedure, patients wore a helmet fixed over a rigid headframe. The helmet contains 1024 ultrasound elements that target brain regions with millimetre accuracy. The team performed three low-powered test sonications, which raised the temperature of the targeted region to 40–45°C, to align the sonication focus and confirm targeting accuracy. They then performed higher powered sonications to raise temperatures to over 53°C and create lesions. These were repeated based on the temperature rise, estimated thermal dosing and patient tolerance. They used T2-weighted MRI and real-time thermography to confirm the accuracy of the lesion targeting.

The treatments, performed at Sunnybrook Health Sciences Center, took three to four hours. The researchers treated 16 patients in total, but the procedure was not successful for four of them due to insufficient MRgFUS heating at the target site.

Writing in Molecular Psychiatry, the researchers report interim six-month post-treatment findings from their 12 month trial. They found that patients with OCD responded better to MRgFUS capsulotomy than those with MDD, with 66% and 33% of patients, respectively, achieving a significant treatment response.

None of the patients experienced any serious treatment-related adverse effects, reports principal investigator Nir Lipsman, director of Sunnybrook’s Harquail Centre for Neuromodulation. Seven patients reported swelling at the site of the headframe pins and headaches for several days, and one patient experienced mild headaches for several months.

Four of the six OCD patients experienced a more than 35% reduction in their Yale-Brown Obsessive Compulsive Scale (YBOCS), and two patients with MDD had a greater than 50% reduction in their Hamilton Depression Rating Scale (HAMD17). Improvements in YBOCS and HAMD17 scores also were generally accompanied by measurable improvements in mood, anxiety and quality-of-life. No negative cognitive or behavioural effects were experienced by nine patients who underwent neuropsychological testing.

The studies also showed that MRgFUS capsulotomy lesions led to significant metabolic and functional alterations in brain circuits governing affective processing, and that pre-operative functional connectivity – measured using resting-state functional MRI – could differentiate treatment responders from non-responders.

“These findings suggest that a focal lesion in bilateral ALIC can have widespread effects on glucose utilization, supporting the notion that OCD and depression are indeed circuit conditions in the brain, and that influencing key nodes in that circuit can have brain-wide effects,” comments Lipsman.

“Our study supports the importance of continued research into focused ultrasound as a safe and innovative treatment approach for patients with difficult to treat OCD and depression,” he adds. “Patients with these debilitating neuropsychiatric conditions have tried conventional treatments without success and are in need of novel treatment options.”

Lipsman tells Physics World that following these initial trials, the next steps will be to expand to larger patient populations and more comprehensively study both the safety and efficacy of MRgFUS in treatment-resistant psychiatric disorders. “More patients, in more centres, and with comprehensive study of responses prior to and after treatment will help inform what role MRgFUS may play in the care of these patients,” he says.

Metasurface laser produces super-twisted light

A new metasurface laser can produce light in any desired angular momentum state, including highly chiral or “twisted” light capable of manipulating physical objects. According to its developers at the University of the Witwatersrand (Wits) in South Africa and Harvard University in the US, this tunable, high-angular momentum light source could also be used to encode information in optical communications.

The angular momentum of light is the sum of two independent components: spin angular momentum (SAM) and orbital angular momentum (OAM). SAM is associated with circularly polarized light and arises when the electric and magnetic field vectors of light rotate over the course of a wavelength. Because SAM can have only two values – right or left circular polarization – its applications are relatively limited. OAM, on the other hand, results from the rotation of a light wave’s phase, and can take on any value. This variability makes OAM useful for a wider range of applications, including “optical spanners” – devices that trap and rotate tiny particles using light – and transferring data through optical fibres without crosstalk (multiplexing), to name but two examples.

Challenges of producing OAM states

The flexible nature of OAM means that a beam of light can, in principle, carry an unlimited amount of angular momentum. In practice, however, dialling up a desired OAM state is far from easy, explains study co-leader Andrew Forbes from Wits’ School of Physics. While various techniques exist, their efficiency – the proportion of light converted into the desired state – is limited. Alternatively, a device known as a q-plate can transform SAM into OAM with up to 100% efficiency, but it only works with pure right or left circularly polarized light. Because real light beams often have intermediate (elliptical) polarization, this is a significant drawback, since adding a fixed amount of OAM to one spin state and an equal and opposite amount to the other produces a net angular momentum of zero.

New forms of chiral light and the highest AM

The new device overcomes these obstacles by incorporating a metasurface – an artificially engineered nanostructure that interacts with light in unusual ways – into the laser cavity. The design of this metasurface builds on the Harvard group’s previous work and consists of rectangular amorphous pillars of TiO2 just 600 nm high. These nanopillars are separated by distances shorter than the wavelength of light being modulated, and they act like optical antennas – introducing spatially varying phase delays in the light rays that pass through them and moulding the light beam according to the desired profile. “In our experiment, we pass light through the metasurface many times, giving it a new twist in its phase each time we do so, while controlling the polarization of the light at the same time,” Forbes explains.

The result is a device that produces two output beams with OAM values that differ by as much as 90 units, resulting in a large non-zero total angular momentum. According to Forbes, this is the first laser that can produce such highly chiral light in any desired angular momentum state. “One of our demonstrations was a laser beam with OAMs of 10 and 100 in the same beam (with horizontal and vertical polarizations respectively),” he tells Physics World. “The prior record was just +10 and -10 (and therefore zero total AM).”

According to Federico Capasso, the study’s other co-leader and a professor of applied physics at Harvard, the use of metasurfaces was “the determining factor” in achieving a record-high optical angular momentum, L, of 100. “Alternative technologies such as q-plates and spatial light modulators (SLMs) have not even come close to these values of L,” he says. “What is more, the design limitations and fabrication constraints of those technologies can’t give the arbitrary wavefront control provided by metasurfaces, of which the non-symmetric vector vortex beams described in this paper are an outstanding example.”

Dramatically reducing light losses

According to Harvard’s Yao-Wei Huang, who constructed the metasurface used in the laser, the new design “demonstrates the highly effective coupling between arbitrary spin (a linearly, circularly, or any elliptically polarized state) and orbit (symmetric or non-symmetric helicity) of light in a compact planar structure”. Forbes adds that the device can couple non-symmetric OAM to linearly polarized states, rather than being limited to symmetric OAM and circularly polarized states, as q-plates are. “This may seem like a minor technical detail, but it means we can halve the number of elements inside the laser, so dramatically reducing light losses and allowing us to reach OAM values of 100 (a x10 advance over the prior state-of-the-art from such lasers),” he explains.

According to Forbes, another interesting feature is that the beams carrying 10 and 100 units of angular momentum are significantly different in size when they come out of the laser. When they travel around the cavity, however, they converge to a similar shape and size, where they experience optical gain. This allows for a coherent mode – a tell-tale sign of lasing – even though the actual beams appear spatially separated.

“We can use this type of light to optically drive gears in situations where physical mechanical systems would not work, such as in microfluidic systems to drive flow,” he explains. “Such systems could be used to make miniature lab-on-a-chip devices in which medicine would be performed on a single chip rather than in large experimental apparatus in the lab.”

The laser, which is described in Nature Photonics, could also be made bigger by increasing the size of the metasurface and the gain volume to produce a high-power bulk device. “In both these cases, the lasing mode wouldn’t require any intra-cavity elements other than the metasurface itself,” Forbes says.

Neutrons join the battle against COVID-19, firm aims for a million-qubit quantum computer, cyanobacteria power a solar cell

In this episode of the Physics World Weekly podcast Giovanna Fragneto explains why neutrons are an ideal probe for studying the SARS coronavirus that is responsible for the COVID-19 pandemic. Fragneto is leader of the Large Scale Structures group at the Institut Laue-Langevin, which is a world-leading centre for neutron science in Grenoble, France. In the podcast she mentions a recent webinar from the League of Advanced European Neutron Sources about how neutron science is contributing to the fight against global health threats.

Computation will also play and important role in understanding the SARS coronavirus and it is likely that those studying future viruses will benefit from quantum-computing technologies that are being developed today. In this episode we hear from Winfried Hensinger at the University of Sussex, who is cofounder of a quantum-technology start-up called Universal Quantum. The firm has just received a round of seed funding to help it achieve its ultimate goal of integrating a million ion-based quantum bits within a practical quantum computer.

Also on hand is Physics World student contributor Robin Kerr, who explains how living organisms can be integrated into solar cells. Kerr also chats about why he joined the Physics World student contributor network.

Super-resolution microscopy reveals nanoscale details of amyloid protein structures

Single-molecule localization microscopy

Researchers in the US have developed a novel optical microscopy technique that offers new insights into amyloid plaques, which are characteristic of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Better understanding of these clumped or misfolded proteins could help develop new therapies, the scientists claim.

Amyloids are insoluble, abnormal protein aggregates that have been linked to the development of various diseases, including diabetes and neurological conditions such as Alzheimer’s, Parkinson’s and Huntington’s disease. While most amyloid proteins may be non-toxic, they become problematic when they form fibrous deposits, or plaques, around cells and disrupt their normal function. In the brain, the misfolding and clumping of amyloids can kill many neurons.

Understanding the underlying structure of these plaques could pave the way for the development of effective therapeutics against these diseases. Now, researchers at Washington University in St. Louis have developed a new optical microscopy technique that measures both the location and orientation of single molecules in these amyloid protein aggregates, revealing nanoscale details about their structures.

“We need imaging technologies that can watch these molecular movements in living systems to understand the fundamental biological mechanisms of disease,” explains Matthew Lew, who led the research. “Amyloid and prion-type diseases like Alzheimer’s, Parkinson’s and diabetes are our first targets for this technology, but we see it being applied in many other areas too.”

Amyloid proteins have the ability to be stained by certain florescent dyes. And, as there is no artificial link between the fluorescent probes and amyloid surfaces, the probes’ binding orientation can potentially provide information about the structure and organization of the amyloid proteins.

The researchers created a performance metric to characterize how well various microscopy techniques measured the orientations of such fluorescent dyes. In work described in the journal Optica, they report that a microscope that splits fluorescence light into two polarization channels provides superior and practical orientation measurements.

The new super-resolution microscopy method allows them to measure not only the location of the fluorescence, but also characteristics such as polarization, which are ignored in most other microscopy approaches.

“The metric we developed calculates the performance of a particular microscope design 1000 times faster than before,” explains Tingting Wu. “By measuring the orientations of single molecules bound to amyloid aggregates, the selected microscope enabled us to map differences in amyloid structure organization that cannot be detected by standard localization microscopes.”

The researchers quantified how the orientations of fluorescent molecules (Nile red) varied each time one attached to an amyloid protein. Differences in these binding behaviours can be attributed to structure differences between amyloid aggregates. Because the method provides single-molecule information, the researchers could observe nanoscale differences between amyloid structures.

“In optical microscopy and imaging, scientists and engineers have been pushing the boundaries of imaging to be faster, probe deeper and have higher resolution,” Lew says. “Our work shows that one can shed light on fundamental processes in biology by, instead, focusing on molecular orientation, which can reveal details about the inner workings of biology that cannot be visualized by traditional microscopy.”

The researchers note that their microscopy setup used commercially available parts that are accessible to anyone performing single-molecule super-resolution microscopy. Next, they plan to monitor amyloid structures over hours and days to observe nanoscale changes as they develop and organize. Long-term studies of amyloid aggregates could reveal new information about how amyloid proteins are organized and how quickly they grow or spontaneously dissolve, the team says.

Striking with precision: how I put my planning ego aside

Want to learn more on this subject?

Elekta webinar 2020-07-16This webinar will explore the nuances of planning simple and complex Gamma Knife cases using inverse planning tools and metrics. Radiosurgical planning and pre-planning can have a significant impact on the clinical decision-making process.

Often the knowledge that one has the ability to deliver the required dose to the target while protecting critical structures can eliminate the need for an open procedure.

Optimizing both planning time and delivery time, these tools and techniques can greatly improve the patient experience. Modern inverse planning software can optimize multiple objectives at the same time making complex dose plans possible.

The webinar presented by Dheerendra Prasad will cover:

  • Identifing key treatment planning.
  • Learning how to evaluate dose.
  • Learning hybrid forward-planning and optimization.
  • An introduction to total inverse planning.

Want to learn more on this subject?

Dheerendra Prasad is director of the Gamma Knife Center and professor of oncology, neurosurgery and radiation medicine at Roswell Park Cancer Institute, Buffalo, New York, USA. He is an international expert in the field of gamma knife radiosurgery and has treated more than 10,000 patients in a career spanning more than 30 years. He has written several journal articles, books and book chapters, and contributed to many research studies in this field.

Imaginative intersection

The seemingly unconnected worlds of quantum physics and art have been linked from early in the 20th century. Part exhibition catalogue, part discourse on this relationship, Entangle: Physics and the Artistic Imagination, makes the case that imagination is critical for both practices, and both can learn from each other. The beautifully illustrated book is edited by Ariane Koek, the founder of the Arts at CERN programme and curator of the 2019 exhibition held at Bildmuseet, Umeå University, Sweden, featuring works by 14 international artists inspired by particle physics. 

In her introduction, Koek uses the quantum entanglement metaphor to throw light on the link between physics and art, saying that “What is entangled in the process of both of these different ways of knowing and looking at the world, is crucially the imagination – that mysterious process by which we make unexpected links, out-of-the-box connections, and have inexplicable intuitions beyond the known world.” The book makes the case for the importance of interactions between art and physics via a series of essays by physicists and science communicators. It also includes a number of personal discourses between artists and physicists on gravity, time, space, light, matter and entropy.

Theoretical physicist and bestselling author Carlo Rovelli, from the Aix-Marseille University, provides a short overview of quantum entanglement. Predicted by Albert Einstein and collaborators in 1935, it describes the mysterious connection that exists between remote quantum systems, so that any change made to one instantly influences the other. It is still one of the hardest parts of quantum mechanics to understand in terms of the everyday world – or as Rovelli puts it, “How the hell do the two particles make their decisions consistent? Simple answer: we have no clue.”

However much data we have, they don’t provide us with new ideas for their interpretation – that takes imagination

Science writer Philip Ball follows this with a plea for the importance of imagination in physics, quoting Einstein in 1929, saying, “Knowledge is limited. Imagination encircles the world.” Ball interprets this to mean “imagination precedes knowledge and establishes the precondition for it” and points out that however much data we may have from the Large Hadron Collider and other particle colliders, they don’t provide us with new ideas for their interpretation – that takes imagination. 

He suggests the current inability to explain dark matter, or why we haven’t been able to integrate supersymmetry into the Standard Model of particle physics, should be seen as a failure of imagination. Indeed, Ball writes that “the collective imagination of physicists has not yet made them vivid enough to be revealed or disproved”. He adds that efforts to provide a physical picture of quantum mechanics are placing more demands on physicists’ imaginations than ever before. Perhaps, he muses, inspiration may come from philosophy, art, literature or aesthetics “as imagination doesn’t recognize categories and boundaries”.

The entanglement of art and physics was, unsurprisingly, a feature of the surrealist art movement, beginning in 1917. Gavin Parkinson of the Courtauld Institute of Art, London, provides a fascinating history of this relationship, which ultimately went sour. Key surrealists such as André Breton and Salvador Dalí became intrigued by relativity in the 1920s; while in 1943, painter Max Ernst made an explicit case for a philosophical link between surrealism and quantum theory – comparing the uncertainty of quantum phenomena to that of the role of the unconscious in surrealism. But after the war, anti-nuclear sentiment led to an intense critique of physics, and by 1958 the movement thought to “expose the physicists, empty the laboratories”. Only Dalí, who had himself become estranged from the other surrealists, stayed loyal to physics.

Foreground: “Two self-revolving toruses” by Julius von Bismarck (2010/2018). Background: “Space study 1-4” by Jorinde Voigt (2016).

The final essay by Nicola Triscott, chief executive of the Foundation for Art and Creative Technology in Liverpool, UK, expands on both the culture of physics and the contribution of artistic approaches to physics. Triscott argues that the discipline still represents itself as being without culture and value-free, but she presents numerous pieces of evidence to the contrary. For example, she looks at how ideas on gender and physics change geographically, with the perception of physics as “hard science” connected with maleness being prevalent in north-western Europe but not further south and east. Triscott also discusses the contribution artists can make to science, via numerous visiting-artist programmes, and through the adoption of ways of working that would be considered outside the traditional scientific method – for example, Mark Neyrinck at the University of the Basque Country, Bilbao, who has used origami to study cosmic structures. 

The essay contributions are followed by what Koek describes as “diptychs” – short discourses from an artist and physicist pair who give personal reflections on a theme, providing contrasts and commonalities. These perspectives go a long way to show that imagination and intuition are “entangled in the process of scientific discovery, just as they are in the artistic process”.

Entangle ultimately urges us to keep examining the relationship between physics and the arts. Koek herself acknowledges that there is “no proof that these interactions have led to big discoveries – yet”, adding that “more work [is] needed to track impacts”. But she argues “the culture of physics as a whole is benefiting from interactions with artists”.

  • 2019 MIT Press, 384pp £23.25hb

The feelings you get when you discover something new

In January 1957 J Robert Oppenheimer was on holiday in the Caribbean when he received a telegram from the Nobel-prize-winning physicist Chen-Ning Yang informing him that experimentalists had discovered that parity is not conserved in the weak interaction.

“Walked through door,” Oppenheimer cabled back to Yang.

Reactions to unexpected events, whether in science or otherwise, are often loosely lumped together as instances of surprise. Philosophers, however, discern several different ways to experience the unforeseen. Oppenheimer’s reaction to what’s called “parity violation”, for instance, I’d say is an example of shock. Shock is when your trusted set of basic assumptions slams into an equally trustworthy finding.

The vast majority of physicists, it’s safe to say, experienced that emotion in January 1957. Until then, they had assumed that every process in physics remains the same if you reverse all three spatial co-ordinates, and had now learned that it wasn’t true. Yang once told me that, for physicists, the discovery of parity violation was like having the lights switched off and being left in such total confusion that you were unsure if, when the lights came back on, you’d be in the same room.

After this particular discovery, the room didn’t look too different to before. What interests me, though, is the shock – the momentary sense that foundational assumptions could be undermined. It’s a physicist’s emotional acknowledgment of the abyss.

Experiencing the unexpected

A different way to experience the unexpected is to be bewildered. Bewilderment also involves a conflict between a finding and your assumptions, but this time your gut goes with those assumptions. You strongly suspect that something’s wrong with an experiment or finding, but you aren’t entirely sure. Think of your reaction to the “discovery” of cold fusion in 1989 or faster-than-light neutrinos in 2011.

I’m aware that I’m using ordinary words such as “shock” and “bewilderment” to describe phenomena that, to philosophers like me, have particular technical characteristics. But then physicists do the same if you think of how you use terms like “friction”, “impulse” or “power”. These names might be colloquial but they’re not arbitrary, and are used because of their loose relation to their technical meaning. So pay less attention to the words I’m about to use and more to the experiences that they point to.

In an essay in the 2018 book Surprise: an Emotion?, Anthony Steinbock – a fellow philosopher at Stony Brook University – characterizes “surprise” as being attentively and expectantly attuned to something, which then catches you off-guard and throws you back on your own experience. You accept, let’s say, both the unexpected findings and the assumptions embedded in your physics practice. But in contrast to both shock and bewilderment, you presume they can nevertheless be integrated.

Surprise involves “a believing what I cannot believe”, Steinbock writes. Think of the reaction when two teams of experimental particle physicists announced, on 11 November 1974, that they’d measured a spike in the number of particles produced at energies of 3.1 GeV indicating the existence of a long-lived particle now known as the J/ψ. As the Italian physicist Giuliano Preparata wrote: “It was as if one found in some remote region of the Earth a human race whose life expectancy was not 70 but rather 70,000 years!” Yet nobody in the physics community doubted either the findings or quantum electrodynamics.

Tell me you weren’t awed last year by the first photos of a black hole, or by the 2016 data demonstrating the existence of gravitational waves

Surprise is different from “awe”, which is a deep respect for a fundamental phenomenon when it abruptly emerges strongly and directly. Tell me you weren’t awed last year by the first photos of a black hole, or by the 2016 data demonstrating the existence of gravitational waves. Neither event was a surprise or shock in the sense of challenging fundamental assumptions. You knew these things were surely there. What was unexpected was that they appeared so magnificently and so suddenly.

“Amazement”, meanwhile, is the experience of a phenomenon that puts in an unexpected appearance but then never goes away. Think of the idea that energy comes in discrete quantities. At the beginning of the 20th century, the “quantum” was regarded as a troublesome but isolated phenomenon that might eventually disappear, but which kept repeatedly turning up, like a peculiar uninvited guest who stalks you and eventually joins your inner circle of friends.

Then there’s “astonishment”, which is the experience of something that you did not believe was even possible – not in the perceptual cards, so to speak – and forces you to reconfigure your experience. In 1895, for example, when the German physicist Wilhelm Röntgen first saw his cathode-ray tube making his fluorescent screen glow, he thought he was hallucinating. Only after elaborate exploration could he believe it was real. But Röntgen remained so mystified about his observation that he called it an “X-ray”.

The critical point

Shock, bewilderment and the other reactions I’ve mentioned are a familiar part of ordinary life. So why am I bothering to point out that they’re a familiar part of physics as well? The reason is that these reactions shed light on the differences and similarities between ordinary activities and physics. For example, in physics, time is a scalar quantity – a measurable sequence of discrete moments. In ordinary life, however, we live time as a flow in which we must simultaneously anticipate and remember.

So when physicists experience surprise, it dramatizes the presence of ordinary time in their activities. You can only find something surprising in the present because you have assumptions (the past) and expec-tations (the future). At its most exciting, therefore, physics is an encounter with the potentially strange, and when the strange arrives the encounter cannot help but be emotional. 

But are these phenomena I’ve described familiar to you? If so, or if you have better names or other experiences, send them in and I’ll write about them in a future column.

Copyright © 2026 by IOP Publishing Ltd and individual contributors