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Thousands of physicists sign letter condemning ‘disgraceful’ Alessandro Strumia gender talk

More than 3000 physicists have so far signed an open statement denouncing a recent talk by theoretical physicist Alessandro Strumia of the University of Pisa. The talk was given on 28 September at an inaugural CERN workshop on high-energy theory and gender in which he claimed that men, not women, face discrimination when seeking jobs in physics. The statement, which has been signed by Nobel laureate David Gross and other prominent scientists, calls Strumia’s arguments “morally reprehensible”.

Strumia’s presentation at CERN included graphs and tables that analyse the citation records of papers written by male and female physicists. In the talk, he stated that these data show that “top authors are man, man,…man”. He also claimed that data related to academic hiring show that women with fewer citations were being hired over men with greater numbers of citations. In one slide, Strumia, who is an associate of the theory department at CERN, claims that he was passed over for a job at Italy’s National Institute for Nuclear Physics, despite having many more citations than the successful female candidate. The woman in question was in the audience at Strumia’s talk.

Belittling the ability and legitimacy of scientists of colour and white women scientists using such flimsy pretexts is disgraceful

Particles for Justice statement

Following the presentation, CERN removed a video of it from the lab’s website along with Strumia’s slides and released a statement describing it as “highly offensive”. CERN then suspended Strumia from any activity at CERN with immediate effect, pending an investigation into his presentation. “CERN, like many members of the community, considers that the presentation, with its attacks on individuals, was unacceptable in any professional context and was contrary to the CERN Code of Conduct,” a statement from the Geneva-based lab says. On 1 October the University of Pisa also opened an ethical investigation in Strumia’s behaviour.

In a statement on 3 October (and updated on 5 October), CERN director general Fabiola Gianotti and CERN theorist Gian Giudice, who co-organized the meeting, says it is “disappointing” that the workshop had been “overshadowed by one speaker who made statements contrary to the ideals on which CERN is based”. It adds that Strumia “used his presentation to make unacceptable personal allegations against individuals attending the workshop, which is why we have been obliged to take action”.

“Fundamentally unsound”

On 4 October, 18 physicists including Sean Carroll from the California Institute of Technology and Chanda Prescod-Weinstein from the University of Washington and the University of New Hampshire, published a statement noting they were “appalled” by Strumia’s actions and views on women in high-energy physics. “The thin veneer of scientific rigour with which Strumia’s talk began was followed by open discrimination and personal attacks, which we condemn unconditionally,” it says.

They point out that the science case presented by Strumia was “fundamentally unsound” adding that he misused his physics credentials to put himself forward as an expert on gender studies. “He fundamentally made the basic error of conflating correlation with causation, and while Strumia claimed to be proving that there is no discrimination against women, his arguments were rooted in a circumscribed, biased reading of the data available, to the point of promoting a perspective that is biased against women,” the statement says.

The statement then offered eight examples in his presentation where alternative conclusions could be drawn. In one of those points, the authors take aim at Strumia’s claim that since the most cited papers are disproportionately by men, this gives evidence that men are intrinsically better at physics. “In between intrinsic ability and citation counting however, there is the huge and complicated process of how physicists are raised, trained, hired, and perceived,” the statement says. “Even at the professorial level, discrimination can still play an important role.” They add that without a thorough understanding of such processes, “it is impossible to conclude anything about people’s innate abilities”.

“Belittling the ability and legitimacy of scientists of colour and white women scientists using such flimsy pretexts is disgraceful,” the statement notes. “It will add to the obstacles that women and gender minorities, as well as men from traditional underrepresented communities, struggle with on a daily basis.” The five-page statement concludes by hoping that speakers at future workshops on gender and other ascribed identities should include “recognized” experts who have a track record of speaking and publishing in such areas.

In an e-mail to Physics World, Strumia says the authors of the statement are a “US-centric small fraction of the physics community [that] defends the gender theory which is mainstream in ‘politically-correct’ academias [sic]”. He adds that the authors of the letter “don’t mention the alternative theory which I summarized because it can fit the data, which is what matters in science [rather than] claiming that deplorables should be fired.” Strumia also complains that the authors do not link to his slides and that it is “false” that he belittles the ability and legitimacy of scientists of colour.

Thirty years of the IPCC

It’s over 120 years since Swedish chemist Svante Arrhenius predicted that burning fossil fuels would enhance Earth’s natural greenhouse effect. Back then Arrhenius thought this warming might be beneficial for future generations. As time has passed it’s become clear that extra carbon dioxide is likely to cause more problems than it solves; by the 1970s concern was growing and in 1975 US-based geochemist Wallace Broecker coined the term “global warming” in his landmark paper “Climatic change: are we on the brink of a pronounced global warming?” But it wasn’t until more than a decade later that a consensus around climate change started to emerge.

The year 1988 proved to be a major turning point. NASA scientist James E Hansen testified to US Congress, reporting a clear cause and effect between excess carbon dioxide and global warming, and predicting that freak weather would be likely to increase over time. Later that same year the Intergovernmental Panel on Climate Change (IPCC) was formed to collate and assess evidence on climate change.

It has shown that human induced climate change is not an opinion but a scientific fact.

Paul Valdes

In the 30 years since the IPCC began, we’ve managed to warm our planet by a further 0.5 °C. Global mean temperatures are now 1 °C warmer than in pre-industrial times, and the rate of warming doubled over the course of the 20th century. A total of 16 of the 17 warmest years on record have occurred since 2000. The statistics are alarming and warming continues apace. So what impact has the IPCC had over its lifetime, and what role should the organization play in the future?

Scientific remit

When first established by the World Meteorological Organization (WMO) and the United Nations Environment Program in 1988, the IPCC’s remit was to provide the world with a clear scientific view on the current state of knowledge in climate change, and the potential environmental and socioeconomic impacts. In this respect the organisation has clearly been successful.

“It has allowed Earth-system scientists to come together in a never-before seen way, to address our current understanding of climate change, its impacts and mitigation strategies,” says Dann Mitchell, climate scientist at the University of Bristol, UK, and contributor to the forthcoming IPCC Special Report on Global Warming of 1.5 °C (SR15). Mitchell’s colleague at the University of Bristol, Paul Valdes, whose work has also been part of IPCC reports, concurs. “Its key achievement has to be showing clear scientific certainty around climate change,” he says. “It has shown that human induced climate change is not an opinion but a scientific fact.”

Any country that’s a member of the United Nations Environment Program or WMO is eligible to join the IPCC; currently 195 countries are members. Crucially, the IPCC does not conduct any research of its own, or monitor climate. Instead the body reviews and assesses the most recent scientific, technical and socioeconomic information. The organization is divided into three Working Groups and a Task Force on Greenhouse Gas Inventories. Working Group I deals with “The Physical Science Basis of Climate Change”, Working Group II with “Climate Change Impacts, Adaptation and Vulnerability”, and Working Group III with “Mitigation of Climate Change”. Meanwhile, the Task Force develops and refines methods for calculating and reporting on national greenhouse gas emissions and removals.

I’m motivated to do this work because it is an amazing experience to meet and work with incredible scientists from around the world, and because I can provide something unique and important to help the world take action on climate change.

Kristie Ebi

It’s a huge undertaking. Thousands of scientists from around the world contribute their expertise and knowledge, all at no cost. Meanwhile, governments participate in the review process and are asked to accept, adopt and approve reports.

“Because scientists are not paid they are able to represent their science and not be bound by their institution, organisation or government, but it is an immense amount of work – up to six months for authors – that often isn’t recognised by universities when considering promotions,” says Kristie Ebi, director of the Center for Health and Global Environment at the University of Washington, US. “I’m motivated to do this work because it is an amazing experience to meet and work with incredible scientists from around the world, and because I can provide something unique and important to help the world take action on climate change.”

Regular tasks

The IPCC’s main output is regular Assessment Reports: chunky volumes that summarize the current state of knowledge. The most recent is the Fifth Assessment Report, published in 2013/14. Its four volumes – on the Physical Science Basis; Impacts, Adaptation and Vulnerability; Mitigation of Climate Change; and the Synthesis Report – were commissioned back in 2008, and represent six years of data assimilation, peer review and rigorous debate.

The next IPCC report is well under way but won’t be published until 2022; gathering and assessing the data is an immense task. “There is a need to find ways to ensure a comprehensive assessment is carried out, as required by the IPCC, within the context of a vastly expanding literature base,” says Ebi, who was previously executive director of the Working Group II technical support unit, and was involved in updating IPCC rules and procedures following a review of the process. “It is a mammoth effort for a group of volunteers, and we have to accept that producing a report of this quality takes time.” But Valdes believes it could be streamlined further. “The current format of the IPCC is too cumbersome and needs to change radically,” he says. “I think it should make a short report, every two to three years, which focuses on the major updates to the science.”

To date, the ripple from each report has had a significant impact on our understanding and perceptions of climate change. The evidence published in the first IPCC Assessment Report in 1990 underlined the importance of international co-operation to tackle the consequences of climate change, and is credited with triggering the formation of the United Nations Framework Convention on Climate Change (UNFCCC), an international treaty to reduce global warming and cope with the consequences of climate change. The Second Assessment Report of 1995 concluded that the balance of evidence suggests “a discernable human influence” on Earth’s climate, and strongly influenced negotiators in their decision to adopt the Kyoto Protocol extension to the UNFCCC in 1997, with developed nations pledging to reduce emissions by an average of 5% by 2008–12. In 2007 the IPCC was recognized for its work, when together with former US vice president Al Gore the organisation won the Nobel Peace Prize, for “their efforts to build up and disseminate greater knowledge about man-made climate change, and to lay the foundations for the measures that are needed to counteract such change”.

The current format of the IPCC is too cumbersome and needs to change radically… it should make a short report, every two to three years, which focuses on the major updates to the science

Paul Valdes

However, it hasn’t all been plain sailing. Disagreements have flared up over perceptions of scientists using their IPCC credentials to push their own agendas and potentially politicize the science. Meanwhile the 4th Assessment Report, published in 2007, resulted in scandal when a paragraph that projected Himalayan glaciers to disappear by 2035 was found to be incorrect, and the IPCC was hauled over the coals for its use of non-peer reviewed material.

But in the main such problems have been rare, and around the world the findings of the IPCC are held in high regard. “Nowadays, most well-informed unbiased individuals simply accept human-induced climate change based on the overwhelming scientific consensus,” says Mitchell.

Where next?

Which does beg the question “what more can the IPCC do?” Valdes believes that climate science is reaching a similar state of knowledge to that of medical science in the 1970s and 80s, when the link between smoking and health was proven. As a result, he isn’t convinced that climate scientists and the IPCC can do much more to reign in global warming. “I would strongly argue that the barriers for progress are no longer scientific,” he says. “The politically orientated ‘climate sceptics’ will never listen to the science. There will never be a moment when everyone agrees and thus more and better science will, sadly, not help.” Valdes adds that the major job has been done and although there remains a lot of detail to clarify, little of it will alter policy. “Indeed with my palaeoclimate perspective, I think there may well be a limit on the skill of climate predictions,” he says. “At short spatial and temporal scales, climate is chaotic, just like weather, and hence better models will never be able to give precise regional details for 2030, for example.”

That said, climate models can give reliable detail at the country and continent scale, and it is here that Mitchell thinks the IPCC should focus next. “Future IPCC reports could review country-level scientific analyses so that local governments can be better informed,” he says. Meanwhile, Ebi believes there is still much work to be done in understanding the impacts of climate change and assessing adaptation and mitigation strategies. “Most modelling focuses on the physical parameters, but now we need to look at development choices and how they affect vulnerabilities,” she explains. “And we need to investigate the co-benefits of mitigation strategies: often the health benefits of a particular mitigation will pay for the policy.”

Without a doubt the IPCC has helped move the conversation from questioning whether manmade climate change is real, to asking what we can do to prepare and manage the worst consequences. Indeed, those consequences form the basis for much of the science being done now. Currently IPCC scientists are trying to answer the question of what 1.5 °C warming will look and feel like, and what we need to do to keep global warming within these limits. Their Special Report on Global Warming of 1.5 °C, published in October 2018, is in response to the agreement signed at the UNFCCC’s meeting in Paris in 2015. Right now, the stakes couldn’t be higher, and our actions over the coming years will determine what kind of climate Earth has for aeons to come.

The IPCC Special Report on Global Warming of 1.5 °C: the why, the what and the how

Will a world that’s 1.5 °C warmer experience more hurricanes and typhoons? How much will mountain glaciers retreat? Which regions will suffer more frequent drought and crop failure? Not only are there questions about what this level of temperature rise will look like but also what we’d have to do to limit warming to this amount, and whether it’s worth pulling out all the stops to do so.

In October 2018 the Intergovernmental Panel on Climate Change (IPCC) releases its Special Report on Global Warming of 1.5 °C (SR15). The need for this report arose from the Paris Agreement of December 2015, when the 195 members of the United Nations Framework Convention on Climate Change (UNFCCC) agreed to try to limit the temperature increase to well below 2 °C above pre-industrial levels and, crucially, to aim for a 1.5 °C rise at most. Before the Paris meeting, much of the focus had been on examining how much warming might occur by a particular time; 2050, 2080 or 2100, say. “The Paris Agreement made the scientific community reframe the questions they ask, to examine what could the world be like when it reaches a particular temperature,” says Kristie Ebi from the University of Washington, US, who’s a lead author on the 1.5 °C report.

There’s been extensive research investigating the impact of 2 °C of warming, but 1.5 °C hadn’t been looked at in detail. “The 1.5 °C global warming target caught many scientists off guard,” says Dann Mitchell, a climate scientist at the University of Bristol, UK, who also contributed to the 1.5 °C report. “We had performed lots of analysis for climate impacts at higher temperature limits, but not this limit.”

We needed to ask ‘are impacts in societally relevant sectors detectable between the two temperature limits?’ And given the answer to that, are the costs of limiting global warming to 1.5 °C justified?

Dann Mitchell

Over the last two years, scientists have worked frantically to estimate the impacts of 1.5 °C of warming and publish their findings in peer-reviewed journals. The SR15 authors have had to assess this body of research and compose an accurate, comprehensive and objective report. Three major questions loomed large. “Given the political willpower needed, and the considerable cost of stabilizing climate at the lower limit, the report needed to ask whether 1.5 °C was even possible given how much carbon we have already emitted into the atmosphere?” explains Mitchell. “Also we needed to ask ‘are impacts in societally-relevant sectors detectable between the two temperature limits?’ And given the answer to that, are the costs of limiting global warming to 1.5 °C justified?”

Fine-scale findings

Here it is the detail that is important: whether floods in Bangladesh will be significantly worse with 2 °C warming than 1.5 °C; whether wildfire risk in California will be amplified by the extra half degree of temperature rise; and whether tropical storms will cause noticeably more damage at the 2 °C threshold than at 1.5 °C.

One such question was how much European summers are likely to change. To answer it, Laura Suarez of the Max Planck Institute for Meteorology, Germany, and her colleagues used a coupled climate model to simulate the evolution of the Earth’s climate under 1.5 °C and 2 °C conditions. “The ‘Grand Ensemble’ features a hundred potential Earths, and produces a hundred potential futures to robustly sample the influence of internal variability in the chaotic climate system,” says Suarez.

The Paris Agreement made the scientific community reframe the questions they ask

Kristie Ebi

The researchers found that, because of that large degree of internal variability, the difference between 1.5  °C and 2 °C of warming was not as great as you might expect, with only 10% of the warmest European summers avoided by keeping within the 1.5 °C limit. But that small difference could still be worth achieving. “These events would correspond to the most extreme and severe heat waves, the ones with the most critical consequences,” says Suarez. The team published their findings in Environmental Research Letters (ERL).

What’s more, Suarez and her colleagues showed that the differences between extreme summer temperatures are not evenly distributed across the continent. For moderately extreme events – the kind of heatwave experienced once in every 20 years –Southern Europe was the most vulnerable, but for once in a century heatwaves Central Europe was most at risk. “All in all, at 2 °C of warming, extreme events will become warmer in Southern and Eastern Europe; around 1.5 °C warmer than at 1.5 °C of global warming,” says Suarez. “Also, at 2 °C of warming there is an increased probability of very extreme events over countries like France, Germany and Poland, and these extremes could be up to 3 °C warmer than at 1.5 °C of warming.”

Sustainable development

As well as understanding what 1.5 °C of warming will feel like, the report explicitly assesses climate change mitigation and adaptation in the context of sustainable development. “My hope would be that this report can provide insights into how one can work towards achieving the full set of sustainability objectives that governments identified in 2015, including climate change protection,” says Joeri Rogelj of the International Institute for Applied Systems Analysis in Austria and Imperial College London, who co-ordinated one of the 1.5 °C report’s chapters. In particular, the report examines the complex interactions that occur when adaptation and mitigation measures are put in place, and the trade-offs associated with some decisions. “When we work out the cost of mitigation policies we also need to look at the co-benefits,” explains Ebi. “For example, the health benefits of a particular mitigation policy will often pay for the policy.”

Preliminary findings certainly indicate that there are substantial economic benefits associated with meeting the 1.5 °C target. In a paper published in Nature in May 2018, Marshall Burke from Stanford University, US, and his colleagues, calculated that meeting the 1.5 °C target by the end of this century, instead of the more common 2 °C goal, would save the world $20 trillion.

Nonetheless, many scientists are sceptical that the 1.5 °C goal can be met. “I have to confess that I am doubtful that we can achieve this target, but I do believe that we may be in reach of 2 °C, albeit with a bit more luck and a huge amount more effort,” says Paul Valdes from the University of Bristol, UK. In particular, countries like China give Valdes optimism. “Although the pollution and emissions are high, China is clearly showing major commitments to change.”

But Valdes also cautions against being too fixated on the temperature targets themselves. “Sometimes I fear that these targets are seen as scientific absolutes,” he says. “For example, believing that if global temperatures exceed 2 °C, then we have ‘dangerous’ climate change, but that less than 2 °C will be okay; the reality is that there is no scientific definition of ‘dangerous’ climate change and, as far as we are aware, there is no sudden threshold. The impacts of climate change will become more and more serious as temperatures rise, but there is no sudden universal change at 1.5 or 2 °C.”

The most recent studies indicate that even if we do manage to keep a lid on rising temperatures, some key parts of the Earth system might be more sensitive to warming than previously thought. “Recent literature has consistently revised estimates to imply stronger and faster impacts with ice-sheet loss and sea-level rise,” says Rogelj.

However, relative to the “business as usual” scenario of 4 °C of warming, 2 °C will significantly reduce the high risks associated with climate change. The 2 °C limit has been chosen with care. As the recent UNFCCC Structured Expert Dialogue puts it, “2 °C of warming is better seen as an upper limit, a defence line that needs to be stringently defended, while less warming would be preferable”.

All these factors must be weighed up when deciding which path of action to take. Carbon removal or geoengineering might be ways forward, or maybe we need to accept that we will overshoot the 1.5 °C target but make plans to ramp the temperature back down as soon as possible. Once they’ve read the report, policymakers and governments have some hard thinking to do.

1.5 °C warming limit needs ‘unprecedented changes in all aspects of society’

Limiting global warming to 1.5 °C would require rapid, far-reaching and unprecedented changes in all aspects of society, according to a special report from the Intergovernmental Panel on Climate Change (IPCC). But, compared to a 2 °C temperature rise, the benefits to people and natural ecosystems are clear.

“Every extra bit of warming matters, especially since warming of 1.5 °C or higher increases the risk associated with long-lasting or irreversible changes, such as the loss of some ecosystems,” said Hans-Otto Pörtner, co-chair of IPCC Working Group II.

The report highlights climate change impacts that could be avoided by limiting global warming to 1.5 °C. For example, by 2100, global sea level rise would be 10 cm lower with global warming of 1.5 °C compared with 2 °C. The likelihood of an Arctic Ocean free of sea ice in summer would be once per century, compared with at least once per decade with 2 °C. And coral reefs would decline by 70–90%, whereas virtually all (> 99%) would be lost with 2 °C.

The report also examines pathways to achieving a 1.5 °C limit on global average temperature rise. This, it finds, would require “rapid and far-reaching” transitions in land, energy, industry, buildings, transport, and cities. Global net human-caused emissions of carbon dioxide would need to fall by about 45% from 2010 levels by 2030, and reach “net zero” around 2050, with any remaining emissions balanced by removing carbon dioxide from the air.

“The good news is that some of the kinds of actions that would be needed to limit global warming to 1.5 °C are already under way around the world, but they would need to accelerate,” said Valerie Masson-Delmotte, co-chair of Working Group I.

Allowing the global temperature to overshoot 1.5 °C would mean a greater reliance on techniques that remove carbon dioxide from the air to return temperatures below this limit by 2100. The effectiveness of such techniques are unproven at large scale and some may carry significant risks for sustainable development, the report notes.

“Limiting global warming to 1.5 °C compared with 2 °C would reduce challenging impacts on ecosystems, human health and well-being, making it easier to achieve the United Nations Sustainable Development Goals,” said Priyardarshi Shukla, co-chair of IPCC Working Group III.

The decisions we make today are critical in ensuring a safe and sustainable world for everyone, both now and in the future, according to Debra Roberts, co-chair of IPCC Working Group II. “This report gives policymakers and practitioners the information they need to make decisions that tackle climate change while considering local context and people’s needs,” Roberts said. “The next few years are probably the most important in our history”.

The IPCC approved the summary for policymakers of the IPCC Special Report on Global Warming of 1.5 °C on 6 October in Incheon, Republic of Korea.

A total of 91 authors and review editors from 40 countries prepared the IPCC special report following an invitation from the United Nations Framework Convention on Climate Change (UNFCCC) when it adopted the Paris Agreement, which aims to strength the global response to the threat of climate change by “holding the increase in the global average temperature to well below 2 °C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5 °C above pre-industrial levels”. Governments will review the 2015 Paris Agreement on climate change in Katowice, Poland in December.

The special report’s full name is Global Warming of 1.5 °C, an IPCC special report on the impacts of global warming of 1.5 °C above pre-industrial levels and related global greenhouse gas emission pathways, in the context of strengthening the global response to the threat of climate change, sustainable development, and efforts to eradicate poverty.

Next year the IPCC will release special reports on the ocean and cryosphere in a changing climate, and climate change and land use. The body’s sixth assessment report on climate change will follow in 2021/22.

  • This news story is based on a press release from the IPCC.

Drug-based approach sensitizes hypoxic tumours to radiation therapy

The approved drug papaverine can be used to increase oxygen levels in mouse tumour models — making them more sensitive to radiation therapy and paving the way for similar breakthroughs in human patients, according to a recently published paper (PNAS 10.1073/pnas.1808945115). So, why exactly is such a drug needed? And what were the team’s key findings?

Combating hypoxia

Human tumours often have regions of low oxygen levels (known as hypoxia) because the poorly formed blood vessels cannot deliver enough oxygen to meet the metabolic need of the tumour cells. This is problematic in a clinical setting because it has been known for decades that hypoxia makes cells more resistant to killing by ionizing radiation.

The authors of the paper point out that many strategies have been tried to deliver more oxygen to tumours to make them sensitive to radiation, but that clinical results to date have been disappointing.

In an effort to remedy this situation, Nicholas Denko from the James Cancer Hospital and the Solove Research Institute at The Ohio State University, explains that he and his team screened for drugs that could reduce oxygen consumption in vitro using Seahorse XF technology. They identified a 150 year old drug, known as papaverine or PPV, that had an unrecognized capability to perform this activity.

Papaverine rapidly reduces oxygen consumption in cells by reducing mitochondrial function, the major sink for oxygen in the cell. In order to determine the drugs’ efficacy in model tumours, the team used near infrared spectroscopy to demonstrate that papaverine increased oxygenation in tumours grown in mice within 30–40 min.

“We then tested this drug for efficacy in enhancing radiotherapy in these tumours,” says Denko. “If we give the drug first and radiation thirty minutes later, we see an enhanced effect of the radiation. If we give the drug after radiation, there is no effect, indicating that the drug does something to the tumour to make it more sensitive, which is reducing hypoxia.”

The effect of the drug with radiation resulted in about twice the effect of radiation alone, using the standard tumour regrowth assay. “We used genetics to determine that it really is the effect of the drug on mitochondria that is important,” Denko adds. “We also made derivatives of papaverine that removed its old activity and retained its mitochondrial activity. These new molecules radiosensitize like papaverine, but they may have fewer side effects.”

Approved drug

According to Denko, the new approach could be particularly helpful since, at many tumour sites, the amount of radiation that can be delivered is limited because of the risk of toxicity in nearby normal organs.

“What we are doing is effectively increasing the biologically effective dose to the tumour without increasing the dose to the well oxygenated normal tissue. This should in theory increase tumour cell kill and reduce the likelihood of tumour recurrence,” he explains.

In view of the fact that papaverine is an FDA-approved drug, Denko reports that it can be “rapidly moved into human clinical trials” — and reveals that he and his team have recently received funding to test the safety of adding the drug to radiation therapy for lung cancers. Although radiation therapy can be highly effective for treating some lung cancers, the fact that some tumours are located close to other important organs or blood vessels, means they cannot tolerate the full radiation dose.

“These tumours get a lower dose of radiation, and the fraction of tumours that are controlled is lower. We think that adding a radiosensitizer to this patient population would offer a significant benefit,” says Denko.

Moving forward, Denko predicts that the greatest challenge lies in clinically identifying those patients with very hypoxic — and therefore radioresistant — tumours, that will presumably get the most benefit from adding papaverine.

“In order to try to identify such patients, we have incorporated two strategies in our upcoming clinical trial: blood oxygen level dependent (BOLD) MRI imaging of tumours, and identification of microRNAs from the patient serum that may indicate a hypoxic tumour,” he adds.

The physics of Chewbacca, synthetic diamonds for Blue Peter, the entropy of art

I haven’t kept up with the recent Star Wars films, so I didn’t know that trains existed long ago in a galaxy far away. But it turns out that a scene in Solo: A Star Star Wars Story involving Han Solo saving Chewbacca from falling from a speeding train has annoyed some physicists (it appears at two minutes in the above trailer). Rhett Allain investigates complete with free-body diagrams in “The physics of Chewbacca falling out of a moving train”.

What would you do if you had digital images of 140,000 paintings spanning nearly a millennium of history? Being physicists, Higor Sigaki and Haroldo Ribeiro of the Universidade Estadual de Maringá in Brazil and Matjaž Perc of University of Maribor in Slovenia worked-out the entropy and complexity of the paintings. They showed that trends in these parameters are in line with the historical classification of artistic styles. So which period had peak entropy? You’ll have to read “History of art paintings through the lens of entropy and complexity” to find out.

Many readers in the UK will look back fondly on earning their Blue Peter badges – which are issued by the BBC television programme of the same name. This year is 60th (diamond) anniversary of the show, and a special diamond version of the badge has been created by the British designer Henry Holland. Not to be outdone, the company Element Six has unveiled a custom-made synthetic diamond Blue Peter badge that comprises 6.6 carats of polycrystalline diamond made by chemical vapour deposition.

Reflectance spectroscopy looks at the dark side of meteorites

An instrument that can make spectroscopic measurements of tiny amounts of light reflected by extremely dark materials such as meteorites and Vantablack has been unveiled by Sandra Potin and colleagues at University Grenoble Alpes. The instrument operates across a wide range of wavelengths, temperatures and incident angles and could provide important new information about interplanetary objects.

Reflectance spectroscopy is a useful technique for studying the composition and structure of meteorites. A sample is illuminated with narrow beams of visible and infrared light and the spectrum of the reflected light is analysed for absorption lines that reveal the chemical composition of the object.

Meteorites are often extremely dark, however, and this can make it difficult to collect enough light to create accurate spectra. Other complications include the fact that the reflectance of an object can depend strongly on its shape, which means that the measured spectrum can be different at different illumination angles. Also, the measured spectrum is dependent on the temperature of the object. This can make it difficult to compare spectra taken on Earth to spectra taken from objects in space – where temperatures can vary from very cold to very hot.

Pulsed monochromatic light

To address these problems, Potin’s team developed a new instrument called SHADOWS that operates by shining a monochromatic, 5.2 mm-diameter pulsed beam at the sample surface. Visible and infrared detectors then pick up the reflected beam; measuring both the reflectance and the absorption spectra of the sample. A spectrum is obtained by changing the wavelength of the incident light. The azimuthal and elevation angles of the incident beam can also be changed during the measurement, allowing researchers to build up a detailed 3D angular map of the sample’s reflected light.

The detectors are synchronized to the light pulses using a technique called lock-in amplification, which greatly reduces the noise in the spectra.

The team showed that SHADOWS can operate over a wide spectral range of 350–5000 nm, and at sample temperatures of –20 °C to 250 °C. To show that the instrument is effective for extremely dark samples, the team obtained angle-dependent spectra for Vantablack – the darkest synthetic substance ever created. This showed that SHADOWS can study materials that reflect as little as 0.035% of incident light.

Potin say that the directional nature of the instrument could reveal important new structural information from samples that is not currently accessible by other techniques. The team is now making improvements  to SHADOWS that include the ability to measure shifts in polarization of the reflected light.

SHADOWS is described in Applied Optics.

DNA molecules help make reconfiguring ‘colloidomers’

Researchers have succeeded in self-assembling polymers that are a thousand times bigger than molecular polymers, but which still follow the same laws of statistical physics. Unlike molecular polymers, however, these colloidomers, as they are called, are reconfigurable because the monomers that make them up are linked together via DNA molecules. The freely-jointed colloidal system, which is an example of self-assembly on the length scale that biological life assembles itself, might be used to make materials that continuously reassemble into new structures in response to a predefined trigger, such as a temperature change.

Designing materials that can be preprogramed to reconfigure themselves into new structures is one of the important goals of modern polymer science. A team of physicists and mathematicians led by Jasna Brujic of New York University has now taken an important step forward in this direction by making reconfigurable, freely-jointed linear and branched colloidomer chains from micron-sized droplets of PDMS (suspended in water) linked together with DNA molecules. The chains can be repeatedly dismantled and rebuilt by simply heating them up and cooling them down.

“Each droplet-droplet bond contains a few thousand links,” explains Brujic, “so controlling the number of DNA molecules governs the number of bonds the droplets can make.” When the system is heated, the DNA melts and the chains dismantle. The structures then spontaneously reassemble once they have cooled down again.

The researchers say they have succeeded in fabricating more than 22,000 colloidomers using their technique. The colloidomer chains are between 2 and 20 droplets long.

“Extremely floppy”

“These polymers are extremely floppy on the level of single droplets,” Brujic tells Physics World. “We followed their configurations in space and time and found that all chain configurations are equally likely to form – there are no preferred angles. This is why we call them freely-jointed.”

“This behaviour is very much like that of molecular polymers but unlike these, the colloidomers can be repeatedly assembled and disassembled under temperature cycling, allowing for reconfigurable, responsive matter.”

Such reconfigurable polymers could be useful for making amorphous materials with switchable viscoelastic properties, for example, says Brujic. “If you could control the valence of the constituent molecules to make four bonds for every droplet, for instance, and you allowed the resulting emulsion to crystallize, you might be able to make a ‘mayonnaise-like’ diamond lattice, which would be exciting. What is more, since these droplets are similar in size to the wavelength of light, such a ‘soft diamond’ could have novel optical properties too.”

The team, which includes researchers from the Physics Department and the Courant Institute of Mathematical Sciences at NYU and the Department of Phyics at Sapienza Universita’ di Roma, says that it would now like to apply its technique to proteins.

“We would also like to provide the colloidomers with different flavours of DNA along the chain, which will allow them to fold into predesigned structures,” says Brujic. “Such a system would open the way to programmable design.”

The freely jointed polymers and their behaviour are detailed in Physical Review Letters 10.1103/PhysRevLett.121.138002.

Xinchou Lou describes working in China

In this video interview, Xinchou Lou describes his experiences working at Beijing’s Institute of High Energy Physics (IHEP). Lou is IHEP’s director of the experimental physics diivision and is also the project director on the circular electron–positron collider (CEPC) – an ambitious Chinese project to build a 100 km collider referred to as a “Higgs factory”.

Lou himself is testimony to China’s burgeoning scientific strength. He left China in 1984 for the West and – after spells in California, New York and CERN – settled at the University of Texas, where he remained for almost two decades before returning home in 2012. He was tempted back by the country’s “Thousand Talents” plan, which seeks to deepen the country’s scientific base by encouraging overseas scientists (both Chinese and non-Chinese) relocate to China.

In the interview, Lou explains why he returned to China and why he is excited about the future of particle physics. Find out more about the CEPC project in the 2018 Physics World Special Report on China. That free-to-read report examines China’s unabating rise as a scientific powerhouse, but also the challenges its facing in attracting foreign-born researchers to make a permanent move to China.

Ultrasound tool can detect high brain pressure at the scene of an accident

Elevated intracranial pressure following an accident can lead to brain injury and spinal cord damage. Currently, such pressure increases are detected using a sensor that’s surgically inserted into the patient’s skull in an operating theatre. A new tool offers the potential to perform diagnostic tests at the scene of the accident, using non-invasive ultrasound eye examinations to detect elevations in intracranial pressure.

The tool was developed by researchers at SINTEF, in collaboration with paediatric neurosurgeon Llewellyn Padayachy from the University of Cape Town and Red Cross War Memorial Children’s Hospital. The project was launched by a study involving 16 paediatric patients in South Africa: eight who suffered from elevated cranial pressure and eight with normal levels. “We obtained good results with high levels of clinical accuracy, and using these were able to further develop the technology,” says SINTEF researcher Reidar Brekken.

The research group in Cape Town has now completed a new study of 28 patients, in which the ultrasound data were analysed using software developed by the SINTEF team. This study included children undergoing invasive intracranial pressure measurement as part of their clinical management. Prior to these measurements, the researchers acquired ultrasound images of the optic nerve sheath and processed them to obtain the deformability index (DI), a parameter quantifying the pulsatile nature of the optic nerve sheath.

Results showed that the DI was significantly lower for patients with high versus normal intracranial pressure. A DI cut-off value of 0.185 of below demonstrated 89.5% sensitivity and 88.9% specificity. Combining the DI with measurement of optic nerve sheath diameter (ONSD) improved the sensitivity to 94.7%. The team also saw improved correlation with intracranial pressure measurements when using a combined analysis of DI and ONSD (Operative Neurosurgery 10.1093/ons/opy231).

The first version of the ultrasound device was manually-operated and demanded high levels of specialist expertise. Now, the team has incorporated artificial intelligence into the technology to make it more user-friendly. This will enable many more people to operate the tool and enable intracranial pressure measurements to be carried out at an earlier stage — allowing ambulance personnel to perform examinations at accident scenes, for example.

“For the most part, artificial intelligence assists by automating the measurement process,” explains Brekken. “Whereas previously we had to input data manually and identify structures displayed on the resulting image, our aim now is that the only thing an operator has to do is place the ultrasound probe on the patient’s eye. The machine will then identify the structures and deliver the measurement results.”

Brekken emphasizes that performing clinical assessments at accident scenes will make a significant difference to the patient. “It will help to save lives and prevent potential brain damage,” he says. “It will also be less expensive to implement because there will be no need to transport patients for costly surgical interventions in operating theatres in order to perform an examination.”

The team now intends to further advance and quality assure the technology, as well as develop the artificial intelligence component into a diagnostics tool. Immediate plans include testing the device on 200 patients suffering from head injuries, in collaboration with neurosurgeon Eirik Helseth at the Ullevål University Hospital. This will be the first time that the technology will be tested on adults.

The researchers are also looking into ways to exploit this technology beyond the examination of head injuries. “It isn’t just traumas such as blows to the head that cause elevations in intracranial pressure,” says Brekken. “Other neurological conditions, such as brain tumours and haemorrhaging can also result in pressure increases.”

The device is currently being commercialized by the company NiSonic.

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