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Time crystals enter the real world of condensed matter

Look at a computer processor or a superconducting device and imagine what’s inside – countless electrons flying between the ions that form a solid-state crystal. Now try to imagine it’s all happening not in space but in the fourth dimension of time. Is it possible that condensed-matter devices and conventional electronics can enter the time dimension?

In 2012 the Nobel-prize-winning physicist Frank Wilczek published his seminal article on “quantum time crystals”, in which he posed the provocative question of whether time-translational symmetry – where one instant in time is equivalent to any other – can be spontaneously broken in the lowest-energy state of a quantum-mechanical system (Phys. Rev. Lett. 109 160401). Such symmetry breaking would lead to the spontaneous emergence of a “time crystal”, just as spontaneous translational symmetry-breaking leads to the formation of an ordinary crystal in space (see “In search of time crystals” by Philip Ball, July 2018),

It was a weird idea, and almost no-one understood it. Indeed, the suggested model turned out to be wrong. That’s because in the thermodynamic limit of a large number of particles, in order to minimize energy, quantum particles prefer to stop, rather than to move, even in the presence of a magnetic field (Phys. Rev. Lett. 111 070402, Phys. Rev. Lett. 119 250602). So it’s not easy to see how particles can spontaneously exhibit periodic motion in time by a self-organization process, like they do in space, while they remain at equilibrium, in the state with the lowest possible energy (Phys. Rev. Lett. 114 251603, Phys. Rev. Lett. 123 210602).

The rise of discrete time crystals

Wilczek’s idea did, however, trigger new thinking about whether there might be other ways that crystalline behaviour could be hosted in the time dimension. In 2015 one of us (Sacha) proposed that a periodically driven (and thus non-equilibrium) quantum many-body system – such as a Bose–Einstein condensate (BEC) of ultracold atoms bouncing on an oscillating atom mirror (figure 1) – can spontaneously break discrete time-translational symmetry, due to interactions between the particles. The atoms would start to evolve with a period twice as long as the period of the driving force, to create what is known as a “discrete” time crystal (Phys. Rev. A 91 033617). Classically, such “period-doubling” of a driven oscillatory system is well known. However, in the quantum world, stationary solutions of the Schrödinger equation must follow the period of the force. If a system spontaneously chooses stationary motion with a different period, the discrete time-translational symmetry is broken. We call the symmetry discrete because not every point in time is equivalent to any other for the periodically changing force. The only points that are equivalent are those that correspond to a discrete jump in time by the period of the force.

1 Bouncing on mirrors

Oscillating atom mirror Bouncing ultracold atoms on an oscillating atom mirror (with period T = 2π/ω) is one way of producing a discrete time crystal. The atom mirror could be, for example, a blue-detuned repulsive light sheet (adapted from original figure by Artur Miroszewski).

Similar ideas were later proposed that involve periodically driven systems of spins, by teams at Princeton University in the US and the Max Planck Institute for Physics of Complex Systems in Germany (Phys. Rev. Lett. 116 250401), and the University of California, Santa Barbara (Phys. Rev. Lett. 117 090402) and Berkeley (Phys. Rev. Lett. 118 030401). These proposals considered a 1D chain of spins – such as a string of ions in electromagnetic traps – which are first prepared in a polarized spin state. The ions are then subjected to a periodic spin-flip driving pulse in the presence of spin–spin interaction and controlled spin disorder, which induces a quantum effect that prevents the system of spins from absorbing energy and heating up. Despite the fact that the driving pulses dictate a certain period, the spin system self-organizes its motion with a period twice as long as the drive. Discrete time crystals break “ergodicity”, according to which a generic periodically driven many-body system should heat up to an infinite temperature. In the proposed spin system, disorder in the presence of particle interaction is expected to be responsible for many-body localization effects, which prevent heat from being freely redistributed and account for the lack of heating.

Within a few months of these initial proposals, preliminary experimental evidence for such discrete time crystals in spin systems was reported by Chris Monroe’s group at the University of Maryland in the US, using a 1D chain of interacting ytterbium-171 ions (Nature 543 217), and by Mikhail Lukin’s group at Harvard University, using 3D ensembles of interacting nitrogen-vacancy spin centres in diamond (Nature 543 221). Similar observations have since been made in NMR experiments by Ganesh Sreejith and colleagues at the Indian Institute of Science Education and Research in Pune, using nuclear spins in organic molecules in solution (Phys. Rev. Lett. 120 180602), and by Sean Barrett and colleagues at Yale University in the US, using phosphorus-31 spins in ordered crystals of ammonium dihydrogen phosphate (Phys. Rev. Lett. 120 180603). In a different kind of system, Peter van der Straten and co-workers at Utrecht University in the Netherlands created a “space–time crystal”, with periodic structure in both space and time (Phys. Rev. Lett. 121 185301). In this experiment a BEC of ultracold sodium-23 atoms was prepared in an elongated trap, and the vibrational motion of the condensate along the radial direction – induced by suddenly changing the radial trap frequency – acted as a driving force. Again, time-periodic oscillations of the atomic density along the longitudinal direction were observed with a period twice the length of the period of the driving force. The atomic density also revealed a spatial periodic structure in the longitudinal direction; in other words, it was a crystal in both space and time.

Ultracold atoms bouncing on an oscillating mirror seem to be much more flexible for realizing discrete time crystals than spin systems do. They could let us create discrete time crystals with dramatic breaking of time-translational symmetry; for example, they can evolve with periods more than an order of magnitude longer than the driving period (Phys. Rev. A 98 013613), thereby creating lots of available “lattice sites” in the time dimension.

Time vs space

Discrete time crystals demonstrate a very important property of solid-state systems: the formation of periodic structures due to spontaneous breaking of translational symmetries. Space crystals can possess a variety of very different and useful properties: they can be insulators, conductors and even superconductors. Can we realize the equivalent of such phenomena in the time dimension?

Take a space crystal that is not perfect because the position of the ions is somewhat random or disordered. If the disorder is sufficiently strong, the electrons can’t form an electric current due to destructive interference between different scattering paths. Instead, they become localized and unable to propagate in space in a way predicted by the physicist Philip Anderson in 1958. But such “Anderson localization” can occur in the time dimension too. To understand why, imagine bouncing a ping-pong ball on a bat. If we were a bad table-tennis player, we’d probably lose the ball because our hand is shaking randomly. However, if the ball were a quantum object – like a BEC of ultracold atoms – quantum mechanics would help us, because the time disorder from our shaking hand would result in Anderson localization in the time dimension (Sci. Reports 5 10787). This is an example of a condensed-matter phenomenon that can be observed in the time dimension when a space crystal is exchanged with a time crystal and disorder in space is substituted by disorder in time (figure 2).

2 Anderson localization

Anderson localizationComparison of the well-known phenomenon of Anderson localization in a 1D space crystal having periodic boundary conditions (a, left) with Anderson localization in the time dimension (b, right). In order to switch from a space crystal to a time crystal we have to exchange the role of space, z, and time, t; that is, we fix the position in space and ask if the probability of the detection of a particle at this point in space |Ψ(t)|2 is Anderson-localized around a certain moment of time.

In an actual experiment, the probability density of the bouncing ultracold atoms at a particular point in space is recorded, and the atoms appear here with an exponentially localized profile in time (Phys. Rev. A 98 013613). An advantage of studying Anderson localization in the time dimension is that it is relatively straightforward to introduce disorder in a highly controlled way, simply by applying some disorder to the oscillation of the atom mirror. In practice, Anderson localization in the time dimension can be used to control the time of the appearance of a quantum system at a given position by means of a fluctuating force.

Child on a swing

The multidimensionality (3D, 2D or 1D) of space crystals and the interactions between the particles are all elements of condensed-matter systems that physicists can use to build useful devices and to provide scope for inventing novel devices in the future. The analogues of these variables are also available in time crystals – in other words, the degrees of freedom in the time dimension offer an additional “knob” to control the properties of physical systems.

Periodically driven systems have been known for centuries, but not every system perturbed by a periodically changing force would appear to have much to do with condensed-matter systems. For example, a swing driven periodically by a child sitting on it and swinging their legs doesn’t appear to have much in common with an electron moving in a space crystal. But, in fact, there is an analogy between the two. There are resonances when a child on a swing is pushing their legs backwards and forwards with a frequency ω that is an integer multiple of the frequency Ω of the oscillations of the swing (i.e. ω = sΩ, where s is an integer and denotes an s: 1 resonance between the driving force and a system evolving along a periodic trajectory). The behaviour of the swing in the vicinity of the resonant periodic trajectory (the periodic “orbit” in a plot of position against time) is well understood in the theory of dynamical systems. In the reference frame moving with the swing, this behaviour can be described by a model similar to that of an electron in a 1D ring-shaped periodic lattice. For values of s >> 1, in the quantum description, electron energy bands (or more precisely “quasi-energy bands”) form (Phys. Rev. Lett. 111 205303). In other words, a time-periodic crystalline structure is created along a resonant periodic orbit, similar to the periodic lattice in a space crystal.

In space crystals, we usually ask how a system behaves or is structured in space at a given moment of time. In time crystals, we are interested in how a system behaves in time when we focus on its appearance at a given position in space

There is another important property of such a periodic system: any condensed-matter behaviour that we can describe by means of the theory of dynamical systems in the frame moving with the swing is observed in the time domain when we return to the laboratory frame. Thus, in order to observe condensed-matter phenomena in the time dimension, we have to ask the child to push (or drive) resonantly s times faster than the swing’s natural period and we need to stand next to the swing, at some particular position in space, and observe if it is behaving in time like an electron in a space crystal. That is, if we want to switch from space crystals to time crystals we have to exchange the role of space and time. In space crystals, we usually ask how a system behaves or is structured in space at a given moment of time. In time crystals, we are interested in how a system behaves in time when we focus on its appearance at a given position in space. However, condensed-matter phenomena – like an electron in a solid-state system – are described by quantum mechanics. Thus, in order to realize condensed-matter physics in the time dimension, the child needs to drive not a classical swing but a “quantum swing”. This could take the form of any quantum system that in the classical description reveals so-called nonlinear resonances, meaning any periodically driven system except a harmonic oscillator (for which the restoring force is linearly proportional to the displacement). For example, we can exchange the swing with ultracold atoms and the child with a periodically oscillating atom mirror to realize condensed-matter physics in the time dimension (figure 1).

Can we realize non-trivial condensed-matter phases – such as topological insulating phases – in the time dimension? Topological insulators are condensed-matter systems that are insulators in their interior but, by virtue of the topological properties of the electronic structure, have conducting surface (edge) states. They are characterized by global topological invariants. An example of a topological invariant is the number of holes a surface has: a sphere has no holes while a torus has one. It is hard to change such a topological invariant because it is not possible to gradually introduce a hole in a sphere in order to change it to a torus – either there is a hole or there is no hole, but there is nothing like a fraction of a hole. Even the vacuum (empty space) has trivial topological invariants. In order to reconcile a change of this invariant at the interface between the vacuum and a topological insulator, there are surface (edge) states that close the gap between the energy bands of the insulator, thereby producing conducting behaviour.

Can a quantum swing behave like an electron in a topological insulator? Yes, for example if we ask the child to push with a combination of a resonant frequency ω and a sub-harmonic frequency ω/2 (Optica 5 1390, New J. Phys. 21 052003). Then the motion of the swing effectively creates a chain of lattice sites along the resonant orbit with staggered hopping amplitudes, and thus reproduces an example of a topological system, called the Su–Schrieffer–Heeger lattice. In order to observe the edge states, we need to create an “edge” in the motion of the swing and then check if there are quantum states that are localized close to it. How can we create an edge in time? We ask the child to jump on the swing from time to time, which introduces a barrier in the chain of lattice sites along the resonant orbit and consequently breaks the time-translational symmetry along the orbit, similar to how a surface breaks spatial-translational symmetry in an ordinary topological insulator. When we stand next to the swing and the edge of a time lattice is passing by, we can observe that the swing follows the edge if the swing is prepared in a quantum edge state. By contrast, other quantum states of the swing are delocalized along the entire resonant orbit, similar to what bulk states do in ordinary topological insulators.

In a similar way, we can use ultracold atoms bouncing on an oscillating mirror to create a time-crystal equivalent of a topological insulator (New J. Phys. 21 052003). Spatial topological insulators are currently a hot topic in condensed-matter physics, and they have potential applications in many areas such as electronics, spintronics and quantum computers. We now see that topological insulating phases can also be realized in the time dimension and the playground for novel applications is broadened.

From one to many

So far we have discussed how single-particle condensed-matter phenomena can be realized in the time dimension, which can be demonstrated with the help of a BEC of non-interacting atoms, where the BEC acts like a single quantum entity even though it’s a many-particle system. But is many-body physics of interacting particles available in time crystals? Again, the answer is yes, because time crystals built with interacting ultracold atoms bouncing on an oscillating mirror can be effectively described by the Bose–Hubbard model, which is widely used to describe the dynamics of interacting ultracold atoms trapped in a spatially periodic lattice. Modulating the mirror’s motion lets you control and engineer properties of the Bose–Hubbard model, such as the tunnelling rate of particles between neighbouring temporal lattice sites. Furthermore, the application of a magnetically tunable “Feshbach resonance” – which occurs when two colliding atoms resonantly couple to a molecular bound state – allows the interaction between atoms to be precisely controlled.

Even though ultracold (neutral) atoms interact via a short-range potential, interactions in the effective Bose–Hubbard models that describe time crystals can be long-ranged and, moreover, they can be controlled and engineered. Atoms occupying a given localized wave-packet that is evolving along a resonant trajectory interact via short-range interactions in the effective Bose–Hubbard model. However, additionally, atoms occupying different localized wave-packets also interact because the different wave-packets pass each other during the course of the time evolution along a resonant orbit – such transient interactions between atoms result in long-range interactions in the effective Bose–Hubbard model that describes the resonant bouncing of atoms on an oscillating mirror. Moreover, if the original short-range contact interaction is properly modulated in time, by varying the Feshbach magnetic field, one can control the effective interactions and engineer very exotic long-range interactions not available in nature (Phys. Rev. Lett. 120 140401). Implementation of exotic long-range interactions may allow the realization of novel quantum phases and phenomena that are not attainable in conventional systems with crystalline structures in space. Again, the playground for novel applications becomes broader.

Time is a single degree of freedom, so it’s hard to imagine what multi-dimensional time crystals might be. However, time crystals with the properties of 2D or 3D space crystals can nonetheless be created

Time is a single degree of freedom, so it’s hard to imagine what multidimensional time crystals might be. However, time crystals with the properties of 2D or 3D space crystals can nonetheless be created. If, instead of a single oscillating mirror, we prepare two orthogonal oscillating mirrors with atoms bouncing resonantly between them, the resonant dynamics is described by a Bose–Hubbard model corresponding to 2D time lattices, and 2D condensed-matter phenomena can then be investigated in the time dimension (figure 3). When we place a detector at a certain point between the mirrors, the clicking of the detector in time will reproduce the behaviour of a system along a cut of a lattice described by the Bose–Hubbard model. Different locations of the detector correspond to different cuts of the lattice. Such a detection of system behaviour in time allows one to investigate 2D condensed-matter behaviour that emerges in the dynamics of a driven system.

3 Degrees of freedom

Time lattice(a) Atoms bouncing resonantly between two orthogonal oscillating mirrors (graphic courtesy: Artur Miroszewski). (b) Single-shot photo of a time lattice which is effectively described by the 2D Bose–Hubbard model (reprinted from Phys. Rev. Lett. 120 140401).

Suitable modulation of the mirror’s motion also allows one to realize not only time crystals but also quasicrystalline structures in time, which exhibit long-range order but without any periodicity. An example of a quasicrystal is the Fibonacci quasicrystal, like the pattern of florets in the head of a sunflower. A 1D Fibonacci quasicrystal can be created when a suitably chosen line cuts a periodic square lattice. It turns out it’s possible to generate either a 1D Fibonacci quasicrystal in time using atoms bouncing on a single oscillating mirror or to observe the spontaneous formation of a Fibonacci sequence in the time dimension by bouncing atoms between a pair of orthogonal oscillating mirrors (Phys. Rev. B 99 220303).

The world of condensed matter is now entering the fourth dimension of time. Not only is this intriguing in its own right, but it also opens possibilities for novel research directions and maybe new applications and devices. Physicists have predicted that time crystals could be used to experimentally realize exotic long-range interactions that are not available in nature or even in the quantum simulation of condensed-matter systems based on ultracold atoms in spatial optical lattices. The realm of “time engineering” has opened. It’s hard to predict what will emerge in the future. Combining crystalline structures in space and in time should allow novel devices to be built, because processes that cannot be performed together in space dimensions can be realized separately in space and time. In other words, some processes can be performed by the internal dynamics of a system where importantly there is also crystalline structure. Crystalline structures in four dimensions should open new possibilities. Is time–space electronics just around the corner?

German Physical Society cancels Spring Meetings, but innovation continues

The rapid spread of the coronavirus is continuing to affect the international calendar of scientific conferences, with the German Physical Society (DPG) announcing that all three of its Spring Meetings due to take place in Hannover, Dresden and Bonn are now cancelled. “Given the dynamic development in the spread of the virus we do not want to take incalculable risks for all those involved,” the society said in a statement.

The executive board of the DPG says that it “particularly regrets the loss of scientific communication”, while acknowledging that travel restrictions would have limited the opportunities for discussion with international colleagues and research collaborators. Despite the unforeseen circumstances, the organization remains committed to finding alternative formats to enable some form of scientific exchange, with plans to stream part of the Dresden programme online.

Delegates will also miss the chance to learn about the latest improvements in experimental technologies. While nothing beats a face-to-face conversation or live demonstration, here are some of the product innovations that would have been featured at the show, along with full details of how to find out more.

The right lock-in amplifier for your application

Zurich Instruments, a test and measurement specialist based in Switzerland, produces lock-in amplifiers that operate over every frequency range up to 600 MHz. Various upgrades can be added to each of the basic instruments, such as control-loop mechanisms, digitizers or multi-frequency operation, to extend their capabilities for specific applications without needing to invest in unnecessary features.

Zurich

Zurich Instruments’ flagship instrument, the UHFLI lock-in amplifier, delivers state-of-the art performance for applications such as laser spectroscopy and quantum technologies. Thanks to its low time constant for demodulation of 30 ns, its demodulation bandwidth exceeds 5 MHz – which is also ideal for scanning imaging applications that require speeds up to video rate.

The HF2LI lock-in amplifier covers the frequency range from DC to 50 MHz, and is the instrument of choice for characterizing sensors and actuators, as well as for non-destructive testing and medical technologies. Meanwhile, the MFLI lock-in amplifier comes in two versions: one operates up to 500 kHz, while the other extends the frequency range to 5 MHz. Its embedded data and web servers enable it to be used with any device running a web browser, without the need for software installations.

All of the instruments are equipped with the control software LabOne, which offers a comprehensive toolset for time- and frequency-domain data analysis as well as sophisticated support for setting up control loops, performing noise measurements, and visualizing measurement data. Interfaces for most popular programming languages are also available.

Full details are available on Zurich Instruments’ website, or contact info@zhinst.com to arrange a video call.

AFMs enable next-generation characterization

The Dimension XR family of scanning probe microscopes (SPMs) from Bruker incorporate major innovations for atomic force microscopy (AFM) that significantly expand researchers’ ability to quantify material properties at the nanoscale – whether in air, fluids, electrical, or chemically reactive environments. New additions include a unique nanoelectrical mode called DataCube, scanning electrochemical microscopy for energy research, and an AFM-nDMA mode that for the first time correlates polymer nanomechanics to bulk mechanical properties.

Bruker

Dimension XR SPMs are based on Bruker’s popular Icon and FastScan AFM platforms. They are available in three configurations that provide out-of-the-box capabilities for measuring mechanical, electrical, or electrochemical properties at the nanoscale.

To start with, the nanomechanics configuration combines AFM-nDMA with other advanced modes for fast, quantitative analysis of materials ranging from soft hydrogels to metals and hard ceramics. For nanoelectrical applications the Dimension XR configuration delivers the most complete array of electrical AFM techniques on a single system. This includes the new DataCube mode, which captures both electrical and mechanical characteristics in a single measurement, along with several other modes that extend conventional contact-based electrical modes to correlative electrical and mechanical data.

Meanwhile, the NanoEC configuration exploits Bruker’s unique nanoelectrode probes to perform in-situ topography scans in the electrochemical environment, providing a turnkey solution for real-time quantitative analysis of nanoscale local reactivity. This configuration includes an SECM mode that captures topographic, electrochemical, electrical, and mechanical information with a spatial resolution of below 100::nm.

Visit Bruker Nano Surfaces to find out more about Bruker’s full range of instruments for nanoscale surface analysis

Turbomolecular pumps deliver smart monitoring and control

Agilent Technologies has for the first time added smart connectivity to the latest two additions to its extensive range of TwisTorr turbomolecular pumps. An app called Vacuum Link, which can be installed on Apple or Android phones, enables users to communicate remotely with either of the pumps, making it possible to quickly and easily modify parameters and control the pump’s operation.

Agilent Technologies

“Incorporating connectivity into this new range of turbo pumps makes them unique and means users can always stay on top of their experiments,” comments Giampaolo Levi, who heads up Agilent’s Vacuum Products Division. “These pumps are designed to be another milestone move in the digitalization of the lab.”

The two new pumps also feature a more compact design. The TwisTorr 305 FS model is a standalone unit with an external remote controller, while the TwisTorr 305 IC version features an integrated controller. Its small footprint makes it ideal for equipment manufacturers and other companies that may want to integrate the pump in their instrument, and also allows it to be installed in smaller spaces and mounted in any position.

An advanced function in the Vacuum Link app enables users to extract log files to access and share the pump’s operating data. It also enables direct communication with Agilent’s service and support teams, speeding up the response time.

Agilent says that its TwisTorr turbomolecular pumps offer high compression ratios and pumping speeds, and are also reliable and energy efficient. They can also be used with smaller backing pumps to save space and money.

Explore Agilent’s full range of turbomolecular pumps on the company’s website.

Cool technology enables quantum computing

Expert assembly

Researchers attempting to build the next generation of quantum computers are pushing the boundaries of what can be achieved with current experimental technologies. One of the challenges is testing the behaviour of a complex quantum system when it is sealed inside a cryogenic system cooled close to absolute zero. Not only does it make it difficult to assemble, adjust and maintain the components and wiring needed for each experiment, but it can also place practical limits on the size of the quantum system that can be measured.

Finnish company Bluefors has dedicated itself to making life easier for researchers working with such complex experimental systems. Founded in 2008 by two low-temperature physicists, Rob Blaauwgeers and Pieter Vorselman, the company has perfected a series of cryogenic systems that combine high performance with reliability and ease-of-use.

“Many new technologies, including quantum computing, require a controlled measurement environment at temperatures close to absolute zero,” says David Gunnarsson, the company’s chief sales officer. “Cryogenic systems have traditionally been difficult to use and maintain, and our aim is to eliminate those obstacles and enable our users to focus on being creative in their research.”

Bluefors has built its business from developing cryogen-free dilution refrigerators, which avoid the need for liquid helium as a pre-cooling agent. These so-called “dry” systems – which over the last 10 years have become the technology of choice for low-temperature research – make it easier to install samples into the chamber, offer more space for the experimental load, and enable more automation because they require less hands-on attention than previous “wet” systems.

The Bluefors team has exploited their knowledge of the underlying cryogenics technology to build commercial systems that can accommodate large experimental assemblies and can be operated by non-specialists. “Researchers who installed our equipment in their labs realized that everything was so much easier,” comments Gunnarsson, who believes that ongoing improvements in these cryogenic systems have been a crucial enabler for the upswell of commercial interest in quantum computing. “Quantum technology and the development of new cryogenic systems has gone hand in hand, and has driven both technologies forward,” he says.

Bluefors’ strong links with the scientific community has been the lifeblood that has driven continued innovation. A few years ago, in the first of a series of major upgrades, the company equipped its high-performance XLD cryostat with a side-loading system that makes it simpler and more efficient for scientists to design and build their experiments.

“Normally the measurement infrastructure would be assembled inside the cryogenic system, but this restricts access to the components and wiring,” explains Gunnarsson. “Dilution refrigerators are so tall that ladders are needed to reach all the different levels, making it difficult to assemble the measurement equipment without making mistakes.”

In contrast, the side-loading system allows the experimental components and wiring to be fully assembled on the lab bench, and then transferred into the cryogenic system when it is brought up to room temperature. Such an approach allows researchers to easily check that the connections are attached properly, reducing the need for further adjustments when the experiment is installed in the cryostat.

Researchers who installed our equipment in their labs realized that everything was so much easier

David Gunnarsson

The XLD system comes with six side-loading ports, each of which can accommodate the measurement infrastructure for a different experiment. “Many of our customers want to buy one big fridge that can be used for many users performing different experiments at the same time,” says Gunnarsson. “Experiments can be prepared when the system is cold, and then when it is brought up to room temperature the experiments can be changed at the same time. This allows the system to be cooled down more quickly after the maintenance.”

Bluefors has built on this innovation by introducing a modular system that provides a standard way for loading experiments into the cryostat. The components and wiring are assembled inside a module with a standard form factor that simply snaps into the side-loading ports, allowing for quick maintenance of complex assemblies. “The modular system makes it possible to increase the number of wires and components in the system, allows rapid testing and troubleshooting, and ensures quick turn-around for busy multi-user environments,” says Gunnarsson. “All this is done without compromising the thermal properties and strengths of the cryogenic system, which still keeps the operating temperature at millikelvin temperatures.”

Bluefors developed this modular form factor under the framework of the OpenSuperQ project, part of Europe’s Quantum Flagship programme. “It is an open standard that we hope component suppliers will adopt when developing new cryogenic measurement devices,” comments Gunnarsson. “It will make cryogenics a more robust technology, and a standards-based approach should encourage the development of more commercial applications for quantum systems.”

The latest addition to Bluefors’ modular system is the option for high-density wiring, which has become increasingly important as scientists seek to increase the number of qubits in their quantum computing systems. “Until now it has been necessary to attach each component one wire at a time, which is fine for small-scale systems,” says Gunnarsson. “But the footprint of the cryogenic system gets used up quickly as more quantum elements are added, and assembly, installation and maintenance become much more difficult and time-consuming for large numbers of wires and components.”

Density by design

Gunnarsson explains that most experiments in cryogenic systems require several continuous control wires from room temperature down to the lowest temperature in the cryostat. Typically, two or three wires might be needed to control and measure each quantum element – depending on the experimental architecture that has been deployed. The challenge for researchers is how to scale up from lab-scale demonstrations with just a few qubits to more useful quantum computers that will need hundreds of quantum elements.

To address this need, the high-density interface introduced by Bluefors allows researchers to build experiments with more than 1000 high-frequency lines in one system. Making sure that each wire is connected properly is more difficult with such a large number of control lines, so the interface has been designed to allow the wires to be installed in blocks of 12.

The interface exploits standard connectors and coaxial cables for the wiring, and the attenuators have been embedded in a single block that fits into the modular system. Meanwhile, the modular form factor also allows the use of custom components with multiple high-density channels, such as amplifiers, filters and attenuators.

Further into the future, quantum computers are likely to need millions of qubits. It would be impossible to connect that many cables into a cryogenic system, and Gunnarsson says that the research community is still working to develop new technical solutions, such as cold logic and wire multiplexing. “Bluefors is active here and the modular concept will support these developments,” he says.

“Our modular concept makes it possible, now and in the future, to easily maintain a large cryogenic measurement infrastructure,” continues Gunnarsson. “Cryogenics should not be an obstacle that stops anyone from doing an experiment or developing an application; the measurement infrastructure should be readily available so researchers can focus on making their experiment.”

Could bacterial toxins be our next antibiotics?

Hannah Behrens

Using a combination of methods, including X-ray crystallography, small-angle scattering and live-cell imaging, an international research team has probed the structure of a potent new antibacterial agent: PyoS5. By analysing its biophysical and biochemical properties, the scientists – from the University of Oxford, Heinrich Heine University Düsseldorf, the University of Glasgow and the University of Strasbourg – mapped the path by which PyoS5 can be transported into a bacterium (mBio 10.1128/mBio.03230-19).

There is a pressing need for new antibiotics against bacterial pathogens, particularly Gram-negative bacteria, which are responsible for severe acute and chronic infections in humans and are capable of surviving under a variety of environmental conditions. For example, the World Health Organization has classified P. aeruginosa, a Gram-negative, rod-shaped bacterium, a priority pathogen due to its insensitivity to many currently used antibiotics.

Antagonism in bacteria, in which one species kills another, occurs via several routes, the most common being bacteriocin secretion. Bacteriocins are toxins, ranging from small peptides to larger protein molecules, that a bacterium produces to inhibit the growth of competing strain(s). Researchers are currently testing bacteriocins to assess their potential application as antibiotics against multidrug resistant bacteria. One of these, Pyocin S5 (PyoS5), has demonstrated great success in eradicating P. aeruginosa in animal infection models.  However, the import mechanism of the PyoS5 is poorly understood.

Colin Kleanthous

In order to investigate a common import framework, a team led by Colin Kleanthous at the University of Oxford engineered an E. coli bacterium susceptible to PyoS5, as well as other pyocins (such as PyoS4), and proposed a generic pathway taken by these bacteriocins across the outer membrane of Gram-negative bacteria.

The process by which the PyoS5 enters the bacterium can be visualized using the analogy of a ‘fishing pole’. Three components are involved in this import process: CPA, FptA and TonB1. CPA is a surface antigen that, along with the transporter FptA, is located in the outer membrane, whilst TonB1 is present in the inner membrane. PyoS5 first accumulates on the cell surface by binding to CPA. Using its one of the unstructured ends (the N-terminus), elongated PyoS5 then contacts FptA, whilst its associated unstructured region binds TonB1. Both FptA and TonB1 drive the import of bacteriocin across the cell membrane. In addition, the team showed for the first time that PyoS4 also exploits TonB1 for its import.

Bacteriocin import

Universal uptake mechanism

As common principles are beginning to emerge, the researchers believe that these generic import mechanisms will help us to better understand other Gram-negative bacteria that can be destroyed by bacteriocins. For instance, the toxin entry mechanism in two other Gram-negative bacteria families (Enterobacteriales and Pseudomonadales) was long thought to be unrelated. However, these new findings suggest that the underlying mechanism by which some bacteriocins cross the outer membranes are fundamentally the same for both families.

“We think some of these insights likely apply to the whole family of antibiotics, with more than 3000 members,” concludes Hannah Behrens, lead author of the study.

If conferences did post-talk analysis interviews, space lettuce is on the menu, dimming Betelgeuse may just be dust

Some readers may be secretly pleased that conference cancellations have spared them the arduous task of presenting their results at a scientific meeting. Many of us have finished talks feeling like we’ve spent a few rounds in a boxing ring or a period or two on a hockey rink. So why not do a post-talk analysis interview like a professional athlete? This very funny video (below) by the Irish medical researcher Ciaran Fairman shows how it could be done– including how to gracefully critique the unfortunate colour scheme of a senior colleague’s slides.

Lettuce is something we take for granted here on Earth. Lots of different varieties can be found in a supermarket and the leaves can be easily grown in the garden – as long as the slugs can be kept at bay.

But in space, fresh lettuce would be a much-appreciated addition to the usual packaged fare and the leaves also contain more vitamins than prepared foods.

Now, a team led by NASA’s Christina Khodadad has done a study of red romaine lettuce grown on the International Space Station.  They found that the space lettuce is free of disease-causing microbes and is as nutritious as plants grown on Earth.

Safety and nutrition had been concerns because the crop was grown in lower gravity and more intense radiation than found on Earth. However, astronauts did nibble on some leaves before they were tested – suggesting that they weren’t particularly concerned.

Future tests will look at other leafy crops as well as small fruits like peppers and tomatoes. And sorry, but I can’t resist that pointing out that one of Khodadad’s colleagues is called Matthew Romeyn.

For the past few months astronomers have been excitedly watching the nearby star Betelgeuse in anticipation of its explosion. The reason is that the star had been dimming since about the middle of October, which suggested that it could become a supernova. That dimming has since stopped and it now appears that the star is getting brighter – so possibly bad news if you were looking forward to a spectacular explosion.

Emily Levesque of the University of Washington and colleagues have now put forth the theory that Betelgeuse had dimmed because it expelled matter from its surface and this “dust” blocked some starlight. You can find out more in “Dimming Betelgeuse likely isn’t cold, just dusty, new study shows”.

Mars rover launch delayed until 2022

Europe’s Rosalind Franklin rover, which was set to begin its journey to Mars this summer, has had its launch postponed until 2022 amid parachute and electronics difficulties and uncertainty created by the COVID-19 pandemic.

The joint mission between the European Space Agency (ESA) and the Russian space agency Roscosmos, which is designed to seek out evidence of past life on Mars, has already experienced numerous delays during its long development. This latest postponement has been on the cards since tests of the rover’s parachute system, which is designed to safely land the spacecraft on Mars, ended in failure in August 2019.

“We’ve been racing against time in terms of getting everything ready,” says David Parker, director of human and robotic exploration at ESA. “And now we have the coronavirus issue, which is the straw that broke the camel’s back.”

During a meeting between the hierarchies of ESA and Roscosmos, officials decided to delay the launch to allow time for the problems to be fixed. The orbital dynamics of Earth and Mars mean that launch windows only open for a few weeks every two years, to take advantage of the two planets’ closest approach to one another. The mission will now launch sometime between August and October 2022, reaching Mars by April 2023 at the earliest.

A series of glitches

The problem with the parachutes is not the parachutes themselves, but the way that they deploy from inside their protective bags. “They are packed incredibly tightly,” says Parker. “It’s almost a dark art how they are packed.”

During previous “drop-tests”, the main 15m and 35m parachutes developed large tears as they deployed. This prompted a redesign of the protective bags, and two more drop-tests are scheduled for the end of March in the US. However, as coronavirus spreads and travel bans are put in place, these crucial tests are unlikely to happen in time.

A parachute dangling from a gantry above a testing centre

Further complicating matters are troublesome glitches in the electronics units within the Russian lander, Kazachok, which will deploy Rosalind Franklin onto the surface and will carry 13 science instruments of its own. “One of the units will probably have to go back to Russia to be fixed,” says Parker. He adds that the current 14-day quarantine rules in place in Russia make it difficult for teams from Russia and European countries to be in the same place at the same time.

For the rover’s developers, it’s a frustrating, if understandable, development. Andrew Coates, who leads the science team on the rover’s panoramic camera (PanCam), points out that the extra time can be spent performing more simulations of how the rover will perform, with all nine instrument teams involved.

“This will still be a cutting-edge science mission in 2023, as it’s the only mission drilling two metres underneath the harsh surface of Mars and looking for biomarkers and life,” says Coates, a physicist in the Mullard Space Science Laboratory at University College London, UK. “We now just need to wait a bit longer.”

Rossby waves on the Sun provide a tool for forecasting space weather

Weather conditions on Earth are influenced by a phenomenon known as Rossby waves. These planetary-scale fluctuations arise because the Coriolis force – due to the Earth’s rotation – varies with latitude. The resulting pressure system is associated with the jet stream in the atmosphere and also helps govern currents in the oceans.

Within the past decade, Rossby waves have also been observed within the atmosphere of the Sun. While the Earth’s Rossby waves are purely hydrodynamic, the Sun’s Rossby waves are also influenced by the strong magnetic fields at the Sun’s outer layers. In this video interview, space scientist Mausumi Dikpati introduces solar Rossby waves and explains how they can be used to predict space weather, which can pose a threat to the Earth.

Dikpati is a senior scientist at the High Altitude Observatory, a laboratory of the US National Center for Atmospheric Research in Boulder, Colorado. She studies the dynamics between Rossby waves and solar activity such as flares and coronal mass ejections (CMEs). Developing a clear understanding of these processes could lead to mid-term space weather predictions.

Diamond micro-lenses stand up to synchrotron sources

An international team of researchers has produced a stack of diamond micro-lenses precise enough to be compatible with the latest generation of X-ray sources. Physicists led by Polina Medvedskaya at Immanuel Kant Baltic Federal University in Russia developed the intricate structures using ion-beam lithography – a novel approach that could open up new opportunities for compact X-ray microscopy.

Today’s “fourth generation” synchrotrons produce high-quality beams of X-rays that are ideal for imaging. However, advances in the lenses used to shape and condition X-rays have not kept pace with advances in synchrotron technology. When powerful X-ray beams interact with even nanoscale imperfections in lenses, the resulting aberrations fundamentally limit the resolution of the resulting images. This makes it difficult to fully exploit the advantages of modern synchrotrons for X-ray microscopy.

Medvedskaya’s team suggest that this problem could be solved using lenses made from diamond, which has a continuous structure that limits any graininess in the images produced. In addition, the material’s high thermal conductivity and resistance to change at high temperatures would make these lenses able to better withstand intense, high-energy X-ray beams. Furthermore, diamond’s high refractive index means that the optical setup could be more compact than is the case for commonly-used metal and polymer lenses.

Compact stacks of lenses

To create their high-quality lenses, the researchers used beams of ions less than 5 nm in diameter to carve out the lens shapes. This ion-beam lithography technique is commonly used to etch circuits and other high-resolution patterns onto 3D surfaces, and it enabled Medvedskaya and colleagues to produce sets of three diamond half-lenses with curvature radii of just 4.8 µm. They then assembled the lenses into compact stacks using micro-manipulation.

Images of the lenses obtained through scanning electron microscopy revealed that they each had a surface roughness no larger than 30 nm, and an overall curvature accurate to within just 200 nm. In tests at the PETRA-III synchrotron X-ray source at DESY in Germany, Medvedskaya and colleagues used their lenses to focus the hot, intense beams produced by the source down to resolutions of 100 nm.

With further research, the team say their approach could significantly improve the capabilities of modern synchrotron sources, enabling researchers to produce nanoscale-resolution images using a durable, highly compact apparatus. This would be particularly useful for phase-contrast imaging, which exploits differences in the refractive indexes of different materials to precisely differentiate between their structures. If the lens production technique becomes widely adopted, Medvedskaya and colleagues believe it could create diverse new opportunities for research in areas that require reliable shaping and conditioning of X-ray beams.

PET scans could help develop shorter TB treatments

PET/CT scan

Shortening tuberculosis (TB) treatment by optimizing antibiotic dosing may be possible using data acquired from PET/CT scans. In a first-in-human study, scientists successfully measured antibiotic concentration–time profiles in patients with pulmonary TB, an important first step towards the use of PET scans as a tool to optimize TB treatment (Nature Med. 10.1038/s41591-020-0770-2).

Treatment of TB typically requires the patient to take prescription drugs for six or more months. Currently, the typical daily dose of rifampin, a first-line TB drug, is 10 mg/kg; but doses of up to 35 mg/kg per day are safe in adults. Higher drug concentrations at infection sites could more effectively kill pathogens, making treatments shorter, and reducing the risk of failure, relapse and death.

Effective treatment of infections depends upon achieving adequate levels of the antibiotic at the infection sites, where the microbes reside. However, due to the difficulties of directly sampling infected tissues, information on rifampin levels at infection sites has only been available from TB patients with refractory disease, where resections are performed to remove the infected areas.

Principal investigator Sanjay Jain and lead author Alvaro Ordonez, of the Center for Tuberculosis Research at Johns Hopkins University School of Medicine, overcame this challenge using PET/CT with 11C-rifampin, a radiolabelled analogue of rifampin. They acquired area under the concentration–time curve (AUC) data from microdose dynamic 11C-rifampin PET/CT scans. The PET data were then used to determine concentration–time profiles of rifampin at infection sites, which provided a “translational bridge” allowing for pharmacodynamic modelling, according to the authors.

The team performed a multi-institutional study in 12 patients (nine men and three women, aged 19 to 77 years) newly diagnosed with rifampin-susceptible pulmonary TB. Half of the patients had pulmonary cavitation, thick-walled abnormal spaces in the lung, and all had been receiving treatment for at least 10 days prior to their PET/CT scan. The researchers made a total of 1221 measurements, including 473 from infected lung lesions and 748 from uninfected areas including the lung, brain, liver and plasma.

The researchers used the PET data to calculate the tissue-to-plasma AUC ratio for each pathologically distinct lesion using a plasma pharmacokinetics model. The model described the distribution of 11C-rifampin into affected and unaffected lung regions using the concentration–time profiles obtained from the PET data. CT results showed that pulmonary lesions were heterogeneous in different lung regions of a patient. 11C-rifampin exposures in pulmonary TB lesions were low, spatially compartmentalized and demonstrated between- and within-patient variability. The 11C-rifampin AUC tissue-to-plasma ratios were lowest in cavity walls, compared with other TB lesions or unaffected lung.

“This was eye-opening, since cavities are known to harbour the largest number of mycobacteria within infected lungs,” said Ordonez. “Cavitary TB patients are also more likely to fail treatment and spread the disease to other individuals. Rifampin is not getting where we need it most.”

To confirm the human findings, the team performed 11C-rifampin PET/CT on rabbits infected with cavitary TB that closely replicates human pathology, before and after 30–50 days of anti-TB treatment. The PET/CT images also demonstrated limited and spatially compartmentalized 11C-rifampin exposure in TB lesions, with the lowest levels in cavity walls. Post-mortem mass spectrometry in these infected rabbits showed a similar trend to the PET data.

The researchers used the PET data to develop an integrated pharmacokinetics model to predict the 11C-rifampin plasma and tissue concentrations in all patients, and the intra-lesional drug exposure in patients who received daily oral rifampin doses of 10–50 mg kg. With these data, they were able to predict accelerated cure rates based on different rifampin doses. Their results suggest that increasing the dose of rifampin to higher, yet safely tolerated levels, could reduce the treatment course in most TB patients from six to four months.

“This non-invasive approach to measure intralesional pharmacokinetics of antibiotics can also be used in other infections like methicillin-resistant Staphylococcus aureus, or MRSA, which is often treated with long courses of rifampin” Jain says. “We would finally be able to determine the most effective doses of specific drugs in specific patients.”

American Physical Society cancels April Meeting due to coronavirus pandemic

The American Physical Society’s April Meeting has become the latest event in the scientific calendar to be cancelled due to the coronavirus pandemic. The annual particle-physics gathering, which was scheduled to take place in Washington, DC, on 18-21 April, has been called off, with organizers working to set up an online “virtual” meeting in its place.

The announcement came less than 24 hours after DC mayor Muriel Bowser declared both a state of emergency and a public health emergency in the US capital, which has so far reported 10 cases of the novel coronavirus amid widespread reports of testing kits being unavailable or in limited supply. Tours of major public buildings in Washington – including the US Capitol – have been suspended, and schools in neighbouring Loudon County, Virginia have been closed in an effort to limit the virus’ spread.

In a statement, the APS cited concerns for “the health and well-being of its members, attendees, and staff” as well as the local community as reasons for the cancellation. Other factors included the World Health Organization’s 11 March decision to characterize COVID-19 as a pandemic and recommendations that communities adopt “social distancing” measures to reduce the epidemic’s speed and severity.

Details of the planned “virtual” meeting were not immediately available, but there is a growing precedent for such events within the physics community. After the APS March Meeting, which focuses on condensed-matter physics, was cancelled earlier this month, a group of would-be attendees set up a “virtual meeting” website. As of 12 March, some 150 talks had been uploaded to the website, which by then had 8000 users and received 50,000 page views. The American Association of Physicists in Medicine has also elected to turn its spring clinical meeting – which had been scheduled to take place in Minneapolis, Minnesota on 4-7 April – into a virtual event.

Participants who registered to attend the APS April Meeting will receive a refund of their fees. An official letter of cancellation is also available to help registrants cancel or claim back the cost of flights and accommodation. More information is available here.

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