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Being open to new concepts should apply to physicists as well as physics

Pride colours in various logos

Scientists are often driven by a need to classify the world around them. Physics can equip us with a broad range of concepts and analyses that ought, in principle, to make us open minded not just in terms of science but in our day-to-day lives too. Nevertheless, many physicists who identify as LGBT+ still face challenges based on their identity.

Gender and sexuality are no longer defined the moment a person is born or by the way they may look, and despite some presumptions, the two need not be correlated in any way. Today, the concepts of being lesbian, gay, bisexual and transgender are not only  in the public consciousness but also increasingly accepted as a part of the norm, meaning that now is an exciting time to be openly exploring one’s own identity.

Less familiar are terms encompassed by the ‘+’ in LGBT+, which highlights the ever growing list of identities coming to prominence, including asexual, aromantic, pansexual, agender, non-binary and demisexual. As we come across more and more identities, it is clear that gender and sexuality, which one may assume are discretely quantized groups, instead lie in spectra on which different people place themselves and indeed may move across throughout their lives.

There is an analogy with the electromagnetic spectrum, which was built from the discovery of different forms of light such as visible, infrared and X-rays. These categories exist because of their construction within man-made boundaries as opposed to any physical boundaries, but we always know the spectrum is continuous. Likewise, with sexual or gender identity, the categories – gay, straight, male, female and so on – are in place for convenience and because of their historical foundations. In reality, a spectrum works as a much better model, but is often overlooked because most people tend to place themselves at one end or the other of these spectra. Coincidentally, the visible region ties in very neatly with the rainbow pride flag, a key symbol of the LGBT+ community.

A survey published in March 2016 by the American Physical Society – LGBT Climate in Physics – provides some insight into the current condition for LGBT+ physicists (see May 2016 p11). Notably, 20% of respondents stated that they had experienced exclusionary behaviour based on sexual/gender identity in the previous year, with about half having come “out” in the workplace. Somewhat alarmingly, 40% agreed with the statement that “Employees are expected to not act too gay,” demonstrating a culture that is far from entirely inclusive.

A fluid concept

Regrettably, several factors prevent a thorough analysis of the current opinions of LGBT+ scientists. Surveys, anonymous or otherwise, cannot account for those who remain firmly “in the closet” or who may feel unable to voice their actual opinions for fear of being “outed”. Furthermore, sexuality and gender identity are not necessarily static, but can be in flux throughout an individual’s life, meaning that these surveys may present only a snapshot of one moment in time.

It is no real secret that science, technology, engineering and mathematics (STEM) subjects are largely a straight, male-dominated environment. Few LGBT+ figureheads exist, and those who do are often remembered solely for their contributions to science rather than as a person. More recently, incidents where noticeboards for an LGBT+ group at the CERN particle-physics lab were vandalized shows a shocking lack of tolerance from some of the most brilliant minds in the field (see March 2016 pp31–36).

Larger companies and universities often have mandatory diversity training courses that bring these issues to prominence, but particularly in the STEM workplace, LGBT+ people feel under-represented and unable to bring their complete selves to work. Some would argue that your identity as a physicist should not affect your work since any fundamental physical concept will not be changed by the person investigating it. But we are not machine-like in our labour. If someone who is transgender uses the bathroom of the gender they identify with, say, and is regularly met with hesitant or even aggressive glances from colleagues, it will quickly have a negative impact on their work.

Inevitably there will be opposition to the idea of sexuality and gender as individual spectra. Indeed, as scientists it is to our advantage to be scrupulous with new ideas and to harbour a healthy level of scepticism. This is relatively harmless when a physical concept is being explored, but when this is being applied to the identity of an individual, much more is at stake.

If a heterosexual, cisgender (someone who identifies as the same gender they were assigned at birth) physicist were to claim that an asexual-panromantic-trans-man was statistically so rare that they probably did not exist, they would be denying an entire group of people their identity. If one person from this group comes forward and falsifies this theory, some scientists might claim that this person must be “confused” or “going through a phase”, as is so often presumed by those whose identity lies comfortably in the majority.

Even if we feel that we may have more impartial judgement as scientists given our skills for analysing and presenting data, social, political and religious concepts of sexuality and gender in such circumstances inevitably come into play. Crucially, people cannot be viewed as data. Despite the fact we may like to fully understand every aspect governing gender identity and sexual orientation, whether this is rooted in biology, psychology or something else altogether, it seems unlikely to me that we can possibly create a single system to successfully categorize a planet full of different people.

Our priorities lie not in finding an answer, but in amplifying the conversation about tolerance and openness to new or unfamiliar concepts. After all, is this not the mindset we already use in learning and exploring physics?

Happy birthday Curiosity, overpaid footballers, cheeky Einstein photo sells

By Sarah Tesh, Hamish Johnston and Michael Banks

It’s Mars Curiosity’s 5th birthday tomorrow! The NASA rover touched down on 5 August 2012 and has been exploring the red planet ever since. It has travelled more than 10 miles, studied more than 600 vertical feet of rock and even proved that Mars was once habitable. While a Mars birthday party for Curiosity would be a lonely affair, researchers at NASA Goddard Space Flight Center have programmed the rover to sing “Happy birthday” to itself using its Sample Analysis at Mars (SAM) instrument. To introduce ground samples into the rover, SAM resonates through a range of frequencies, so the researchers programmed the instrument to run through the frequencies of the celebratory song.

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Quark–gluon plasmas rotate at record speed

The fastest rotating fluid ever seen has been created by an international team of physicists working on the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory in the US. The record-breaking vortices are quark–gluon plasmas (QGPs), which are made by smashing gold ions together at energies up to 200 GeV.

QGPs can be thought of as tiny versions of the universe shortly after the Big Bang – and studying their rotation could provide insight into both the early universe and the strong force that binds quarks together.

A QGP is created in a high-energy collision when the quarks and gluons that make up protons and neutrons become de-confined and create a hot, dense fluid-like state of matter. These collisions are rarely perfectly head on, so the resulting QGP can be left spinning with extremely high angular momentum.

Intrinsic spins

The rotation of the QGP cannot be measured directly and instead physicists working on the STAR detector at RHIC look at hadrons that are emitted from the QGP as it rotates. The intrinsic spins of these particles tend to be aligned with the angular rotation of the QGP, so the challenge becomes how to measure their intrinsic spins. Fortunately one of these hadrons – the Lambda; hyperon – decays rapidly to a proton and a pion – and the proton tends to be emitted along the direction of the Λ hyperon’s intrinsic spin.

The team tracks the proton and pion as they travel through the STAR detector. Because the two particles have opposite electrical charge, they are deflected in opposite directions by the detector’s electric and magnetic fields. The result is a distinct set of tracks that can be traced back to the Λ hyperon (see figure).

Faster than superfluid helium

By studying the intrinsic spin of the ejected Λ hyperons, the team worked out that the QGPs spin at a rate of about 1022 rotations per second. This makes them the fastest fluid vortex ever observed. Their speed is many orders of magnitude faster than a tornado, Jupiter’s red spot and even the previous record holder – vortices in superfluid helium that have been clocked at 107 rotations per second.

Studying QGPs should provide important information about the state of the universe shortly after the Big Bang, when the cosmos was itself a plasma of quarks and gluons. After a short while, this primordial QGP cooled to form the familiar hadrons (protons and neutrons) that comprise most matter today – and physicists are very interested in knowing exactly how this phase transition occurs. By studying the rotational properties of QGPs made here on Earth, physicists should gain important insight into the collective properties of QGPs that drove this transition.

Magnetic measurements

STAR physicists are also looking forward to using Λ hyperon measurements to study the extremely strong magnetic fields that are expected to exist in a QGP, because these fields affect how particles are ejected from the QGP.

The study is described in Nature.

Hubble detects hot exoplanet’s stratosphere

The strongest evidence to date for an exoplanet stratosphere has been identified by scientists using NASA’s Hubble Space Telescope. Spectra of WASP-121b’s atmosphere are the first to show the resolved signature of hot-water molecules for a planet outside the solar system.

A planet’s stratosphere is a layer of atmosphere where temperatures increase with altitude. For example, Earth’s stratosphere contains ozone gas that traps ultraviolet radiation from the Sun, raising the temperature within the layer. Meanwhile, on Jupiter and Saturn’s moon, Titan, methane is behind the temperature increase.

Boiling metal

WASP-121b is a “hot Jupiter” – a gas giant with 1.2 times the mass of Jupiter and 1.9 times the radius and a much higher temperature. Located about 900 light-years away, it orbits the star WASP-121 in just 1.3 days, and the planet’s close proximity to the star means the top of its atmosphere reaches 2500 °C – so hot that some metals can boil.

While previous research has found possible signs of stratospheres on other exoplanets, the evidence of water on WASP-121b is the best to date. Thomas Evans from the University of Exeter in the UK and colleagues identified the water because it has a very distinct and predictable interaction with light, depending on its temperature. If there is cool water at the top of the atmosphere, the molecules will prevent certain wavelengths of light (typically infrared due to heating) from escaping the planet. On the other hand, if the water is hot, the molecules will “glow” at the same infrared wavelength. “When we pointed Hubble at WASP-121b,” says Evans, “we saw glowing water molecules, implying that the planet has a strong stratosphere.”

Unknown gaseous cause

The temperature change within stratospheres of solar-system planets is typically around 56 °C, but on WASP-121b the temperature rises by 560 °C. The researchers do not know what chemicals are causing this rise in temperature, but possible candidates include vanadium oxide and titanium oxide because they are gaseous under such high temperatures and are commonly seen in brown-dwarf stars, which have similarities to some exoplanets.

“This result is exciting because it shows that a common trait of most of the atmospheres in our solar system – a warm stratosphere – also can be found in exoplanet atmospheres,” says team member Mark Marley at NASA’s Ames Research Center in the US. “We can now compare processes in exoplanet atmospheres with the same processes that happen under different sets of conditions in our own solar system.”

The work is presented in Nature.

Protein-capturing nanoparticles boost immune response to cancer

Scientists have improved cancer treatments in recent years by combining radiation therapy with immunotherapy. Now, researchers in the US and China have engineered nanoparticles to improve outcomes further. The nanoparticles capture tumour-derived proteins at the treatment site, providing a kick to the immune system and enabling it to detect and respond to cancer cells elsewhere in the body.

On its own, radiation therapy works by damaging cancer cells’ DNA, killing them and preventing them from propagating their defective genetic material. Immune cells arriving at the tumour site after irradiation use mutated proteins released by the dying cells to coach other immune cells into recognising and fighting cancer elsewhere. This phenomenon is known as the abscopal effect, and it results in tumour shrinkage even outside of the sites targeted with radiation therapy. Immunotherapy drugs known as checkpoint inhibitors are given alongside radiation therapy to help the body’s immune system marshal its attack on cancerous cells.

Writing in Nature Nanotechnology, a group comprising scientists at the University of North Carolina, Duke University Medical Center and Memorial Sloan-Kettering Cancer in the US, and Xuzhou Medical University in China, outline how antigen-capturing nanoparticles (AC-NPs) can enhance the abscopal effect by attaching themselves to tumour-derived protein antigens (TDPAs). The increase in immune response is thought to result from the size of the nanoparticles, which make the TDPAs much more attractive to the immune system. When TDPAs are bound to nanoparticles, the body mistakes them for something foreign such a virus, and responds more aggressively.

Starting with nanoparticles made from PGLA, a biocompatible and biodegradable polymer, the researchers prepared several formulations of AC-NPs by surface modification. Different coatings were attached to the AC-NPs through a number of mechanisms, and the group found that the surface chemistry determined the diversity and composition of the proteins captured.

The attachment of TDPAs to AC-NPs was shown to translate to a more robust activation of T-lymphocytes (T-cells), which play a central role in cell immunity. This increased therapeutic effect led to improved survival when tested in mice. The scientists found that 20% of the mice had a complete response rate when treated with the nanoparticles alongside radiation therapy, compared to none of those mice that received radiation therapy alone. Additionally, when the nanoparticle-treated mice were re-injected with cancerous cells three months after treatment, the mice rejected the cells, demonstrating that the treatment strategy outlined induces a durable response, increasing immunity to the tumours long-term.

Traditional methods of immunotherapy focus on administering one or several chosen antigens. The researchers believe that the limited success of this approach could be due to its failure to take into account diversity in tumour cells. The novel method outlined here is more promising as the immune system is exposed to a wide variety of TDPAs in a patient-specific manner. This offers opportunities for the future in precise and personalized medicines when treating patients suffering from extensive cancers.

Full details of the research are reported in Nature Nanotechnology.

3D-printed blood vessels reproduce patient clots

Blood clots in an artery – otherwise referred to as an arterial thrombosis – are potentially fatal, and are a major risk factor leading to strokes and heart attacks. One way to study this problem in the lab is to exploit precise manufacturing techniques like 3D printing, and mimicking the interaction between vessel walls and blood flow is critical to effectively replicating healthy and diseased blood vessels in vitro.

Researchers in the Netherlands have now created a more accurate blood-vessel model that effectively replicates the formation of a blood clot caused by stenosis defects, the narrowing of a blood vessel that can lead to disease (Lab on a Chip 18 1). The researchers, from the University of Twente and Utrecht University, developed a microfluidic blood-vessel model using layered stacks of computed tomography angiography (CTA) data combined with sterolithography, a light-based 3D-printing process.

To create the model, the researchers first 3D printed a negative mould with the precise blood-vessel structure. They then poured a mixture of polydimethylsiloxane (PDMS) and a crosslinking agent mixture into the mould, which was then cured to create the vessel channel. By lining the vessel channel with endothelial cells and perfusing patient blood at normal arterial shear rates, the researchers established the platelet aggregation that forms a blood clot, and they also observed an increase in the backflow downstream of the stenosis defect.

Improvements in geometry

The anatomically accurate blood vessel model developed by these researchers achieves an even distribution of shear stress across the vessel, which makes it much more clinically relevant than typical in vitro models. The key difference is the geometry of the fabricated blood vessel, since most previous microfluidic models have been produced with a square channel where vessel cells can be seeded and perfusion can occur. These square channel walls do not provide an accurate representation of a blood vessel, with differing shear forces being applied to the corners and flat sections of the square vessel.

Results produced from this 3D model can be cross-referenced easily with fluid-flow simulations in silico to instil a systems biology approach to research, and the researchers believe the use of patient CTA data could lead to the development of patient specific blood-vessel models. The resolution and control of the blood vessels produced by the technique also makes it suitable for modelling alternative vascular diseases, including chronic conditions like vascular dementia. Further development of this model could eventually lead to a fully stratified approach to vascular disease research, which in turn would reduce the number of animals used in research studies.

Nanoscale imaging looks deep into magnetic materials

A new technique for taking nanoscale images of the magnetic properties of materials has been unveiled by researchers in Switzerland. Unlike other nanoscale imaging methods, the technique can reach deep into a sample, and the team believes that it could provide new insights into the physics of magnetism and optimize magnets for a wide range of industrial applications including data storage.

Nanoscale images of magnetic structures can be obtained using low-energy “soft” X-rays or electrons. However, these can only penetrate 100–200 nm into a material and this restricts them to studying thin films and the surfaces of bulk materials. Neutrons can probe much deeper into materials, but their resolution is limited to 35–100 μm. Higher-resolution images of internal magnetic structure have been obtained only by techniques that destroy the material.

Higher-energy “hard” X-rays penetrate much deeper into materials and are used in tomography. However, magnetic interactions involving X-rays are very weak and magnetic tomography – which involves measuring three components of the magnetic field at every point inside an object – is fiendishly difficult.

Circular dichroism

Now, researchers at ETH Zürich and the Paul Scherrer Institute have developed a new imaging technique that allows researchers to do this using a phenomenon called X-ray magnetic circular dichroism.

“When you have circularly polarized light, and you are near the absorption edge of a magnetic material,” explains ETH Zürich’s Claire Donnelly, “you have preferential absorption of a certain spin for a certain polarization of light.”

The researchers scanned a hard X-ray beam over the surface of a 5 μm-diameter micropillar of the intermetallic magnetic compound GdCO2. They recorded the change in the diffraction pattern as they rotated the pillar through 360°. The researchers then tilted the pillar through 30° about a different axis and repeated the process. Using a computer algorithm of their own design, the researchers used the data to reconstruct the magnetism at each point in the pillar with a spatial resolution of around 100 nm.

Bloch points

This allowed the team to make the first-ever direct experimental observations of Bloch points. These are monopole-like points where magnetic domains point in different directions. “These are not true Dirac monopoles of the kind everybody likes to make a fuss about,” says team member Sebastian Gliga, now at the University of Glasgow. “They are points of divergence of the magnetization within a material, which are fully allowed by Maxwell’s equations.”

The existence of Bloch points has been generally accepted for decades, and they were even used in a type of computer memory called bubble memory in the 1970s and 1980s. Until now, however, no technology has been able to image the magnetic domains around them. The team confirmed that the Bloch points are surrounded by circulating magnetic flux, which theoretical models predict is more stable than “hedgehog” Bloch points with all the domains pointing towards or away from one point. It also observed twisted “anti-Bloch” points for the first time.

The researchers believe the technique opens significant opportunity to explore magnetism: “Now we have the possibility to look inside these unconfined, bulk magnetic systems to see how they react to the application of a magnetic field, or to different temperatures,” says Donnelly. Her colleague Manuel Guizar-Sicairos of the Paul Scherrer Institute believes it also has significant industrial potential: “Once you can look into the internal structure and predict the bulk performance of the magnet, then you can tailor your production methods to create the properties that you want, such as greater efficiency, greater power or whatever.”

Speeding up

Peter Fischer of Lawrence Berkeley National Laboratory in California, who was not involved in the research, says it is “an achievement in demonstrating technique” and is well placed to take advantage of new fourth-generation coherent X-ray light sources: “This technique relies heavily on coherence,” he says. “The promise is that, whereas it took Claire Donnelly a day or two to collect the data, 10 years down the road it might be possible in a couple of minutes, because we have so much higher flux of coherent X-rays in the new facilities coming online as we speak. With this will come better spatial resolution.”

The technique is unveiled in Nature.

New nanostructured device boosts infrared spectroscopy

A new metamaterial nanostructure designed for infrared-based spectroscopy traps 27 times more light than similar devices. Developed by scientists in the US and China, the structure could be used to improve the detection of drugs, bomb-making materials and other chemicals.

Infrared absorption spectroscopy is used to identify chemical composition. It works by shining infrared light onto a sample and characterizing the molecules by the wavelengths that are absorbed. One version of the technique is surface-enhanced infrared absorption spectroscopy (SEIRA). Metallic nanostructures in the vicinity of a sample concentrate infrared light, resulting in a significant enhancement of the absorption process.

Reduce the gap

To further boost SEIRA performance, the gaps between the metallic nanostructures can be reduced to further confine the light. However, it is difficult to squeeze light – particularly the mid-infrared wavelengths used in SEIRA – with high efficiency into such small dimensions because of the conventional optical diffraction limit.

Now, Qiaoqiang Gan from the State University of New York at Buffalo in the US and colleagues have developed a promising solution – a metamaterial super absorber structure that acts as a substrate for sample chemicals. Made using atomic layer deposition, the corrugated metallic structure contains insulating gaps smaller than 5 nm. These trap light with 81% efficiency, compared to previous structures that have 3% efficiency.

Great potential

The team’s substrate can boost SEIRA such that it can detect molecules at 100 to 1000 times greater resolution than previous studies. “This new optical device has the potential to improve our abilities to detect all sorts of biological and chemical samples,” says Gan.

The work is presented in Advanced Optical Materials.

A shared journey of discovery

They may be your childhood co-conspirator or tormentor, your present-day source of pride or envy, but whatever your relationship with your sibling, one thing rarely changes: for better or worse, you are stuck with them for life. By the time they are 11, children who have siblings spend a third of their time – more than with their friends, parents, teachers or on their own – with their brothers or sisters. This intimacy, and the learning and friction that go along with it, means the sibling relationship is one of the most important in moulding an individual’s adult personality. And for those who have caught the physics bug early in life, it can provide the bedrock for staggering success.

From Sophia and Tycho Brahe’s astronomical observations in the 16th century – some of the most accurate to be made without a telescope – to Frank and J Robert Oppenheimer collaborating on the Manhattan Project, examples of successful sibling scientists can be found throughout history. Some, like the Bernoulli clan whose contributions to mathematics and physics stretch over a century, were born into it. Others, like the Wright brothers, drew strength from their mutual love of science to achieve something great. All gained inspiration from their close bond with their sibling.

Brothers in astrophysics

Identical twins Dale and Dan Kocevski are both astrophysicists in the US, at Colby College in Maine and NASA’s Marshall Space Flight Center in Alabama, respectively. Coming from a blue-collar family, and the first in their family to go to college, from an early age the Kocevski twins constantly looked to each other for support in pursuing their nascent scientific interests. “We would take just about anything we could apart to see how it worked and mix random ingredients together from the kitchen in the hope of a chemical reaction,” says Dan. “We often reinforced each other’s preoccupation with science,” agrees Dale. “We attended NASA’s Space Camp in Huntsville, Alabama together and we read a lot and often shared the plots of our respective books, in some sense doubling the number we were reading!” But all this changed at the turn of the century after their bachelor degrees at the University of Michigan.

Twins Dale (left) and Dan (right) Kocevski

“We had pretty much spent our entire lives together before going away for grad school,” says Dan. “The loss of the implicit support that comes from having a sibling going through the same challenges was definitely a big deal.” Although they both developed PhD thesis projects related to high-energy astrophysics, their sub-fields – gamma rays for Dan and X-rays for Dale – were worlds apart, meaning the brothers worked on different problems for the first time. “It was a huge change, both academically and personally – it was the first time in our lives that we had lived apart,” says Dale.

Today, while Dale is focused on how galaxies and their supermassive black holes evolve together using observations ranging from X-rays to the infrared, Dan studies the universe through gamma-ray bursts, most recently in relation to searching for the electromagnetic counterpart of the gravitational wave detections made by the Laser Interferometer Gravitational-Wave Observatory.

This means that despite both working in astrophysics, their professional lives are now largely separate, except for one conference a year that brings them together: the annual American Astronomical Society meeting. “It makes for fun stories when we attend the same conference – I’ve had people tell me how much they liked my talk, only to realize that they were referring to my brother’s talk from earlier in the meeting,” says Dan. “I often wonder how many positions I’ve obtained because people erroneously assumed that I was publishing twice as many papers as I was and on two entirely different fields of astronomy.”

Sharing the same experiences and going through the same changes through childhood, the Kocevski twins are a prime example of how a sibling’s behaviour both influences and is influenced by their brother or sister, in this case in a very positive way.

This contrasts with the commonly held view that rivalry plays a major part in driving siblings to excel in a particular topic. But human development and family expert Kathi Conger from the University of California, Davis, thinks this is a popular misconception. “Negative emotions and feelings are often the focus because that is the stereotype of what people expect about sibling relationships,” she says. While Conger acknowledges there is always the possibility of personality clashes, she says that “the notion of sibling rivalry is overstated in the popular literature”. In fact, a much stronger influence is social learning – the simple act of observation and emulation.

The astronaut and the astrophysicist

For siblings with a large age difference, early-life social learning is more of a one-way affair. Astronomy professor at the University of Kansas and former NASA astronaut Steve Hawley is seven years older than his University of Virginia astrophysicist brother John. “Steve led the way into astronomy for me,” notes John. “I have an early memory of his receiving a telescope as a Christmas present and some number of years later he got a better telescope and gave me the first one as a hand-me-down.”

Despite the age gap, the Hawley brothers’ careers have been strangely intertwined. Prior to his selection by NASA in 1978, Steve conducted seminal work into the nature of peculiar remote elliptical galaxies known as BL Lac objects, which John later followed up by helping to understand the physics underlying them. Then, as a NASA astronaut, Steve serviced the Hubble Space Telescope and the Chandra X-ray Observatory (five trips into space in total), both instruments later providing major discoveries in high-energy astrophysics, which is John’s specialism.

Since then, John has had great success, including sharing the 2013 Shaw Prize in Astronomy with former colleague Steven Balbus for the “discovery and elucidation of the magnetorotational instability”, an important part of the dynamics in accretion discs. “I always remark that the big change was going from people asking me ‘are you related to Steve Hawley?’ to today Steve being asked ‘are you related to John Hawley?’,” jokes John. “Good symmetry there, although his Wikipedia article is much longer than mine.”

Academic heritage

Even if John’s comment is light-hearted, using a brother or sister as a yardstick for your career achievement turns out to be quite common and useful. “Because Rosemary is almost six years older than me, she’s always further along her career path,” explains Louise Dyson, an applied mathematician at the University of Warwick, UK. “I do somewhat measure myself against what she was doing when she was at my stage, and I expect in some ways I always will.”

Louise’s research supports efforts to eradicate neglected tropical diseases. In one ongoing study, she devises models of parasitic worms such as roundworm, which infect the intestine and are transmitted through contaminated soil. Her models focus on the interactions between different parasites when they simultaneously infect a host. Meanwhile, her sister Rosemary is also an applied mathematician but her work at the University of Birmingham aims to understand how plants grow, including modelling the growth of plant roots at a range of scales, as well as the interactions between cells and their extracellular matrix. “I’m also working on an industrial project aiming to produce handheld testing devices that can determine whether there are nasty bugs in your water supply, or blood or urine sample, cheaply, quickly and easily,” she adds.

The Dyson sisters come from an academic family – their mother was a mathematician – so from the outside it was little wonder both sisters followed in their mother’s footsteps. Yet while they were growing up, the very idea of also becoming mathematicians was anathema to them. “It seemed a bit boring if we all ended up doing the same thing,” explains Louise, adding, however, that in the end, maths turned out to be fun after all. Rosemary agrees that they both decided to “do what we were interested in and didn’t let the fact that we wanted to rebel against tradition stop us”.

Family expert Conger says that siblings can be an important source of information, especially if they are working in the same or a related field. They can offer advice and encouragement about the culture of competition and collaboration, share ideas for funding sources, provide feedback on job applications or even help one another in areas outside their immediate expertise. This has been Rosemary’s experience, who has found that her younger sister’s know-how has grown increasingly academically useful in her own work: “She has some really interesting research knowledge and ideas, and I now use her as a resource much more than I used to.”

Family magnetism

But what about siblings who choose wildly different career paths? Does the sibling relationship still confer an advantage in adulthood? All siblings described so far (in this admittedly unscientific sample) seem to share a deep desire to rekindle the closeness of the early-life sibling relationship in later years. However, the gravitational pull is palpable too in siblings who have entirely unrelated expertise, often leading to unusual and impactful results.

Scientist sisters Sheila (middle) and Nikki (right) Kanani

The parents of space scientist Sheila, and GP and chief clinical officer Nikki Kanani, surrounded their daughters from a young age with piles of books on human medicine, biology, veterinary science and maps of the universe. Very early on, Sheila decided she wanted to be an astronaut and Nikki a doctor. “We enjoyed the fact that we didn’t have to compete because we were on such different paths,” says Sheila. “We both made our own choices and weren’t compared to each other so we could each flourish as our own person.”

Although they could not support each other academically, Sheila found that having a sister who believed in her “wild” career aspirations gave her the impetus to carry on: “I never felt silly talking to her about what interested me and what I wanted to do ‘when I grow up’,” she says. “Life would be very different without my sister around!”

What is interesting with the Kanani sisters is that despite working in very different areas, they found a topic where they could join forces. “In December 2012 we decided to try and support people from communities that may not be able to access STEMM (science, technology, engineering, maths and medicine) subjects – and STEMMsisters was born,” explains Sheila. STEMMsisters is an online social network that includes mentoring, events and a blog, all of which aim to connect, inspire and empower anyone interested in the STEMM subjects. “We have similar strengths but also both bring different ideas to the table and we bounce off each other very well,” says Sheila. “Working with your sister is super fun: like doing your dream job with your best friend!”

Quantum connection

An even more extreme example of sibling collaboration can be seen in Rutgers University condensed-matter physicist Piers and his younger brother Jaz Coleman, who is the co-founder of, and singer in, the hugely successful industrial rock group Killing Joke. With one brother travelling the world as an international rock star and the other studiously advancing the theory of strongly correlated electron systems, the Colemans’ worlds could not be further apart. Yet at the start of the century they found a way to collaborate. Music of the Quantum merged Piers’ knowledge of quantum mechanics with Jaz’s musical skills to create an original musical composition about the quantum world.

Brothers Jaz (left) and Piers (right) Coleman

“One of the things I told Jaz was that quantum mechanics allowed things to be in two states at once, and that perhaps we could try to capture this in the music,” says Piers. “Jaz had the idea of using a violin and an accordion to capture these two states.” Music of the Quantum was first performed in New York at Columbia University in 2003 and then in 2004 at the Bethlehem Chapel, Prague. “It was immense fun, though a huge undertaking,” says Piers. “We hope to perform Music of the Quantum again live in London. I love the idea that art and science are not so far apart – the idea that they can synergize one another.”

Clearly, siblings can have a big effect on each other’s life course. From the very beginning, the bickering, fighting and arguing that is usually frowned upon or punished by parents can confer an advantage when it comes to problem-solving in adulthood – a key tool for any scientist. “It seems likely that siblings who learn to resolve conflicts are in a better position to state their case clearly, take a stand and stick up for their point of view,” Conger says. “My research found that sibling problem-solving skills contributed to an adolescent’s sense of mastery and control even after taking into account problem-solving with parents.”

By negotiating new roles and responsibilities outside the home, and incorporating new relationships into their lives, at some point, however, family relationships – including those between siblings – start to become less central to everyday life. But once established in their careers and settled in their family lives, that familiar bond often seems to once again tug siblings back together. And with the angst and rivalries in the past, the warmth of the bond restored, and knowledge from a lifetime devoted to their passions at their fingertips, older sibling pairs can become more than the sum of their parts in achieving great things side by side.

Historical sibling scientists

Uranus and two of its moons

Gifted siblings litter science’s annals with huge achievements. Here is just a small selection of some of the most notable.

Tycho (1546–1601) and Sophia (1559–1643) Brahe
The youngest of 10 children born to Danish high nobility, Sophia Brahe taught herself astronomy, astrology, mathematics, chemistry, medicine, genealogy, botany, literature and German. She assisted elder brother Tycho in his astronomical observations – some of the last to be done with the naked eye – which produced by far the most accurate measurements of the positions of the planets and astronomical objects at that time and led to new understanding of what comets and what we now know as supernovae are.

The Bernoulli mathematicians (1654–1789)
Hailing from Basel, Switzerland, various Bernoullis made a huge impact on mathematics in the 17th and 18th centuries. Brothers Johann and Jacob inspired and competed with one another, leading to progress in infinitesimal calculus, including the development of the calculus of variations. Johann’s sons Nicolaus, Daniel and Johann II, and even his grandchildren also became accomplished mathematicians and teachers. Daniel Bernoulli, in particular, is today known for Bernoulli’s principle on the inverse relationship between the speed and pressure of a fluid or gas.

William (1738–1822) and Caroline (1750–1848) Herschel
The first professional astronomer, German-born William Herschel is probably best known for discovering Uranus and its moons Titania and Oberon, as well as discovering the Saturnian moons Enceladus and Mimas, and importantly, was the first person to identify infrared radiation. Meanwhile, sister Caroline assisting in the shadow of her esteemed brother was the first woman to discover a comet, to be paid for scientific services and to receive an honorary membership into the Royal Society. Until 1996 she was the only woman to receive the Gold Medal from the Royal Astronomical Society.

J Robert (1904–1967) and Frank (1912–1985) Oppenheimer
J Robert Oppenheimer was an American theoretical physicist, who made important contributions to theoretical astrophysics, nuclear physics, spectroscopy and quantum field theory. Frank was inspired to follow in his older brother’s footsteps, which eventually led to him collaborating with Robert, who was director of the Manhattan Project, on the creation of the atomic bomb. However, Frank’s brief dalliance with the Communist Party in the 1930s put an end to his scientific career after the Second World War and damaged his brother’s. Later, Frank recovered by founding San Francisco’s Exploratorium in 1969, which has inspired science museums worldwide ever since.

Antimatter hyperfine splitting is measured at CERN

An antimatter experiment at CERN reveals that the hyperfine splitting of antihydrogen is the same as that of hydrogen to four parts in 10,000. The research was done by physicists working on the ALPHA-2 experiment, who describe the work as an important step towards measuring the spectral lines of antihydrogen – something that could lead to the discovery of new physics.

Antihydrogen is the antimatter version of hydrogen and comprises an antiproton bound with an antielectron (positron). According to the Standard Model of particle physics, physical properties of antihydrogen such as hyperfine splitting should be identical to that of hydrogen. Physicists are therefore very keen to find discrepancies between hydrogen and antihydrogen, which would point to new physics beyond the Standard Model. Such a discovery could, for example, help explain why there is much more matter than antimatter in the universe.

In atomic hydrogen, hyperfine splitting is a result of the interaction between the magnetic moments of the nucleus and the electron. This splitting has been measured to a precision of seven parts in 1013 – providing the first evidence for the anomalous magnetic moment of the electron; inspiring the relativistic theory of quantum electrodynamics; and leading to the development of the hydrogen maser.

Mixing plasmas

The ALPHA-2 experiment receives its antiprotons from the CERN Antiproton Decelerator and its positrons are produced by radioactive decay. In a typical experimental run, the team mixes cold plasmas containing about 90,000 antiprotons and 1.6 million positrons to create about 25,000 antihydrogen atoms. Most of these atoms have far too much kinetic energy to be useful so the vast majority are discarded. This leaves about 20 atoms, which are held in a superconducting magnetic trap. If the mixing process is repeated, up to 74 atoms can be accumulated for study.

In the presence of the trap’s magnetic field, the hyperfine energy levels are further split into two distinct pairs of states. One pair is “trappable” – atoms in those two states will remain in the trap. The other pair is “untrappable” – atoms in those two states will quickly be lost from the trap.

Measurements are made by applying microwave radiation to the trapped atoms. If the frequency of the microwaves matches the frequency associated with a transition from a trappable to an untrappable state, some of the atoms will become untrapped and will annihilate on the inner surface of the trap. This annihilation releases a significant amount of energy, which is captured by special detectors.

Twin peaks

The experiment involves slowly scanning the microwave frequency and measuring the number of annihilation events. The result is two peaks, with the hyperfine splitting corresponding to the energy difference between the peaks.

The team’s measured value for antihydrogen hyperfine splitting (expressed in terms of photon frequency) is 1420±0.5 MHz, which agrees with the measured value for hydrogen to four parts in 10,000.

Although the measurement provides no evidence that the physics of antihydrogen is any different to that of hydrogen, the team says that it opens the door to more precise measurements of the spectrum of antihydrogen. Writing in Nature, the team points out that future measurements of the shape of antihydrogen spectral lines could reveal new physics.

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