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Letter from Argentina: ‘an empty desk and an idle electron microscope signal the erosion of the country’s science’

I am writing from Argentina as a researcher working within the country’s national scientific system. While discussions about science funding are often framed in terms of budgets and economic indicators, the reality is experienced in laboratories, offices and research facilities where scientific knowledge is produced.

Today, many of us in Argentina are witnessing a progressive deterioration of Argentine science, both in terms of infrastructure and human capital.

I am based at the Comisión Nacional de Energía Atómica (CNEA), where uncertainty has become routine. Hundreds of employees remain on temporary contracts that can be terminated without warning. On 1 July 2026, a total of 61 colleagues lost their jobs, with armed military police officers occupying the building to contain a peaceful employee protest. Beyond the immediate human cost, these dismissals are steadily dismantling scientific capabilities that have taken decades to build.

The impact became tangible when my colleague Paula Alderete, an experienced electron microscope specialist, lost her position. Alderete, who has published two papers with me, was responsible not only for operating a highly specialized instrument, but also for maintaining it and supporting dozens of research projects.

Without Paula Alderete’s expertise, our lab’s electron microscope has become largely unusable. It is a quiet reminder that scientific infrastructure depends as much on people as on expensive equipment.
Faramarz S Gard

Without her expertise, the microscope has become largely unusable. Every morning I pass her empty desk on my way to the laboratory. It has become a quiet reminder that scientific infrastructure depends as much on people as on expensive equipment.

The deterioration extends beyond personnel. In my laboratory, an X-ray photoelectron spectroscopy (XPS) instrument worth more than $1m must sometimes be protected with plastic sheets because rainwater leaks through the roof.

Equipment designed to operate under tightly controlled environmental conditions is now exposed to circumstances that threaten its long-term reliability. Similar situations are becoming increasingly common across Argentina’s universities and research institutes as maintenance budgets shrink and infrastructure ages.

Argentina has a scientific tradition that reaches far beyond its borders. The country has produced five Nobel laureates, including three in the sciences, and has made internationally recognized contributions to nuclear technology, medicine, agriculture, astronomy and materials science. Institutions such as CNEA, CONICET (Argentina’s national research council) and the national universities have trained generations of researchers whose work has strengthened international collaborations and advanced scientific knowledge worldwide.

Scientific systems rarely collapse through a single dramatic event. They decline incrementally: one technician dismissed, one laboratory left unrepaired, one instrument taken out of service, one young scientist deciding to build a career elsewhere. These individual losses accumulate into a weakening of scientific capacity that may take decades to rebuild.

When a country loses the expertise required to operate advanced laboratories or maintain unique scientific infrastructure, the consequences extend beyond national borders.
Faramarz S Gard

This should concern more than Argentina. Modern science depends on international networks of researchers, shared facilities and long-term collaboration. When a country loses the expertise required to operate advanced laboratories or maintain unique scientific infrastructure, the consequences extend beyond national borders.

covered microscope and leaky ceiling in lab in argentina — **Damaged goods** This X-ray photoelectron spectrometer at the author’s lab has to be protected from water leaking through the ceiling. (Courtesy: Faramarz S Gard)

Knowledge is lost, collaborations weaken, and opportunities for discovery diminish.scientific infrastructure is more than buildings and instruments; it is the people whose expertise gives those resources value. Once that expertise disappears, replacing it is far more difficult than preserving it.

The empty desk of a single scientist may seem insignificant, but multiplied across laboratories and institutions, it becomes a warning of how a research system is quietly dismantled. Argentina’s experience is therefore not only a national concern but also a reminder that scientific capacity, wherever it exists, is a global resource that is remarkably difficult to rebuild once lost.

I write this letter not only to describe a difficult situation but also to call attention to the broader consequences of sustained disinvestment in science. The international scientific community should recognize that the erosion of research systems in countries such as Argentina represents a loss not only for those nations but for global science itself.

Science is built by people, sustained by institutions, and enabled by infrastructure. Today, all three are under increasing strain in Argentina.

Discovery of giant ‘exosatellite’ challenges our notion of what makes a moon

A possible “exosatellite” has been discovered 73 light years away. Bizarrely, it is roughly the size of Jupiter and orbiting a failed star called a brown dwarf, which in turn is orbiting the red dwarf star CD-35 2722.

This huge alien “moon” was found by the Very Large Telescope’s CRIRES+ spectroscopic instrument, which measured the Doppler shift in the brown dwarf’s light as the exosatellite gravitationally tugged on it. This is the same method used to discover the first known exoplanet around a Sun-like star, namely 51 Pegasi b, in 1995.

Only a handful of exosatellite candidates have been discovered thus far, with none being particularly convincing. This newly detected satellite, reported in Nature, is possibly the best of the bunch. The brown dwarf, known as CD-35 2722b, has a mass about 37 times greater than Jupiter and its exosatellite has a minimum mass of 90% that of Jupiter.

Moon, satellite or planet?

Planetary mass objects around brown dwarfs have been discovered before. Take the example of 2M1207b, which is an object up to six times more massive than Jupiter orbiting a brown dwarf, discovered in 2005 by the Very Large Telescope. Such objects have not been referred to previously as moons or satellites, so why now?

“This system is meaningfully different from 2M1207 because of the mass ratios and separations involved in CD-35 2722,” says Kevin Hoy, a PhD candidate at the European Southern Observatory and the Instituto de Estudios Astrofísicos in Chile, who led the discovery.

Whereas 2M1207b is approximately a quarter of the mass of its host brown dwarf and on a very wide orbit, possibly as long as 20,000 years, CD-35 2722b’s satellite has about 2.5% of the mass of its host brown dwarf and is on a much closer 170-day orbit.

There’s also the hierarchy of the system to consider. In the 2M1207 system, the brown dwarf doesn’t orbit anything, but in CD-35 2722 the brown dwarf is on a 5000-year-long orbit around its companion star. The candidate exosatellite therefore orbits something that orbits a star, just as a given moon in our Solar System orbits a planet that orbits a star. Since our Solar System has nothing like this brown dwarf–satellite combination, the language that we use to describe such objects is seemingly inadequate.

Mary Anne Limbach of the University of Michigan, who was not involved in this study, agrees that our nomenclature is increasingly ill-suited to the bizarre objects that we are discovering beyond our Solar System.

“Most people in the astronomical community would probably hesitate to call this an exomoon,” she tells Physics World. “But I think ‘exosatellite’ is appropriate. The field needs language for companions that do not neatly fit into the traditional categories of planets and moons, and ‘satellite’ seems to be the broader term that the field is gravitating towards.”

Forming exosatellites

Definitions are important, adds Limbach, because they allow us to distinguish between how otherwise similar objects formed.

The moons in our Solar System formed from debris discs encircling their parent planets. Material in the discs clumped together, forming cores that were then able to sweep up the remainder of the material. Astronomers refer to this as core accretion formation.

“If I had to put money on it, I would doubt that the CD-35 2722b satellite formed via core accretion for several reasons,” says Hoy. These reasons include the size of the disc required to build such a massive satellite, the speed with which it would have done so (it is only 150 million years old) and its eccentric orbit. Moons born in situ around their parent typically adopt a more circular orbit.

Instead, Hoy suspects that the brown dwarf and its satellite collapsed directly out of a gas cloud in much the same way that stars do. “That would be my best guess,” he says.

The formation mechanism makes all the difference to Limbach, who opines that, “an object can reasonably be called a moon if it formed through a process analogous to the formation of the moons around the Solar System’s planets.”

Limbach cautions that since we only know the satellite’s minimum mass, we cannot yet rule out this being a binary system of two brown dwarfs. Either way, Limbach sees the system as being close to that of a binary giant planet. Our understanding of how giant planetary bodies and low-mass brown dwarfs form tells us that binary giant planets should be rare, “but the first emerging examples hint that they may not be,” says Limbach. These include about 40 pairs of rogue binary giant planets, called Jupiter Mass Binary Objects (JuMBOs), found by the James Webb Space Telescope in the Orion Nebula’s Trapezium star cluster.

Tip of the iceberg

Another unanswered question is how far down does CD-35 2722’s hierarchy go? Could the exosatellite have moons of its own?

“I think it’s definitely possible,” says Hoy, so long as they are on tight orbits so that gravitational tides cannot destabilize them. “Unfortunately such an object is likely impossible to detect with our current methods.”

However, our current methods could soon learn that CD-35 2722 is just the tip of the iceberg.

Moon-forming disc is spotted around a giant exoplanet

“Looking at directly imaged planets and brown dwarfs is the most likely way to yield more exosatellites,” says Hoy, while also citing astrometry (looking for deviations in the motion of a star through space) and microlensing (where the gravity of an otherwise unseen exosatellite creates a temporary gravitational lens) as key techniques that could bring dividends.

Meanwhile, it is hoped that the European Space Agency’s PLATO mission, which will discover exoplanets via transits, will detect significantly large terrestrial moons once the mission launches at the beginning of 2027. All in all, we could be on the cusp of a new era of exomoon and exosatellite discovery.

The science of being ‘cultured’: a slide puzzle

To play, click or drag one or more tiles to move them into the empty space. Repeat until you have reconstructed the image.

Image courtesy: iStock/vasantytf; iStock/extravagantni

Fancy some more? Check out our puzzles page.

John Bell and the most obscure journal in physics

As I was strolling through Belfast’s Titanic Quarter last summer, I discovered with delight a road called Bell’s Theorem Crescent. It’s named in honour of the Belfast-born physicist John Bell, best known for his eponymous theorem. Despite not being as embedded in popular culture as Schrödinger’s cat, his theorem will certainly ring a bell (forgive the pun) with most physicists.

The story goes back to 1935 when Albert Einstein, Boris Podolski and Nathan Rosen (EPR) came up with their now-famous thought experiment, which was designed to show that quantum mechanics was, as a description of nature, incomplete. In the EPR scenario, non-local influences can affect the measurement outcomes performed on spatially separated particles.

Given how odd that seemed, some physicists invoked what are known as “hidden variables” to get rid of these non-local correlations and restore local realism. It was in 1964, while working at the CERN particle-physics lab, that Bell showed that no local hidden-variable theory can be compatible with the predictions of quantum mechanics.

This result – Bell’s theorem – is something I was familiar with but I had paid little attention to where it had originally appeared. As I discovered, it was published in a paper called “On the Einstein Podolsky Rosen paradox” in the journal Physics (3 195) in 1964. Also known as Physics Physique Физика, this little-known publication existed only from 1964 to 1968. In fact, Bell’s theorem is the most important result published in it.

The journal was set up by two physicists at Bell Laboratories in the US – Bernd Matthias and future Nobel laureate Philip Anderson. According to A Mind Over Matter – Andrew Zangwill’s 2021 biography of Anderson – they were not too happy with conventional physics journals. “The referees,” Anderson said, “often did a bad job, the editors took too long to make decisions, and too much wrong physics got published.”

Those are complaints you’ll still hear in coffee breaks at most physics conferences today, and they prompted Matthias to contact the media magnate Robert Maxwell, who’d founded Oxford-based publishing house Pergamon Press. Maxwell had figured out that scientific publishing could be a very lucrative business so he helped the two physicists to set up the journal.

A publishing experiment

In their first editorial, Anderson and Matthias called Physics an “experimental journal”, which they hoped would solve the problem of there being “far more good physics written than any physicist can read”. Their solution was to pick only those papers worth the attention of all physicists, which the editors did by reviewing – then accepting or rejecting – every submission themselves. They even paid authors 10 cents a word if their paper appeared in print.

Anderson and Matthias admitted that many physicists had already written to them, criticizing their proposed selection model. They’d been told that their “judgements will be fallible”, that they might be “overimpressed by showiness”, and that they’d end up rejecting excellent work. In response, the pair promised to try their best, accepting they would make mistakes and that their “criteria will be, not better, but different”.

The journal’s criteria clearly succeeded, in that Anderson and Matthias identified the merits of Bell’s paper, which was far from mainstream

These criteria clearly succeeded, in that they identified the merits of Bell’s paper, which was far from mainstream. Keen to find out more about the events surrounding its publication, I contacted Zangwill, who had interviewed Anderson several times for his book. Zangwill shared the following quote, published here for the first time.

“One day,” Anderson recalled, “a paper came in from a guy neither of us had heard of – John Bell. It was about hidden variables in quantum mechanics. Bernd had no clue, but I accepted it with the hope that its publication would spell the death of Bohmian trajectory quantum mechanics. It’s a very famous paper today.”

In 1967 the quantum physicist John Clauser found Bell’s paper after stumbling upon Physics Physique Физика, attracted by its unusual title. Clauser, who shared the 2022 Nobel Prize in Physics, carried out the first Bell test in 1972 with Stuart Friedmann. Their work triggered a long series of experiments that would deepen our understanding of quantum mechanics and catalyse the development of quantum technologies.

Over its short life, Physics did publish work from other notable physicists including Murray Gell-Mann, Leonard Susskind and Leo Kadanoff. In fact, the journal was ahead of its time, with the model of in-house editorial selection for broad interest returning in the 2000s with the Nature series of journals. The inclusive, multi-language title was also well ahead of its day.

Sadly, Physics Physique Физика was discontinued in 1968 after just three volumes

Sadly, Physics Physique Физика was discontinued in 1968 after just three volumes. According to what Anderson told Zangwill, it stopped “not because it lacked submissions, but because they had promised contributors rapid publication and Maxwell kept increasing the time between the appearances of successive issues”. Maxwell’s aggressive pursuit of profit might also have played a role.

The journal has since been archived by the American Physical Society and is freely accessible online. One can only wonder what might have happened if Anderson and Matthias had picked a different name for their journal.

The physics of protein condensates

Intrinsically disordered proteins (IDPs) do not form stable 3D structures. Instead, they remain flexible, adopt many conformations, and can interact with multiple molecules. Although proteins were once thought to require a fixed structure to function, many IDPs play essential cellular roles. Some IDPs can assemble into biomolecular condensates, membrane-less compartments that help organise processes such as gene expression and stress responses.

Many IDPs contain prion-like low complexity domains (PLCDs), which have defined sequence features known as molecular grammas. These IDPs are multivalent and can form hierarchies of interactions with one another. These interactions promote clustering and, under the right conditions, phase separation into a protein-rich condensate and a surrounding dilute phase. Dysregulation of condensates has been linked to disease.

In this study, researchers used computer simulations to investigate the PLCD known as A1-LCD. Their aims were to accurately identify the critical point where phase separation ceases, map the full phase diagram, and assess methods used to estimate the theta temperature (Tθ), a measure related to solvent quality and protein interactions.

The simulations revealed three distinct phase-separation regimes: a dilute phase containing mostly isolated proteins, an intermediate regime where clusters form before large condensates appear, and a regime near the critical point characterised by system-spanning networks. The study also showed that condensates behave as percolated networks of interconnected proteins. Importantly, the authors found that commonly used methods for estimating theta temperature may be inaccurate for these systems.

Overall, this work provides new insights into the phase behaviour of condensate-forming proteins and highlights the need for more reliable approaches to assessing solvent quality. These findings could improve future studies of biomolecular condensates and their roles in health and disease.

“Comparative assessments of driving forces for phase separation requires knowledge of IDP-specific critical points. Our application of rigorous finite size scaling methods pioneered by Kurt Binder helped us delineate the critical and mean field regimes and demonstrate how the critical point can be converged upon for realistic approximations of IDPs. This revealed several surprises regarding the complex nature of the coexisting dilute phase. Additionally, we found that calculation of the two-body interaction coefficient provides a computationally tractable approach to compute comparative, sequence-encoded driving forces for phase separation of IDPs. This is directly relevant to inferring how changes to molecular grammars influence phase behaviors driven by homotypic associations.” – Rohit V. Pappu, Washington University in St. Louis

Read the full article

Distinguishing near- versus off-critical phase behaviors of intrinsically disordered proteins

Gaurav Mitra et al 2026 Rep. Prog. Phys. 89 068101

Do you want to learn more about this topic?

Biomolecular dynamics: order–disorder transitions and energy landscapes by Paul C Whitford, Karissa Y Sanbonmatsu and José N Onuchic (2012)

Nonlinear photoexcitation in Mott Insulators

According to band theory, materials with partially filled energy bands and unpaired electrons should conduct electricity, but in Mott insulators this rule is broken. In these materials, the repulsion between electrons is so strong that they cannot move freely and become localized. When sufficient energy is supplied (for example by light), electrons can form a doublon (two electrons on one site) and a hole (an empty site). These excitations can move, enabling electrical conductivity.

A key question for Mott insulators is how these charge carriers are created and what controls their production. Traditionally, two regimes were known: multiphoton absorption, where several photons combine their energy, and tunnelling, where a strong electric field drives electrons across the gap.

In this work, the authors show that there are actually four regimes: multiphoton, tunnelling, a cooperative regime where the two processes work together, and an incoherent regime where weak fields and scattering dominate. They also show that the energy gap (the cost to create a doubloon-hole pair) is not fixed, but changes during the process because the generated carriers modify the system. This creates a feedback loop, making the dynamics nonlinear and time-dependent. As a result, carrier production can either slow down or suddenly speed up, even making the system more efficient without changing the driving field.

The behaviour depends on field strength, frequency, dissipation, and time, and each mechanism can be identified by its distinct momentum pattern. By tuning laser parameters, the system’s properties can be controlled in real time. Overall, this work shows that light can be used to dynamically reshape and control strongly interacting materials, opening possibilities for ultrafast, light-driven technologies.

Read the full article

Subgap pumping of antiferromagnetic Mott insulators: photoexcitation mechanisms and applications

Radu Andrei et al 2026 Rep. Prog. Phys. 89 068004

Do you want to learn more about this topic?

PLP-Logo-2.png, find out more. Quantum frustration in organic Mott insulators: from spin liquids to unconventional superconductors by B J Powell and Ross H McKenzie (2011)

Privacy risks from medical AI are greater than previously thought

Schematic of a membership inference attack — **Membership inference attack** An untrusted user aims to infer whether a specific target record was part of the training dataset, by observing the predictions of a model. The attack is successful if they can reliably distinguish between models A and B, which are identical except for the inclusion or exclusion of the target record in the respective training dataset. (Courtesy: CC BY 4.0/*Nature* 10.1038/s41586-026-10688-0)

A new study has revealed that sensitive health information about individual patients can be extracted from medical artificial intelligence (AI) models more effectively than previous research had indicated.

Diagnostic AI models are used to determine whether some given health data belong to a specific class – for example if an X-ray image shows evidence of pneumonia – and offer huge promise for improving patient outcomes. Earlier studies showed that membership inference attacks (MIAs), which determine whether a particular person’s data was used to train an AI model, yielded results no better than random chance. But these previous studies only evaluated the average risk across all patients in a training dataset.

By contrast, in this latest work doctoral student Moritz Knolle and his supervisor Daniel Rückert at the Technical University of Munich (TUM), together with collaborators at Imperial College London and Georg Kaissis from the Hasso Plattner Institute (HPI), examined the privacy risk for an individual patient. “Privacy that only works on average has little meaning. So I asked myself: would I contribute my data to train a medical AI model?” says Knolle.

Daniel Rückert from TUM — **Investigating the risks** A team led by Daniel Rückert (pictured) at TUM and Georg Kaissis from HPI found that medical AI is more vulnerable to certain attacks than previously thought. (Courtesy: Juli Eberle/TUM)

As detailed in their recent Nature paper, the researchers attacked AI models based on seven different types of real-life medical datasets, including one comprising 21,799 electrocardiograms and another of 377,110 chest radiographs.

“If a model sees a specific data point during training, it usually becomes more confident at predicting it. So in these MIA attacks I compare the predictive probability number for this data point outputted by the medical AI model with the predictive probability number obtained from my model which has not seen that data point,” explains Knolle, adding that the attack is essentially a statistical test to distinguish between the two models.

Their results revealed that the privacy risk for an individual was far greater than the average risk. The team also found that privacy risk is not equally distributed among subgroups.

“We found that patients from minority groups that are under-represented in the training dataset tend to be over-represented among the 99 percentile of extreme [privacy] risk,” Knolle tells Physics World, warning that as medical AI models become larger and more sophisticated the privacy risk is amplified because their deep analysis creates the small changes in predictive probability that MIAs are good at finding.

While an MIA that reveals someone is a UK citizen poses little security risk, discovering that an individual has received a specific type of cancer treatment reveals personal information that could, for instance, adversely affect their medical insurance premiums. “The more specific the training cohort is, the larger the privacy risk,” states Knolle, crediting his medical doctor parents with inspiring his desire to improve healthcare AI.

Countermeasures include differential privacy (DP), in which a small amount of Gaussian random white noise is added in alongside the data during training, thereby reducing the effectiveness of MIAs while maintaining the model’s diagnostic accuracy. “This gives a mathematically provable upper bound for how much privacy risk any individual in this dataset could face, by limiting the information content that flows to the AI model,” explains Knolle.

He notes that, unfortunately, such DP tools have not been widely adopted by hospitals or clinics. This, he fears, could undermine patients’ confidence in sharing their data, and thereby not only reduce AI’s ability to help combat rare diseases, but also compound AI discrimination that occurs when there is too little data from minority groups included in training datasets.

“So we are hoping to inspire the medical AI community to do risk assessments before deploying AI models, and use verifiable strategies such as DP or limiting access to the AI model, so that as an individual you have a statistical guarantee that no harm would come to you by being part of a dataset,” concludes Knolle, who now plans to investigate the privacy risks posed by generative AI models for healthcare.

Environmental Research: Climate, fireside chat

Want to take part in this webinar?

Environmental Research: Climate was launched in 2022, with the aim of uniting multidisciplinary communities. With a scope that is intentionally broad, the mission of the journal is to publish innovative research examining the causes, consequences, and solutions of climate variability and change. Since our launch, we have published more than 270 articles covering physical and biogeochemical processes that shape Earth’s climate across spatial and temporal scales; the human and ecological dimensions that shape climate-related risks and impacts; and the design, analysis and evaluation of climate mitigation, adaptation, and risk-management strategies and solutions. This webinar will explore the current state of climate research, including changes in the field over the last five years since the launch of the journal, and direct us toward the future.

Want to take part in this webinar?

Left to right: Noah Diffenbaugh, Katharine Mach, Andrew Pershing, Inês Azevedo

Moderator: Noah Diffenbaugh, Stanford University
Noah Diffenbaugh is the William Wrigley Professor and Kimmelman Family Senior Fellow in Stanford’s Doerr School of Sustainability, and the Olivier Nomellini Family University Fellow in Undergraduate Education. His research is focused on understanding what aspects of the climate system most directly and acutely impact people and ecosystems. Noah has served as a Lead Author for the Intergovernmental Panel on Climate Change (IPCC), and as editor-in-chief of the peer-review journals Geophysical Research Letters and Environmental Research: Climate. He has provided testimony and scientific expertise to federal, state and local officials. Noah is an elected Fellow of the American Geophysical Union (AGU), a recipient of the James R. Holton Award and William Kaula Award from the AGU, and has been recognized as a Kavli Fellow by the U.S. National Academy of Sciences.

Katharine Mach, University of Miami
Katharine Mach is professor and chair of the Department of Environmental Science and Policy at the University of Miami Rosenstiel School of Marine, Atmospheric, & Earth Science. During spring 2025, she was the Coleman P. Burke Distinguished Visiting Professor at the Yale School of Environment. Her research assesses climate-related risks and response options to address increased flooding, extreme heat, wildfire and other hazards. Through innovative approaches to integrating evidence, she informs effective adaptations to the risks.

Katharine was the 2020 recipient of the Piers Sellers Prize for world-leading contribution to solution-focused climate research. She has served as a chapter author or lead in the Fourth through Sixth US National Climate Assessments and the IPCC Sixth Assessment Report and as a member of the National Academies Climate Security Roundtable. She serves as co-editor-in-chief for Climate Risk Management, an editorial board member for Oxford Open Climate Change and Environmental Research: Climate, and an advisory committee member for the Aspen Global Change Institute. Across all of her research projects, she engages in relevant policy processes and explores and discusses climate risk and adaptation with the media, the private sector, nongovernmental organizations and communities.

Andrew Pershing, Climate Central
As chief programme officer, Andrew Pershing, PhD, leads Climate Central’s climate science activity. His role includes bridging primary research and media analysis to amplify critical work on climate change and climate impacts and make it accessible to audiences around the world. As the director of attribution science and climate fingerprinting, Andrew is developing tools like the Climate Shift Index to quantify how climate change has increased the likelihood or severity of conditions in the atmosphere and ocean. He works closely with communications experts at Climate Central and our partners to help the media and others to incorporate this information into their content.

Andrew has led interdisciplinary research teams to study the impact of global warming on marine ecosystems in the northwest Atlantic. More recently, his work has focused on how climate trends interact with decisions that people make and on how marine ecosystems store and process carbon. As a communicator, Andrew has deep experience working with journalists to present climate science on air and in print.

Inês Azevedo, Stanford University
Inês M Lima Azevedo is a professor in the Energy Science & Engineering department at Stanford University. She is a senior fellow at both Stanford Woods Institute for the Environment and for Precourt Institute for Energy. She has a BSc in environmental engineering (2004) and a MSc in engineering policy and management of technology from IST-Portugal, and a PhD in engineering and public policy from Carnegie Mellon University (2009). Inês is passionate about solving problems that include environmental, technical, economic and policy issues, where traditional engineering approaches play an important role but cannot provide a complete answer. In particular, she is interested in assessing how energy systems are likely to evolve, which requires comprehensive knowledge of the technologies that can address future energy needs and the decision-making process followed by various agents in the economy.

About this journal

Environmental Research: Climate explores the causes, consequences, and solutions of climate variability and change, by uniting research communities across the entire spectrum of the climate system.

Editor-in-chief: Noah Diffenbaugh Stanford University, USA

Scientists discover sugar in interstellar space

Sugars are a vital ingredient in the recipe for life, responsible for a range of biological processes and a key component of nucleic acids such as DNA and RNA. The question of how these essential biomolecules were produced on primitive Earth is a pressing concern for origin-of-life researchers, with laboratory experiments suggesting that primordial conditions would not yield sufficient quantities.

In a study led by Izaskun Jiménez-Serra at the Centro de Astrobiología (CAB, CSIC-INTA) in Spain, researchers have observed a four-carbon sugar, erythrulose, in the interstellar medium for the first time. Such sugar could have contributed to the resources available for early biological processes, providing insight into how life began on Earth.

Sugars in space

Based on studies of asteroid samples, researchers suggest that key building blocks for life may have had an extraterrestrial origin. Previous analysis of samples from the asteroid Bennu has demonstrated the presence of the sugar glucose, a primary energy source for biological processes, and ribose, a sugar that contributes to the development of nucleic acids.

The idea is that meteorites and comets containing these important chemical components impacted Earth and contributed to the resources available to develop life. This latest research looks backwards in this process to question whether these molecules may have formed in the clouds of dust and gas that parent these astronomical bodies.

Detailed in Nature Astronomy, this first observation of sugar in the interstellar medium suggests that the ingredients for life may indeed form in dust clouds as previously proposed.

Detecting erythrulose

To detect these molecules, Jiménez-Serra and colleagues used the Yebes 40 m and IRAM 30 m telescopes in Spain. Ultrasensitive, broadband spectral surveys allowed them to identify the signature of erythrulose inside G+0.693−0.027, a cloud of gas close to the centre of the Milky Way.

The team had to overcome various challenges, including the spectral signatures of different molecules overlapping and blending into one another. To ensure the validity of their observations, they identified over 180 molecular species to better understand any possible interference with the emission of erythrulose. This extensive characterization allowed the researchers to obtain very high levels of confidence in their observations, they say.

The team also analysed how the erythrulose may have been formed in the extreme low temperatures and vacuum conditions of interstellar space. The abundance of erythrulose is eight times that of three-carbon sugars which are currently undetected by these incredibly sensitive observations. This led the team to model the formation of erythrulose from simpler and more readily available two-carbon aldehydes and alcohols – a process that occurs on the surface of grains of dust in space, with the potential to then contribute to chemical systems on Earth.

Extraterrestrial building blocks

On Earth, erythrulose is found in fruits such as melons and raspberries. In aqueous environments, such as bodies of water on Earth, erythrulose easily changes its configuration into the sugar threose. Similar to ribose in RNA, threose appears in threose nucleic acid (TNA). One of the simplest nucleic acids, TNA may be one of the first involved in the early development of life.

According to Jiménez-Serra: “The discovery of erythrulose in the interstellar medium opens up the possibility for these key organic compounds to form in other molecular clouds in the Galaxy where stars and planets are forming”.

The team’s future plans include searching for larger sugars such as the five-carbon ribose found in RNA. “By combining astronomical observations with laboratory experiments and theoretical calculations, we will explore the chemistry of these sugars and of their related compounds, which could have played a key role in the origin of life,” shared Jiménez-Serra.

The work is being completed as part of the ERC consolidator grant OPENS. This highly interdisciplinary project draws from a range of research methods and scientific fields to approach the question of how life begun on earth. By continuing this research, the team hopes to learn more about the very earliest stage of our journey on this planet.

Structured light could deliver a new method for diagnosing eye disease

By controlling a type of polarized light widely used in quantum optics, researchers have transformed subtle optical patterns in our peripheral vision into vibrant, easily perceptible shapes. Led by Dusan Sarenac at the University of Waterloo, Canada, the team showed for the first time that the “Boehm’s brushes” perceived by participants can be altered by adjusting the topology of spin-orbit coupled light. Their results, reported in Proceedings of the National Academy of Sciences, could lead to promising new techniques for checking our eye health.

For the most part, human eyes are incapable of detecting polarization in visible light. But in some rare cases, structures inside the eye itself can scatter light in different ways depending on its polarization, creating subtle yet perceivable “entoptic” patterns. Perhaps the best-known examples of these are “Haidinger’s brushes”: hourglass-shaped patterns that can form in our central vision, but only when viewing linearly polarized light at blue wavelengths.

In 1940, Swiss biophysicist Gundo Boehm discovered another example: a two-lobed, bowtie-shaped entoptic pattern that forms when viewing linearly polarized light in the peripheral vision as it scatters from subcellular structures in the inner retina. Unlike Haidinger’s brushes, this lesser-known effect is driven by angular variations in scattering strength relative to the polarization direction.

But as Sarenac explains, these ethereal shapes are more than just a curiosity. “Because retinal disease may alter a person’s ability to perceive the pattern, researchers have long considered whether Boehm’s brushes could serve as a biomarker of retinal health,” he says. “However, their weak visibility has limited practical use.”

Whereas previous studies simply asked participants to passively observe the effect, Sarenac’s team considered what would happen if the light’s polarization was constantly varied. To explore this possibility, the researchers created a beam of spin-orbit coupled light, in which polarization is linked to the light’s orbital angular momentum – a property describing how the wavefront twists as the beam travels – so that the polarization direction rotates steadily across the beam.

In quantum optics, these structured waveforms are already being widely explored for their possibilities in imaging, communication and information processing. But for the first time, Sarenac’s team considered how our eyes could actually perceive this light. “We engineered the spatial polarization of the light to match the symmetry of the retinal scattering response,” Sarenac describes. “This allowed many weak local contributions to reinforce one another.”

The researchers then projected this structured light through a ring-shaped aperture, targeting specific regions in the periphery of participants’ retinas, which could also be adjusted to target varying distances from the centre of vision. Using an automated test, they measured how much contrast participants needed to reliably distinguish a Boehm’s brush from the background at these varying distances.

Based on the subject’s responses, Sarenac’s team determined that the use of spin-orbit coupled light not only made Boehm’s brushes appear far more vivid to the participants, it also transformed the bowtie shape into a multi-lobed pattern, with the number of lobes varying depending on the topology of the light’s twisting polarization.

“Across 11 participants, detection thresholds improved exponentially away from the centre of vision, and the pattern became robustly visible at approximately one degree of retinal angular distance,” Sarenac describes. These results reveal a fascinating link between human vision and quantum mechanics, which the team hope could be harnessed in practical healthcare. With further studies involving patients with retinal disease, they now envisage eye tests where retinal conditions could be diagnosed in people who can’t clearly perceive vibrant, multi-lobed Boehm’s brushes in their peripheral vision.

“In the longer term, these patterns may provide a non-invasive functional probe of retinal integrity because their shape and visibility can be measured across different retinal locations,” Sarenac says.

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